PMID- 35395486 OWN - NLM STAT- MEDLINE DCOM- 20220517 LR - 20230616 IS - 1872-8421 (Electronic) IS - 0165-5728 (Print) IS - 0165-5728 (Linking) VI - 367 DP - 2022 Jun 15 TI - Retinal pathology in spontaneous opticospinal experimental autoimmune encephalitis mice. PG - 577859 LID - S0165-5728(22)00054-6 [pii] LID - 10.1016/j.jneuroim.2022.577859 [doi] AB - Retinal ganglion cells (RGC) are lost as a sequela of optic nerve inflammation in myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD), but the mechanisms of injury remain incompletely understood and there remains a need to characterize the murine model of MOGAD. Several studies have shown that RGC loss occurs in association with optic neuritis in MOG(35-55) experimental autoimmune encephalomyelitis (EAE), but retinal pathology has not been studied in the double transgenic opticospinal EAE (OSE) model, in which animals develop spontaneous disease associated with MOG(35-55) peptide specific T cells and B cells producing MOG-specific antibodies. Herein, we show that at 8-weeks OSE mice develop optic nerve inflammation, reactive astrogliosis, and RGC loss. By 10-weeks of age, affected mice have a 50% reduction in RGCs as compared to age matched wild type mice without EAE. The retinal pathology that ensues from spontaneous optic neuritis in OSE mice mirrors that seen following human optic neuritis and may be a useful model for screening neuroprotective compounds for MOGAD and other diseases with optic neuritis. CI - Copyright (c) 2022 Elsevier B.V. All rights reserved. FAU - Jin, Jing AU - Jin J AD - Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: jjin11@jhmi.edu. FAU - Shneyderman, Mark AU - Shneyderman M AD - Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: mshneyd1@alumni.jh.edu. FAU - Smith, Matthew D AU - Smith MD AD - Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: matthewsmith@jhu.edu. FAU - Gharagozloo, Marjan AU - Gharagozloo M AD - Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: mgharag1@jhu.edu. FAU - Sotirchos, Elias S AU - Sotirchos ES AD - Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: ess@jhmi.edu. FAU - Calabresi, Peter A AU - Calabresi PA AD - Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, United States of America; Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: pcalabr1@jhmi.edu. LA - eng GR - R01 NS041435/NS/NINDS NIH HHS/United States PT - Journal Article DEP - 20220331 PL - Netherlands TA - J Neuroimmunol JT - Journal of neuroimmunology JID - 8109498 RN - 0 (Myelin-Oligodendrocyte Glycoprotein) RN - Hashimoto's encephalitis SB - IM MH - Animals MH - *Encephalomyelitis, Autoimmune, Experimental/complications MH - Hashimoto Disease MH - Inflammation/pathology MH - Mice MH - Mice, Inbred C57BL MH - Myelin-Oligodendrocyte Glycoprotein MH - *Optic Neuritis/complications MH - *Retina/pathology PMC - PMC9106884 MID - NIHMS1795999 OTO - NOTNLM OT - Astrocytes OT - EAE OT - Optic neuritis OT - Retinal ganglion cells EDAT- 2022/04/09 06:00 MHDA- 2022/05/18 06:00 PMCR- 2023/06/15 CRDT- 2022/04/08 20:11 PHST- 2022/01/18 00:00 [received] PHST- 2022/03/20 00:00 [revised] PHST- 2022/03/28 00:00 [accepted] PHST- 2022/04/09 06:00 [pubmed] PHST- 2022/05/18 06:00 [medline] PHST- 2022/04/08 20:11 [entrez] PHST- 2023/06/15 00:00 [pmc-release] AID - S0165-5728(22)00054-6 [pii] AID - 10.1016/j.jneuroim.2022.577859 [doi] PST - ppublish SO - J Neuroimmunol. 2022 Jun 15;367:577859. doi: 10.1016/j.jneuroim.2022.577859. Epub 2022 Mar 31.