PMID- 35395826
OWN - NLM
STAT- MEDLINE
DCOM- 20220412
LR  - 20230110
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 13
IP  - 1
DP  - 2022 Apr 8
TI  - Electrocorticographic evidence of a common neurocognitive sequence for 
      mentalizing about the self and others.
PG  - 1919
LID - 10.1038/s41467-022-29510-2 [doi]
LID - 1919
AB  - Neuroimaging studies of mentalizing (i.e., theory of mind) consistently implicate 
      the default mode network (DMN). Nevertheless, the social cognitive functions of 
      individual DMN regions remain unclear, perhaps due to limited spatiotemporal 
      resolution in neuroimaging. Here we use electrocorticography (ECoG) to directly 
      record neuronal population activity while 16 human participants judge the 
      psychological traits of themselves and others. Self- and other-mentalizing 
      recruit near-identical cortical sites in a common spatiotemporal sequence. 
      Activations begin in the visual cortex, followed by temporoparietal DMN regions, 
      then finally in medial prefrontal regions. Moreover, regions with later 
      activations exhibit stronger functional specificity for mentalizing, stronger 
      associations with behavioral responses, and stronger self/other differentiation. 
      Specifically, other-mentalizing evokes slower and longer activations than 
      self-mentalizing across successive DMN regions, implying lengthier processing at 
      higher levels of representation. Our results suggest a common neurocognitive 
      pathway for self- and other-mentalizing that follows a complex spatiotemporal 
      gradient of functional specialization across DMN and beyond.
CI  - (c) 2022. The Author(s).
FAU - Tan, Kevin M
AU  - Tan KM
AUID- ORCID: 0000-0003-4299-996X
AD  - Social Cognitive Neuroscience Laboratory, Department of Psychology, University of 
      California, Los Angeles, CA, USA. kevmtan@ucla.edu.
FAU - Daitch, Amy L
AU  - Daitch AL
AD  - Laboratory of Behavioral and Cognitive Neuroscience, Department of Neurology and 
      Neurological Sciences, Stanford University, Stanford, CA, USA.
FAU - Pinheiro-Chagas, Pedro
AU  - Pinheiro-Chagas P
AD  - Laboratory of Behavioral and Cognitive Neuroscience, Department of Neurology and 
      Neurological Sciences, Stanford University, Stanford, CA, USA.
FAU - Fox, Kieran C R
AU  - Fox KCR
AUID- ORCID: 0000-0002-6923-4580
AD  - Laboratory of Behavioral and Cognitive Neuroscience, Department of Neurology and 
      Neurological Sciences, Stanford University, Stanford, CA, USA.
AD  - School of Medicine, Stanford University, Stanford, CA, USA.
FAU - Parvizi, Josef
AU  - Parvizi J
AUID- ORCID: 0000-0001-8520-7948
AD  - Laboratory of Behavioral and Cognitive Neuroscience, Department of Neurology and 
      Neurological Sciences, Stanford University, Stanford, CA, USA.
AD  - School of Medicine, Stanford University, Stanford, CA, USA.
FAU - Lieberman, Matthew D
AU  - Lieberman MD
AUID- ORCID: 0000-0002-4447-7359
AD  - Social Cognitive Neuroscience Laboratory, Department of Psychology, University of 
      California, Los Angeles, CA, USA.
LA  - eng
GR  - R01 MH109954/MH/NIMH NIH HHS/United States
GR  - F32 HD087028/HD/NICHD NIH HHS/United States
GR  - R01 NS078396/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20220408
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
SB  - IM
CIN - Trends Cogn Sci. 2022 Nov;26(11):906-908. PMID: 36114127
MH  - Brain/physiology
MH  - Brain Mapping
MH  - Cognition/physiology
MH  - Electrocorticography
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *Mentalization
MH  - *Theory of Mind/physiology
PMC - PMC8993891
COIS- All authors declare no conflicts of interest.
EDAT- 2022/04/10 06:00
MHDA- 2022/04/13 06:00
PMCR- 2022/04/08
CRDT- 2022/04/09 05:10
PHST- 2021/02/19 00:00 [received]
PHST- 2022/03/11 00:00 [accepted]
PHST- 2022/04/09 05:10 [entrez]
PHST- 2022/04/10 06:00 [pubmed]
PHST- 2022/04/13 06:00 [medline]
PHST- 2022/04/08 00:00 [pmc-release]
AID - 10.1038/s41467-022-29510-2 [pii]
AID - 29510 [pii]
AID - 10.1038/s41467-022-29510-2 [doi]
PST - epublish
SO  - Nat Commun. 2022 Apr 8;13(1):1919. doi: 10.1038/s41467-022-29510-2.