PMID- 35395835
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220411
IS  - 2162-3619 (Print)
IS  - 2162-3619 (Electronic)
IS  - 2162-3619 (Linking)
VI  - 11
IP  - 1
DP  - 2022 Apr 8
TI  - The clinical characteristics and prognosis in adult Ph negative acute 
      lymphoblastic leukemia with TP53 aberrations.
PG  - 22
LID - 10.1186/s40164-022-00274-1 [doi]
LID - 22
AB  - Very few reports elucidate the prognosis of patients with TP53 aberrations using 
      both measurable residual disease (MRD) and the status of having undergone 
      allogeneic hematopoietic stem cell transplantation (allo-SCT). In this study, 
      aberrations of TP53 were analyzed using next-generation sequencing (NGS) and 
      fluorescence in situ hybridization (FISH) in patients with Philadelphia 
      chromosome-negative (Ph(-)) ALL enrolled in a prospective single-arm clinical 
      trial at our leukemia center. We analyzed the survival of the patients grouped 
      according to the MRD level at the third month and whether or not received 
      allo-SCT. We found that allo-SCT could improve the OS in patients with TP53 
      aberrations; Patients having negative MRD at the third month still showed worse 
      3-year OS and 3-year DFS without undergoing allo-SCT, which is different from 
      previous studies, moreover, the prognostic significance of TP53 deletions was as 
      important as TP53 mutations, the importance of screening both TP53 deletions and 
      mutations in adult Ph(-) ALL at diagnosis should be emphasized.
CI  - (c) 2022. The Author(s).
FAU - Fang, Qiuyun
AU  - Fang Q
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of 
      Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Tianjin, 300020, China.
FAU - Gong, Xiaoyuan
AU  - Gong X
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of 
      Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Tianjin, 300020, China.
FAU - Liu, Kaiqi
AU  - Liu K
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of 
      Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Tianjin, 300020, China.
FAU - Jia, Yujiao
AU  - Jia Y
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of 
      Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Tianjin, 300020, China.
FAU - Song, Yang
AU  - Song Y
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of 
      Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Tianjin, 300020, China.
FAU - Zhang, Guangji
AU  - Zhang G
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of 
      Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Tianjin, 300020, China.
FAU - Li, Yan
AU  - Li Y
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of 
      Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Tianjin, 300020, China.
FAU - Hao, Qishan
AU  - Hao Q
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of 
      Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Tianjin, 300020, China.
FAU - Ma, Yueshen
AU  - Ma Y
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of 
      Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Tianjin, 300020, China.
FAU - Wei, Shuning
AU  - Wei S
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of 
      Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Tianjin, 300020, China.
FAU - Liu, Bingcheng
AU  - Liu B
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of 
      Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Tianjin, 300020, China.
FAU - Wang, Ying
AU  - Wang Y
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of 
      Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Tianjin, 300020, China.
FAU - Wei, Hui
AU  - Wei H
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of 
      Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Tianjin, 300020, China.
FAU - Wang, Jianxiang
AU  - Wang J
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of 
      Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Tianjin, 300020, China. wangjx@ihcams.ac.cn.
FAU - Mi, Yingchang
AU  - Mi Y
AUID- ORCID: 0000-0002-2306-4184
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of 
      Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & 
      Peking Union Medical College, Tianjin, 300020, China. ychmi@ihcams.ac.cn.
LA  - eng
GR  - 332021059/Basic Scientific Research Project of National Universities/
GR  - 20JCZDJC00120/Tianjin Municipal Science and Technology Commission Grant/
PT  - Letter
DEP - 20220408
PL  - England
TA  - Exp Hematol Oncol
JT  - Experimental hematology & oncology
JID - 101590676
PMC - PMC8991885
OTO - NOTNLM
OT  - Clinical characteristics
OT  - Ph negative acute lymphoblastic leukemia
OT  - Prognosis
OT  - TP53 aberrations
COIS- The authors declare no direct competing financial interests.
EDAT- 2022/04/10 06:00
MHDA- 2022/04/10 06:01
PMCR- 2022/04/08
CRDT- 2022/04/09 05:10
PHST- 2022/01/27 00:00 [received]
PHST- 2022/03/25 00:00 [accepted]
PHST- 2022/04/09 05:10 [entrez]
PHST- 2022/04/10 06:00 [pubmed]
PHST- 2022/04/10 06:01 [medline]
PHST- 2022/04/08 00:00 [pmc-release]
AID - 10.1186/s40164-022-00274-1 [pii]
AID - 274 [pii]
AID - 10.1186/s40164-022-00274-1 [doi]
PST - epublish
SO  - Exp Hematol Oncol. 2022 Apr 8;11(1):22. doi: 10.1186/s40164-022-00274-1.