PMID- 35397265
OWN - NLM
STAT- MEDLINE
DCOM- 20220503
LR  - 20220503
IS  - 1873-7072 (Electronic)
IS  - 0308-8146 (Linking)
VI  - 387
DP  - 2022 Sep 1
TI  - Multi-class, multi-residue determination of 132 veterinary drugs in milk by 
      magnetic solid-phase extraction based on magnetic hypercrosslinked polystyrene 
      prior to their determination by high-performance liquid chromatography-tandem 
      mass spectrometry.
PG  - 132866
LID - S0308-8146(22)00828-7 [pii]
LID - 10.1016/j.foodchem.2022.132866 [doi]
AB  - A quantitative multi-class multi-residue analytical method was developed for the 
      determination of veterinary drugs in milk by high-performance liquid 
      chromatography - tandem mass spectrometry (HPLC-MS/MS). A total of 132 veterinary 
      drugs investigated belonged to almost 15 classes including sulfonamides, 
      beta-lactams, tetracyclines, quinolones, macrolides, nitrofurans, nitroimidazoles, 
      phenicols, lincosamides, pleuromutilins, macrocyclic lactones, quinoxaline 
      antibiotics, benzimidazoles, anthelmintics, coccidiostats and some others. A 
      magnetic solid-phase extraction procedure was developed using magnetic 
      hypercrosslinked polystyrene (HCP/Fe(3)O(4)) for the sample preparation prior to 
      HPLC-MS/MS without deproteinization step. The results indicated recoveries of 
      85-107% for 14 sulfonamides, 85-120% for 13 beta-lactams, 89-115% for 4 
      tetracyclines, 82-119% for 14 quinolones, 82-115% for 8 macrolides, 97-109% for 4 
      nitrofurans, 84-115% for 10 nitroimidazoles, 89-114% for 3 phenicols, 86-111% for 
      3 lincosamides, 97-102% for 2 pleuromutilins, 72-88% for 4 macrocyclic lactones, 
      87-104% for 4 quinoxaline antibiotics, 76-119% for 21 benzimidazoles, 79-115% for 
      12 anthelmintics, 81-118% for 12 coccidiostats and 75-119 % for 5 unclassified 
      drugs, with relative standard deviations (RSDs) of less than 20%, and the LOQs 
      ranged from 0.05 to 1 mug kg(-1). This methodology was then applied to 
      field-collected real milk samples and trace levels of some veterinary drugs were 
      detected.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Melekhin, A O
AU  - Melekhin AO
AD  - Department of Chemistry, Lomonosov Moscow State University, Leninskie gory, 1/3, 
      119991 Moscow, Russia; Central Scientific Methodological Veterinary Laboratory, 
      Orangereynaya st., 23, 111622 Moscow, Russia.
FAU - Tolmacheva, V V
AU  - Tolmacheva VV
AD  - Department of Chemistry, Lomonosov Moscow State University, Leninskie gory, 1/3, 
      119991 Moscow, Russia.
FAU - Goncharov, N O
AU  - Goncharov NO
AD  - Department of Chemistry, Lomonosov Moscow State University, Leninskie gory, 1/3, 
      119991 Moscow, Russia.
FAU - Apyari, V V
AU  - Apyari VV
AD  - Department of Chemistry, Lomonosov Moscow State University, Leninskie gory, 1/3, 
      119991 Moscow, Russia. Electronic address: apyari@mail.ru.
FAU - Dmitrienko, S G
AU  - Dmitrienko SG
AD  - Department of Chemistry, Lomonosov Moscow State University, Leninskie gory, 1/3, 
      119991 Moscow, Russia.
FAU - Shubina, E G
AU  - Shubina EG
AD  - Central Scientific Methodological Veterinary Laboratory, Orangereynaya st., 23, 
      111622 Moscow, Russia.
FAU - Grudev, A I
AU  - Grudev AI
AD  - Central Scientific Methodological Veterinary Laboratory, Orangereynaya st., 23, 
      111622 Moscow, Russia.
LA  - eng
PT  - Journal Article
DEP - 20220331
PL  - England
TA  - Food Chem
JT  - Food chemistry
JID - 7702639
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Benzimidazoles)
RN  - 0 (Coccidiostats)
RN  - 0 (Lincosamides)
RN  - 0 (Macrolides)
RN  - 0 (Nitrofurans)
RN  - 0 (Nitroimidazoles)
RN  - 0 (Polystyrenes)
RN  - 0 (Quinolones)
RN  - 0 (Quinoxalines)
RN  - 0 (Sulfonamides)
RN  - 0 (Tetracyclines)
RN  - 0 (Veterinary Drugs)
RN  - 0 (beta-Lactams)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/analysis
MH  - Benzimidazoles/analysis
MH  - Chromatography, High Pressure Liquid/methods
MH  - *Coccidiostats/analysis
MH  - *Drug Residues/analysis
MH  - Lincosamides/analysis
MH  - Macrolides/analysis
MH  - Magnetic Phenomena
MH  - Milk/chemistry
MH  - *Nitrofurans/analysis
MH  - *Nitroimidazoles/analysis
MH  - Polystyrenes
MH  - *Quinolones/analysis
MH  - Quinoxalines/analysis
MH  - Solid Phase Extraction
MH  - Sulfonamides/analysis
MH  - Tandem Mass Spectrometry/methods
MH  - Tetracyclines/analysis
MH  - *Veterinary Drugs/analysis
MH  - beta-Lactams/analysis
OTO - NOTNLM
OT  - HPLC-MS/MS
OT  - Magnetic hypercrosslinked polystyrene
OT  - Magnetic solid-phase extraction
OT  - Milk
OT  - Multiclass analysis
OT  - Veterinary drugs
EDAT- 2022/04/10 06:00
MHDA- 2022/05/04 06:00
CRDT- 2022/04/09 20:07
PHST- 2021/12/08 00:00 [received]
PHST- 2022/03/28 00:00 [revised]
PHST- 2022/03/29 00:00 [accepted]
PHST- 2022/04/10 06:00 [pubmed]
PHST- 2022/05/04 06:00 [medline]
PHST- 2022/04/09 20:07 [entrez]
AID - S0308-8146(22)00828-7 [pii]
AID - 10.1016/j.foodchem.2022.132866 [doi]
PST - ppublish
SO  - Food Chem. 2022 Sep 1;387:132866. doi: 10.1016/j.foodchem.2022.132866. Epub 2022 
      Mar 31.