PMID- 35398765
OWN - NLM
STAT- MEDLINE
DCOM- 20220426
LR  - 20220426
IS  - 1095-7103 (Electronic)
IS  - 0021-9797 (Linking)
VI  - 619
DP  - 2022 Aug
TI  - Thin film nanoarchitectonics of layer-by-layer assembly with reduced graphene 
      oxide on intraocular lens for photothermal therapy of posterior capsular 
      opacification.
PG  - 348-358
LID - S0021-9797(22)00527-6 [pii]
LID - 10.1016/j.jcis.2022.03.132 [doi]
AB  - Due to development of surgical techniques and intraocular lens (IOL) implants, 
      vision can often be restored in cataracts patients. However, posterior capsular 
      opacification (PCO) has become the most common and challenging complication in 
      cataracts surgery. While various approaches such as surface modification and drug 
      prophylaxis have been investigated to prevent PCO development, there is no 
      standard treatment that is sufficiently safe and effective to meet clinical 
      demands. Near-infrared (NIR) light-triggered photothermal therapy is an 
      attractive noninvasive treatment for PCO prophylaxis. We fabricated a new type of 
      IOL with excellent biocompatibility, stability, and photothermal conversion 
      property. Polyethyleneimine (PEI) and graphene oxide (GO) were layer-by-layer 
      assembled on model polymethylmethacrylate and IOL substrates, and the thickness, 
      surface roughness, and wettability of the substrates with different numbers of 
      bilayers were evaluated. After the reduction of GO to reduced GO (rGO), a rGO/PEI 
      multilayer thin film with good stability and photothermal conversion capability 
      was obtained. The rGO/PEI multilayer coating was able to induce apoptosis in lens 
      epithelium cells under 808-nm NIR laser irradiation in vitro. Finally, rGO@IOL 
      was implanted into rabbit eyes, and the biocompatibility and ability to prevent 
      PCO were evaluated for 5 weeks. The rGO@IOL implant exhibited excellent PCO 
      prevention ability with the assistance of NIR irradiation and did not induce 
      obvious pathological effects in surrounding healthy tissues. The rGO@IOL implant 
      with good biocompatibility, good physicochemical stability, and excellent 
      photothermal conversion property shows promise for clinical application in PCO 
      prophylaxis.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Zhang, Chengshou
AU  - Zhang C
AD  - Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310020, PR China.
FAU - Guo, Quanshi
AU  - Guo Q
AD  - MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department 
      of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, PR 
      China.
FAU - Tong, Zongrui
AU  - Tong Z
AD  - MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department 
      of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, PR 
      China.
FAU - Chen, Silong
AU  - Chen S
AD  - Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310020, PR China.
FAU - Mao, Zhengwei
AU  - Mao Z
AD  - MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department 
      of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, PR 
      China. Electronic address: zwmao@zju.edu.cn.
FAU - Yu, Yibo
AU  - Yu Y
AD  - Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang 
      University, Hangzhou 310020, PR China. Electronic address: yuyibo@zju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20220402
PL  - United States
TA  - J Colloid Interface Sci
JT  - Journal of colloid and interface science
JID - 0043125
RN  - 0 (graphene oxide)
RN  - 7782-42-5 (Graphite)
SB  - IM
MH  - Animals
MH  - *Capsule Opacification/etiology/prevention & control
MH  - Epithelial Cells
MH  - Graphite
MH  - Humans
MH  - *Lenses, Intraocular/adverse effects
MH  - Photothermal Therapy
MH  - Rabbits
OTO - NOTNLM
OT  - Graphene oxide
OT  - Intraocular lens
OT  - Layer-by-layer thin film
OT  - Photothermal therapy
OT  - Posterior capsular opacification
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/04/11 06:00
MHDA- 2022/04/27 06:00
CRDT- 2022/04/10 20:31
PHST- 2022/01/20 00:00 [received]
PHST- 2022/03/16 00:00 [revised]
PHST- 2022/03/28 00:00 [accepted]
PHST- 2022/04/11 06:00 [pubmed]
PHST- 2022/04/27 06:00 [medline]
PHST- 2022/04/10 20:31 [entrez]
AID - S0021-9797(22)00527-6 [pii]
AID - 10.1016/j.jcis.2022.03.132 [doi]
PST - ppublish
SO  - J Colloid Interface Sci. 2022 Aug;619:348-358. doi: 10.1016/j.jcis.2022.03.132. 
      Epub 2022 Apr 2.