PMID- 35399018
OWN - NLM
STAT- MEDLINE
DCOM- 20220412
LR  - 20220412
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 102
IP  - 14
DP  - 2022 Apr 12
TI  - [Difficulties and challenges in pathological diagnosis of gastrointestinal 
      pancreatic neuroendocrine tumors].
PG  - 996-999
LID - 10.3760/cma.j.cn112137-20210812-01802 [doi]
AB  - In the 5th edition of WHO Classification of Digestive System Tumours, the 
      classification and designation of gastroenteropancreatic neuroendocrine neoplasm 
      (GEP-NEN) were updated, and G3 was redefined. Therefore, the differential 
      diagnosis between well-differentiated neuroendocrine tumour G3(NETG3) and poorly 
      differentiated neuroendocrine carcinomas (NEC) is both important and difficult, 
      which has important clinical treatment and prognostic significance. Based on the 
      latest WHO and 2020 Chinese consensus on pathological diagnosis of GEP-NEN, this 
      paper proposed a comprehensive analysis on the differential diagnosis of 
      gastrointestinal pancreatic neuroendocrine tumor from four aspects, including 
      tumor morphological differentiation、tumor proliferative activity, gene change and 
      disease progression. However, even with the above four diagnostic tools, there 
      are still some difficulties and challenges in the work of pathological diagnosis. 
      This paper briefly expounds and discusses them together, in order to improve the 
      clinical application value.
FAU - Luo, J
AU  - Luo J
AD  - Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, China.
FAU - Shi, Y F
AU  - Shi YF
AD  - Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - Gastro-enteropancreatic neuroendocrine tumor
SB  - IM
MH  - *Gastrointestinal Neoplasms/diagnosis
MH  - Humans
MH  - *Intestinal Neoplasms/diagnosis/drug therapy/pathology
MH  - *Neuroendocrine Tumors/diagnosis
MH  - *Pancreatic Neoplasms/pathology
MH  - *Stomach Neoplasms/drug therapy
EDAT- 2022/04/12 06:00
MHDA- 2022/04/13 06:00
CRDT- 2022/04/11 02:21
PHST- 2022/04/11 02:21 [entrez]
PHST- 2022/04/12 06:00 [pubmed]
PHST- 2022/04/13 06:00 [medline]
AID - 10.3760/cma.j.cn112137-20210812-01802 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2022 Apr 12;102(14):996-999. doi: 
      10.3760/cma.j.cn112137-20210812-01802.