PMID- 35399966
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 2211-5072 (Electronic)
IS  - 2211-5056 (Print)
IS  - 2211-5056 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Jan-Mar
TI  - Change of intraocular blood flow during treatment for thyroid eye disease.
PG  - 97-100
LID - 10.4103/tjo.tjo_2_22 [doi]
AB  - To report a sequential observational study of changes in the retinal and 
      choroidal blood flow during medical and surgical treatments for a thyroid eye 
      disease (TED) patient, using optical coherence tomography angiography (OCTA) and 
      laser speckle flowgraphy (LSFG). A 28-year-old man with a history of Graves' 
      disease diagnosed 8 months prior was presented in the active phase of TED. His 
      clinical activity score (CAS) was 6, but without diplopia or visual loss. 
      Intraocular pressure measurement was OD 20 mmHg and OS 24 mmHg. Thyrotropin 
      receptor antibody (TRAb) and thyroid-stimulating antibody levels were 18.8 IU/L 
      and 4347%. Magnetic resonance imaging revealed enlargement of both extraocular 
      muscles and fat compartments in both orbits. The patient underwent IV pulsed 
      steroid therapy (1 g/day, 3 days) followed by an oral prednisone for 1 month. His 
      CAS score decreased to 4. Bilateral orbital fat decompression decreased his final 
      CAS score to 1 in both eyes. Intraocular blood flow was measured using laser 
      speckle flowgraphy (LSFG), and OCTA was performed. Retinal blood flow increased 
      slightly, but choroidal blood flow showed a robust increase. Choroidal blood flow 
      measured using both LSFG and OCTA was negatively correlated with the CAS score 
      and TRAb. In our case report, the ocular perfusion, especially choroidal blood 
      flow, may decrease in active TED, which may be reversed by medical and surgical 
      treatment.
CI  - Copyright: (c) 2022 Taiwan J Ophthalmol.
FAU - Mimura, Masashi
AU  - Mimura M
AD  - Department of Ophthalmology, Osaka Medical and Pharmaceutical University, 
      Takatsuki, Japan.
FAU - Nishikawa, Yuko
AU  - Nishikawa Y
AD  - Department of Ophthalmology, Osaka Medical and Pharmaceutical University, 
      Takatsuki, Japan.
FAU - Inagaki, Keiko
AU  - Inagaki K
AD  - Department of Ophthalmology, Osaka Medical and Pharmaceutical University, 
      Takatsuki, Japan.
FAU - Sato, Yohei
AU  - Sato Y
AD  - Department of Ophthalmology, Osaka Medical and Pharmaceutical University, 
      Takatsuki, Japan.
FAU - Fujita, Yasushi
AU  - Fujita Y
AD  - Department of Ophthalmology, Osaka Medical and Pharmaceutical University, 
      Takatsuki, Japan.
FAU - Kikkawa, Don O
AU  - Kikkawa DO
AD  - Department of Ophthalmology, Division of Oculofacial Plastic and Reconstructive 
      Surgery, Shiley Eye Institute, University of California San Diego, San Diego, CA, 
      USA.
AD  - Department of Surgery, Division of Plastic Surgery, University of California San 
      Diego, San Diego, CA, USA.
LA  - eng
PT  - Case Reports
DEP - 20220228
PL  - India
TA  - Taiwan J Ophthalmol
JT  - Taiwan journal of ophthalmology
JID - 101582127
PMC - PMC8988972
OTO - NOTNLM
OT  - Laser speckle flowgraphy
OT  - optical coherence tomography angiography
OT  - thyroid eye disease
COIS- The authors declare that there are no conflicts of interests of this paper.
EDAT- 2022/04/12 06:00
MHDA- 2022/04/12 06:01
PMCR- 2022/02/28
CRDT- 2022/04/11 05:20
PHST- 2021/12/07 00:00 [received]
PHST- 2022/01/03 00:00 [accepted]
PHST- 2022/04/11 05:20 [entrez]
PHST- 2022/04/12 06:00 [pubmed]
PHST- 2022/04/12 06:01 [medline]
PHST- 2022/02/28 00:00 [pmc-release]
AID - TJO-12-97 [pii]
AID - 10.4103/tjo.tjo_2_22 [doi]
PST - epublish
SO  - Taiwan J Ophthalmol. 2022 Feb 28;12(1):97-100. doi: 10.4103/tjo.tjo_2_22. 
      eCollection 2022 Jan-Mar.