PMID- 35401010
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 15
DP  - 2022
TI  - Clinical Importance of FNDC-5 and Selectin-E mRNA Expression Among Type 2 
      Diabetics with and without Obesity.
PG  - 1011-1021
LID - 10.2147/DMSO.S352483 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is growing illnesses associated with 
      metabolic dysregulation such as obesity affecting a large population become 
      leading causes of death worldwide. Fibronectin type III domain-containing protein 
      5 (FNDC-5) and selectin-E were suggested to have effects on metabolism and 
      diabetes, therefore present study aimed to evaluate the clinical importance of 
      FNDC-5 and selectin-E among the T2DM patients with and without obesity. METHODS: 
      Study included cohort of 200 T2DM patients with and without obesity. We evaluated 
      FNDC-5, selectin-E mRNA expression as well as vitamin-D, and vitamin-B12 levels 
      in among the T2DM patients with and without obesity. RESULTS: Study observed 
      significant difference in biochemical parameters included in study. T2DM patients 
      with obesity had significantly higher fasting blood glucose levels (p<0.0001) and 
      HbA1c (glycated hemoglobin) (p<0.0001) compared to those T2DM patients without 
      obesity. T2DM patients with obesity also had higher systolic blood pressure 
      (p=0.001), LDL (low density lipoprotein) (p=0.02), TG (triglycerides) (p=0.02) 
      and cholesterol (p=0.01) compared to T2DM patients without obesity. The mRNA 
      expression of FNDC-5 (p<0.0001) was lower in T2DM patients with obesity compared 
      to T2DM patients without obesity. It was observed that the T2DM patients with 
      vitamin-D deficiency had significantly lower FNDC-5 mRNA expression (p=0.03) when 
      compared with those with sufficient vitamin-D level. T2DM patients with 
      clinically normal vitamin-B12 level expressed 0.60 fold FNDC-5 mRNA expression 
      while B12 deficient T2DM patients had 0.28 fold FNDC-5 mRNA expression (p=0.005). 
      No as such significant association was was observed with selectin-E. A negative 
      correlation of FNDC-5 mRNA expression with Post prandial glucose (mg/dl) (p=0.04) 
      and TG (mg/dl) (p=0.02) was observed. CONCLUSION: FNDC-5 down regulation was 
      observed with T2DM with obesity, vitamin-D and vitamin-B12 deficiency suggesting 
      obesity, vitamin-D and vitamin-B12 deficiency could be the factor for FNDC-5 
      down-regulation leading to worseness or progression of disease. We suggest that 
      FNDC-5 down-regulation could be used as an indicator for T2DM worseness and 
      development of other associated complications.
CI  - (c) 2022 Verma et al.
FAU - Verma, Amit K
AU  - Verma AK
AD  - Department of Biotechnology, Jamia Millia Islamia University, New Delhi, India.
AD  - Department of Zoology and Environmental Sciences, Gurukul Kangri Vishwavidyalaya, 
      Haridwar, India.
FAU - Aladel, Alanoud
AU  - Aladel A
AUID- ORCID: 0000-0002-1441-607X
AD  - Department of Community Health Sciences, College of Applied Medical Sciences, 
      King Saud University, Riyadh, Saudi Arabia.
FAU - Dabeer, Sadaf
AU  - Dabeer S
AUID- ORCID: 0000-0002-0564-4185
AD  - Department of Exercise Science and Sport Management, Kennesaw State University, 
      Kennesaw, GA, USA.
FAU - Ahmad, Irfan
AU  - Ahmad I
AUID- ORCID: 0000-0002-9500-4623
AD  - Department of Clinical Laboratory Science, College of Applied Medical Sciences, 
      King Khalid University, Abha, Saudi Arabia.
FAU - Khan, Mohammad Idreesh
AU  - Khan MI
AD  - Department of Clinical Nutrition, College of Applied Health Sciences in Arras, 
      Qassim University, Buraidah, Saudi Arabia.
FAU - Almutairi, Malak Ghazi
AU  - Almutairi MG
AD  - Department of nutrition, Almethnab General Hospital, Qassim Health Cluster, 
      Ministry of Health, Al Mithnab, Saudi Arabia.
FAU - Al-Harbi, Alhanouf I
AU  - Al-Harbi AI
AUID- ORCID: 0000-0003-0889-2886
AD  - Department of Medical Laboratory, College of Applied Medical Sciences, Taibah 
      University, Yanbu, Saudi Arabia.
FAU - Beg, Mirza Masroor Ali
AU  - Beg MMA
AUID- ORCID: 0000-0002-4519-721X
AD  - Faculty of Medicine, Ala-Too International University, Bishkek, Kyrgyzstan.
AD  - Centre for Promotion of Medical Research, Ala-Too International University, 
      Bishkek, Kyrgyzstan.
LA  - eng
PT  - Journal Article
DEP - 20220402
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC8986209
OTO - NOTNLM
OT  - FNDC-5
OT  - expression
OT  - mRNA
OT  - obesity
OT  - selectin-E
OT  - type 2 diabetes mellitus
COIS- The authors report no conflicts of interest in this work.
EDAT- 2022/04/12 06:00
MHDA- 2022/04/12 06:01
PMCR- 2022/04/02
CRDT- 2022/04/11 05:26
PHST- 2021/12/04 00:00 [received]
PHST- 2022/03/10 00:00 [accepted]
PHST- 2022/04/11 05:26 [entrez]
PHST- 2022/04/12 06:00 [pubmed]
PHST- 2022/04/12 06:01 [medline]
PHST- 2022/04/02 00:00 [pmc-release]
AID - 352483 [pii]
AID - 10.2147/DMSO.S352483 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2022 Apr 2;15:1011-1021. doi: 10.2147/DMSO.S352483. 
      eCollection 2022.