PMID- 35401409
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 13
DP  - 2022
TI  - Thoracic Excursion Is a Biomarker for Evaluating Respiratory Function in 
      Amyotrophic Lateral Sclerosis.
PG  - 853469
LID - 10.3389/fneur.2022.853469 [doi]
LID - 853469
AB  - OBJECTIVE: To evaluate the usefulness of thoracic excursion as a biomarker in 
      patients with amyotrophic lateral sclerosis (ALS). METHODS: We measured the 
      forced the vital capacity (FVC), thoracic excursion, baseline-to-peak 
      diaphragmatic compound muscle action potential (DCMAP) amplitude, diaphragm 
      thickness at full inspiration (DTfi), Medical Research Council (MRC) sum score 
      for muscle strength, and arterial partial pressures of oxygen and carbon dioxide 
      and administered the Amyotrophic Lateral Sclerosis Functional Rating 
      Scale-Revised (ALSFRS-R) and modified Medical Research Council (mMRC) Dyspnea 
      Scale. The test-retest reliability of thoracic excursion was determined. RESULTS 
      AND CONCLUSIONS: Thirty-four patients with ALS and 26 age- and sex-matched 
      healthy participants were enrolled. Thoracic excursion measurement had excellent 
      test-retest reliability (intraclass coefficient: 0.974). Thoracic excursion was 
      more strongly correlated with FVC (r = 0.678, p < 0.001) than DCMAP amplitude (r 
      = 0.501, p = 0.003) and DTfi (r = 0.597, p < 0.001). It was also correlated with 
      ALSFRS-R score (r = 0.610, p < 0.001), MRC sum score (r = 0.470, p = 0.005), and 
      mMRC Dyspnea Scale score (r = -0.446, p = 0.008) and was the most sensitive 
      parameter for assessing dyspnea and FVC. Thoracic excursion decreased as FVC 
      declined in the early and late stages, there were no differences in DCMAP 
      amplitude and DTfi between the early and late stages, and ALSFRS-R score and MRC 
      sum score decreased only in the late stage. Thoracic excursion was well 
      correlated with respiratory function and is useful for predicting respiratory and 
      general dysfunction in patients with ALS regardless of stage.
CI  - Copyright (c) 2022 Iguchi, Mano, Iwasa, Ozaki, Yamada, Kikutsuji, Kido and Sugie.
FAU - Iguchi, Naohiko
AU  - Iguchi N
AD  - Department of Neurology, Nara Medical University, Kashihara, Japan.
FAU - Mano, Tomoo
AU  - Mano T
AD  - Department of Neurology, Nara Medical University, Kashihara, Japan.
AD  - Department of Rehabilitation Medicine, Nara Medical University, Kashihara, Japan.
FAU - Iwasa, Naoki
AU  - Iwasa N
AD  - Department of Neurology, Nara Medical University, Kashihara, Japan.
FAU - Ozaki, Maki
AU  - Ozaki M
AD  - Department of Neurology, Nara Medical University, Kashihara, Japan.
FAU - Yamada, Nanami
AU  - Yamada N
AD  - Department of Neurology, Nara Medical University, Kashihara, Japan.
FAU - Kikutsuji, Naoya
AU  - Kikutsuji N
AD  - Department of Neurology, Nara Medical University, Kashihara, Japan.
FAU - Kido, Akira
AU  - Kido A
AD  - Department of Rehabilitation Medicine, Nara Medical University, Kashihara, Japan.
FAU - Sugie, Kazuma
AU  - Sugie K
AD  - Department of Neurology, Nara Medical University, Kashihara, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220323
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC8984343
OTO - NOTNLM
OT  - amyotrophic lateral sclerosis
OT  - biomarker
OT  - pulmonary function test
OT  - respiratory function
OT  - thoracic excursion
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/04/12 06:00
MHDA- 2022/04/12 06:01
PMCR- 2022/03/23
CRDT- 2022/04/11 05:27
PHST- 2022/01/12 00:00 [received]
PHST- 2022/02/25 00:00 [accepted]
PHST- 2022/04/11 05:27 [entrez]
PHST- 2022/04/12 06:00 [pubmed]
PHST- 2022/04/12 06:01 [medline]
PHST- 2022/03/23 00:00 [pmc-release]
AID - 10.3389/fneur.2022.853469 [doi]
PST - epublish
SO  - Front Neurol. 2022 Mar 23;13:853469. doi: 10.3389/fneur.2022.853469. eCollection 
      2022.