PMID- 35402037
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 1507-1367 (Print)
IS  - 2083-4640 (Electronic)
IS  - 1507-1367 (Linking)
VI  - 27
IP  - 1
DP  - 2022
TI  - Dosimetric accuracy of three dose calculation algorithms for radiation therapy of 
      in situ non-small cell lung carcinoma.
PG  - 86-96
LID - 10.5603/RPOR.a2022.0013 [doi]
AB  - BACKGROUND: Study determines differences in calculated dose distributions for 
      non-small cell lung carcinoma (NSC LC) patients. NSC LC cases were investigated, 
      being the most common lung cancer treated by radiotherapy in our clinical 
      practice. MATERIALS AND METHODS: A retrospective study of 15 NSCLC patient dose 
      distributions originally calculated using standard superposition (SS) and 
      recalculated using collapsed cone (CC ) and Monte Carlo (MC) based algorithm 
      expressed as dose to medium in medium (MCD(m)) and dose to water in medium 
      (MCD(w,)) was performed so that prescribed dose covers at least 99% of the gross 
      target volume (GTV). Statistical analysis was performed for differences of 
      conformity index (CI), heterogeneity index (HI), gradient index (GI), dose 
      delivered to 2% of the volume (D(2%)), mean dose (D(mean)) and percentage of 
      volumes covered by prescribed dose (V(70Gy)). For organs at risk (OARs), D(mean) 
      and percentage of volume receiving 20 Gy and 5Gy (V(20Gy), V(5Gy)) were analysed. 
      RESULTS: Statistically significant difference for GTVs was observed between 
      MCD(w) and SS algorithm in mean dose only. For planning target volumes (PTVs), 
      statistically significant differences were observed in prescribed dose coverage 
      for CC, MCD(m) and MCD(w). The differences in mean CI value for the CC algorithm 
      and mean HI value for MCD(m) and MCD(w) were statistically significant. There is 
      a statistically significant difference in the number of MUs for MCD(m) and MCD(w) 
      compared to SS. CONCLUSION: All investigated algorithms succeed in managing the 
      restrictive conditions of the clinical goals. This study shows the drawbacks of 
      the CC algorithm compared to other algorithms used.
CI  - (c) 2022 Greater Poland Cancer Centre.
FAU - Kolacio, Manda Svabic
AU  - Kolacio MS
AD  - Medical Physics Department, Clinical Hospital Center Rijeka, Rijeka, Croatia.
FAU - Rajlic, David
AU  - Rajlic D
AD  - Medical Physics Department, Clinical Hospital Center Rijeka, Rijeka, Croatia.
FAU - Radojcic, Milan
AU  - Radojcic M
AD  - Clinic for Radiotherapy and Oncology, Clinical Hospital Center Rijeka, Rijeka, 
      Croatia.
FAU - Radojcic, Deni Smilovic
AU  - Radojcic DS
AD  - Medical Physics Department, Clinical Hospital Center Rijeka, Rijeka, Croatia.
AD  - Department of Medical Physics and Biophysics, University of Rijeka Faculty of 
      Medicine, Rijeka, Croatia.
FAU - Obajdin, Nevena
AU  - Obajdin N
AD  - Medical Physics Department, Clinical Hospital Center Rijeka, Rijeka, Croatia.
FAU - Debeljuh, Dea Dundara
AU  - Debeljuh DD
AD  - Medical Physics Department, Clinical Hospital Center Rijeka, Rijeka, Croatia.
AD  - Department of Medical Physics and Biophysics, University of Rijeka Faculty of 
      Medicine, Rijeka, Croatia.
AD  - Radiology Department, General Hospital Pula, Pula, Croatia.
FAU - Jurkovic, Slaven
AU  - Jurkovic S
AD  - Medical Physics Department, Clinical Hospital Center Rijeka, Rijeka, Croatia.
AD  - Department of Medical Physics and Biophysics, University of Rijeka Faculty of 
      Medicine, Rijeka, Croatia.
LA  - eng
PT  - Journal Article
DEP - 20220322
PL  - Poland
TA  - Rep Pract Oncol Radiother
JT  - Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer 
      Center in Poznan and Polish Society of Radiation Oncology
JID - 100885761
PMC - PMC8989458
OTO - NOTNLM
OT  - Monaco
OT  - TPS
OT  - XiO standard superposition
OT  - non-small cell lung carcinoma
OT  - radiation therapy
COIS- Conflict of interest No conflict of interest.
EDAT- 2022/04/12 06:00
MHDA- 2022/04/12 06:01
PMCR- 2022/03/22
CRDT- 2022/04/11 05:30
PHST- 2021/11/09 00:00 [received]
PHST- 2022/01/19 00:00 [accepted]
PHST- 2022/04/11 05:30 [entrez]
PHST- 2022/04/12 06:00 [pubmed]
PHST- 2022/04/12 06:01 [medline]
PHST- 2022/03/22 00:00 [pmc-release]
AID - rpor-27-1-86 [pii]
AID - 10.5603/RPOR.a2022.0013 [doi]
PST - epublish
SO  - Rep Pract Oncol Radiother. 2022 Mar 22;27(1):86-96. doi: 10.5603/RPOR.a2022.0013. 
      eCollection 2022.