PMID- 35402762
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220413
IS  - 2472-1972 (Electronic)
IS  - 2472-1972 (Linking)
VI  - 6
IP  - 5
DP  - 2022 May 1
TI  - A Case of Methimazole-Induced Acute Pancreatitis With an HLA Allele Causing 
      Antithyroid Drug-Induced Agranulocytosis.
PG  - bvac038
LID - 10.1210/jendso/bvac038 [doi]
LID - bvac038
AB  - Among the side effects of methimazole (MMI) for the treatment of Graves' disease, 
      MMI-induced acute pancreatitis (MIP) is a rare adverse reaction, with only 7 
      cases being reported to date. However, 2 large-scale population-based studies 
      recently revealed that the risk of MIP was significantly higher, ranging from 
      0.02% to 0.56%. Although MIP is common in middle-aged and elderly Asian women, 
      its pathogenesis remains largely unknown. We herein present a case of a 
      72-year-old Japanese woman with Graves' disease who developed MIP 12 days after 
      the initiation of MMI. The MMI was discontinued, the patient was switched to 
      propylthiouracil (PTU) therapy, and pancreatitis gradually resolved. Serological 
      human leukocyte antigen (HLA) typing identified HLA-DRB1*08:03:02. This HLA 
      allele was previously detected in a patient with MIP and is one of the major risk 
      factors for agranulocytosis induced by antithyroid drugs, including PTU as well 
      as MMI. In cases of MIP, PTU is being considered as an alternative to MMI; 
      however, its safety needs further investigation and patients require close 
      monitoring after the switch to PTU. Further studies are warranted, particularly 
      on the relationship between MIP and the presence of HLA alleles causing 
      antithyroid drug-induced agranulocytosis.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the 
      Endocrine Society.
FAU - Yoshimura, Yusuke
AU  - Yoshimura Y
AUID- ORCID: 0000-0002-7358-9747
AD  - Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 
      105-8470, Japan.
FAU - Tatsushima, Keita
AU  - Tatsushima K
AD  - Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 
      105-8470, Japan.
FAU - Goshima, Yukiko
AU  - Goshima Y
AD  - Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 
      105-8470, Japan.
FAU - Hoshino, Yoshitomo
AU  - Hoshino Y
AD  - Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 
      105-8470, Japan.
FAU - Nakashima, Saki
AU  - Nakashima S
AD  - Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 
      105-8470, Japan.
FAU - Inaba, Tatsuro
AU  - Inaba T
AD  - Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 
      105-8470, Japan.
FAU - Ikeda, Sara
AU  - Ikeda S
AD  - Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 
      105-8470, Japan.
FAU - Hattori, Daisuke
AU  - Hattori D
AD  - Department of Gastroenterology, Toranomon Hospital, Minato-Ku, Tokyo 105-8470, 
      Japan.
FAU - Koyama, Rikako
AU  - Koyama R
AD  - Department of Gastroenterology, Toranomon Hospital, Minato-Ku, Tokyo 105-8470, 
      Japan.
FAU - Imamura, Tsunao
AU  - Imamura T
AD  - Department of Gastroenterology, Toranomon Hospital, Minato-Ku, Tokyo 105-8470, 
      Japan.
FAU - Takeshita, Akira
AU  - Takeshita A
AUID- ORCID: 0000-0003-3685-9055
AD  - Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 
      105-8470, Japan.
AD  - Okinaka Memorial Institute for Medical Research, Minato-ku, Tokyo 105-8470, 
      Japan.
FAU - Takeuchi, Yasuhiro
AU  - Takeuchi Y
AD  - Department of Endocrinology and Metabolism, Toranomon Hospital, Minato-ku, Tokyo 
      105-8470, Japan.
LA  - eng
PT  - Case Reports
DEP - 20220310
PL  - United States
TA  - J Endocr Soc
JT  - Journal of the Endocrine Society
JID - 101697997
PMC - PMC8989154
OTO - NOTNLM
OT  - Graves' disease
OT  - acute pancreatitis
OT  - human leukocyte antigen
OT  - methimazole
EDAT- 2022/04/12 06:00
MHDA- 2022/04/12 06:01
PMCR- 2022/03/10
CRDT- 2022/04/11 05:32
PHST- 2022/01/18 00:00 [received]
PHST- 2022/04/11 05:32 [entrez]
PHST- 2022/04/12 06:00 [pubmed]
PHST- 2022/04/12 06:01 [medline]
PHST- 2022/03/10 00:00 [pmc-release]
AID - bvac038 [pii]
AID - 10.1210/jendso/bvac038 [doi]
PST - epublish
SO  - J Endocr Soc. 2022 Mar 10;6(5):bvac038. doi: 10.1210/jendso/bvac038. eCollection 
      2022 May 1.