PMID- 35403349
OWN - NLM
STAT- MEDLINE
DCOM- 20220929
LR  - 20221229
IS  - 1865-1682 (Electronic)
IS  - 1865-1674 (Print)
IS  - 1865-1674 (Linking)
VI  - 69
IP  - 5
DP  - 2022 Sep
TI  - Phylodynamic and phylogeographic reconstruction of porcine reproductive and 
      respiratory syndrome virus (PRRSV) in Europe: Patterns and determinants.
PG  - e2175-e2184
LID - 10.1111/tbed.14556 [doi]
AB  - Porcine reproductive and respiratory syndrome (PRRS) is among the most 
      devastating diseases affecting the pig industry. Despite vaccines having been 
      available for decades, the remarkable genetic variability of this virus, leading 
      to poor cross-protection, has limited their efficacy, and other measures must be 
      adopted to effectively control the viral circulation. Some recent studies have 
      investigated the factors involved in viral spreading and persistence, at least at 
      the local level. However, despite the topic's relevance, no statistically 
      grounded evidence is currently available evaluating the variables more involved 
      in porcine reproductive and respiratory syndrome virus (PRRSV) epidemiological 
      success at a broader scale, such as the European scale. In the present study, an 
      extensive phylodynamic and phylogeographic analysis was performed on more than 
      1000 ORF5 sequences to investigate the history, dynamics and spreading patterns 
      of PRRSV within European borders. Moreover, several potential predictors, 
      representative of swine population features and trade, human population, economy 
      and geographic characteristics, were evaluated through a specifically designed 
      generalized linear model (GLM) to assess their weight on viral migration rate 
      between countries over time. Although pig stock density, mean PRRSV strain 
      genetic diversity, investments in agriculture (including a likely role of 
      vaccination) and farmer education were involved to a certain extent, the major 
      determinant was proven to be by far the live pig trade. Providing a robust 
      depiction of PRRSV European molecular epidemiology patterns and determinants, the 
      present study could contribute to a more rational allocation of limited resources 
      based on an effective prioritization of control measures.
CI  - (c) 2022 The Authors. Transboundary and Emerging Diseases published by Wiley-VCH 
      GmbH.
FAU - Franzo, Giovanni
AU  - Franzo G
AUID- ORCID: 0000-0003-2991-217X
AD  - Department of Animal Medicine, Production and Health (MAPS), University of Padua, 
      Legnaro PD, Italy.
FAU - Faustini, Giulia
AU  - Faustini G
AD  - Department of Animal Medicine, Production and Health (MAPS), University of Padua, 
      Legnaro PD, Italy.
FAU - Legnardi, Matteo
AU  - Legnardi M
AD  - Department of Animal Medicine, Production and Health (MAPS), University of Padua, 
      Legnaro PD, Italy.
FAU - Cecchinato, Mattia
AU  - Cecchinato M
AD  - Department of Animal Medicine, Production and Health (MAPS), University of Padua, 
      Legnaro PD, Italy.
FAU - Drigo, Michele
AU  - Drigo M
AD  - Department of Animal Medicine, Production and Health (MAPS), University of Padua, 
      Legnaro PD, Italy.
FAU - Tucciarone, Claudia Maria
AU  - Tucciarone CM
AD  - Department of Animal Medicine, Production and Health (MAPS), University of Padua, 
      Legnaro PD, Italy.
LA  - eng
PT  - Journal Article
DEP - 20220422
PL  - Germany
TA  - Transbound Emerg Dis
JT  - Transboundary and emerging diseases
JID - 101319538
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Europe/epidemiology
MH  - Humans
MH  - Phylogeny
MH  - Phylogeography
MH  - *Porcine Reproductive and Respiratory Syndrome/epidemiology/prevention & control
MH  - *Porcine respiratory and reproductive syndrome virus/genetics
MH  - Swine
MH  - *Swine Diseases
MH  - Vaccination/veterinary
MH  - *Viral Vaccines
PMC - PMC9790212
OTO - NOTNLM
OT  - Europe
OT  - GLM
OT  - ORF5
OT  - PRRSV
OT  - control
OT  - phylodynamics
OT  - phylogeography
COIS- The authors declare no conflicts of interest.
EDAT- 2022/04/12 06:00
MHDA- 2022/09/30 06:00
PMCR- 2022/12/25
CRDT- 2022/04/11 05:35
PHST- 2022/03/08 00:00 [revised]
PHST- 2022/02/04 00:00 [received]
PHST- 2022/04/06 00:00 [accepted]
PHST- 2022/04/12 06:00 [pubmed]
PHST- 2022/09/30 06:00 [medline]
PHST- 2022/04/11 05:35 [entrez]
PHST- 2022/12/25 00:00 [pmc-release]
AID - TBED14556 [pii]
AID - 10.1111/tbed.14556 [doi]
PST - ppublish
SO  - Transbound Emerg Dis. 2022 Sep;69(5):e2175-e2184. doi: 10.1111/tbed.14556. Epub 
      2022 Apr 22.