PMID- 35404941
OWN - NLM
STAT- MEDLINE
DCOM- 20220413
LR  - 20220621
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 17
IP  - 4
DP  - 2022
TI  - Thrombus characteristics evaluated by acute optical coherence tomography in ST 
      elevation myocardial Infarction.
PG  - e0266634
LID - 10.1371/journal.pone.0266634 [doi]
LID - e0266634
AB  - AIMS: ST elevation myocardial infarction (STEMI) is caused by an occlusive 
      thrombosis of a coronary artery. We wanted to assess if the thrombus can be 
      characterized according to erythrocyte content and age using intravascular 
      optical coherence tomography (OCT) in a clinical setting. METHODS AND RESULTS: We 
      performed manual thrombus aspiration in 66 STEMI patients. OCT was done of the 
      thrombus remnants after aspiration. A light intensity ratio was measured through 
      the thrombus. Forty two of the aspirates had thrombus which could be analyzed 
      histomorphologically for analysis of erythrocyte and platelet content, and to 
      determine the age of thrombus as fresh, lytic or organized. There were 11 red, 21 
      white and 10 mixed thrombi. Furthermore, 36 aspirates had elements of fresh, 7 of 
      lytic and 8 of organized thrombi. There was no correlation between colour and 
      age. OCT appearance could not predict erythrocyte or platelet content. The light 
      intensity ratios were not significantly different in fresh, lytic or organized 
      thrombi. CONCLUSION: OCT could not differentiate between red and white thrombi, 
      nor determine thrombus age.
FAU - Eriksen, Erlend
AU  - Eriksen E
AUID- ORCID: 0000-0003-0793-8870
AD  - Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
AD  - Department of Clinical Science, University of Bergen, Bergen, Norway.
FAU - Herstad, Jon
AU  - Herstad J
AD  - Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
FAU - Pertiwi, Kartika Ratna
AU  - Pertiwi KR
AUID- ORCID: 0000-0002-0996-6210
AD  - Department of Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam, The 
      Netherlands.
FAU - Tuseth, Vegard
AU  - Tuseth V
AD  - Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
AD  - Department of Clinical Science, University of Bergen, Bergen, Norway.
FAU - Nordrehaug, Jan Erik
AU  - Nordrehaug JE
AD  - Department of Clinical Science, University of Bergen, Bergen, Norway.
FAU - Bleie, Oyvind
AU  - Bleie O
AD  - Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
FAU - van der Wal, Allard C
AU  - van der Wal AC
AD  - Department of Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam, The 
      Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20220411
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - *Coronary Thrombosis/diagnostic imaging
MH  - Coronary Vessels
MH  - Humans
MH  - *Myocardial Infarction/diagnostic imaging
MH  - *Percutaneous Coronary Intervention
MH  - *ST Elevation Myocardial Infarction/diagnostic imaging
MH  - Thrombectomy
MH  - Tomography, Optical Coherence
PMC - PMC9000063
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/04/12 06:00
MHDA- 2022/04/14 06:00
PMCR- 2022/04/11
CRDT- 2022/04/11 17:40
PHST- 2021/11/17 00:00 [received]
PHST- 2022/03/23 00:00 [accepted]
PHST- 2022/04/11 17:40 [entrez]
PHST- 2022/04/12 06:00 [pubmed]
PHST- 2022/04/14 06:00 [medline]
PHST- 2022/04/11 00:00 [pmc-release]
AID - PONE-D-21-35338 [pii]
AID - 10.1371/journal.pone.0266634 [doi]
PST - epublish
SO  - PLoS One. 2022 Apr 11;17(4):e0266634. doi: 10.1371/journal.pone.0266634. 
      eCollection 2022.