PMID- 35404942
OWN - NLM
STAT- MEDLINE
DCOM- 20220413
LR  - 20230517
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 17
IP  - 4
DP  - 2022
TI  - Exposure to arsenic and level of Vitamin D influence the number of Th17 cells and 
      production of IL-17A in human peripheral blood mononuclear cells in adults.
PG  - e0266168
LID - 10.1371/journal.pone.0266168 [doi]
LID - e0266168
AB  - There is limited evidence on the effects of environmental exposure to arsenic 
      (As) on the immune system in adults. In a population-based study, we have found 
      that urinary As (UAs), and its metabolites [inorganic As (InAs), monomethylated 
      arsenicals (MMA+3/+5), and dimethylated arsenicals (DMA+3/+5)] modulate or 
      influence the number of T-helper 17 (Th17) cells and IL-17A cytokine production. 
      In non-smoking women, we observed that UAs and DMA+3/+5 were associated with 
      changes in Th17 cell numbers in a nonlinear fashion. In smoking males, we found 
      that UAs was associated with a significant decrease of Th17 cell numbers. Similar 
      association was observed among non-smoking males. Likewise, UAs, DMA+3/+5 and 
      MMA+3/+5 were associated with diminished production of IL-17A among non-smoking 
      males. When stratified by Vitamin D levels defined as sufficient (>/=20 ng/ml) and 
      insufficient (<20 ng/ml), we found a substancial decrease in Th17 cell numbers 
      among those with insufficient levels. Individuals with sufficient VitD levels 
      demonstrated significant inhibition of IL-17A production in non-smoking males. 
      Collectively, we find that exposure to As via drinking water is associated with 
      alterations in Th17 numbers and IL-17A production, and that these associations 
      may be modified by Vitamin D status. Our findings have significance for health 
      outcomes associated with As exposure.
FAU - Parvez, Faruque
AU  - Parvez F
AUID- ORCID: 0000-0002-5079-3825
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University, New York, New York, United States of America.
FAU - Lauer, Fredine T
AU  - Lauer FT
AUID- ORCID: 0000-0002-5460-4606
AD  - Department of Pharmaceutical Sciences, University of New Mexico College of 
      Pharmacy, Albuquerque, New Mexico, United States of America.
FAU - Factor-Litvak, Pam
AU  - Factor-Litvak P
AD  - Department of Epidemiology, Mailman School of Public Health, Columbia University, 
      New York, New York, United States of America.
FAU - Islam, Tariqul
AU  - Islam T
AD  - University of Chicago and Columbia University Field Research Office, Dhaka, 
      Bangladesh.
FAU - Eunus, Mahbubul
AU  - Eunus M
AD  - University of Chicago and Columbia University Field Research Office, Dhaka, 
      Bangladesh.
FAU - Horayara, M Abu
AU  - Horayara MA
AD  - University of Chicago and Columbia University Field Research Office, Dhaka, 
      Bangladesh.
FAU - Rahman, Mizanour
AU  - Rahman M
AD  - University of Chicago and Columbia University Field Research Office, Dhaka, 
      Bangladesh.
FAU - Sarwar, Golam
AU  - Sarwar G
AD  - University of Chicago and Columbia University Field Research Office, Dhaka, 
      Bangladesh.
FAU - Ahsan, Habibul
AU  - Ahsan H
AD  - Department of Health Studies, University of Chicago, Chicago, Illinois, United 
      States of America.
FAU - Graziano, Joseph H
AU  - Graziano JH
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University, New York, New York, United States of America.
FAU - Burchiel, Scott W
AU  - Burchiel SW
AUID- ORCID: 0000-0001-9509-0149
AD  - Department of Pharmaceutical Sciences, University of New Mexico College of 
      Pharmacy, Albuquerque, New Mexico, United States of America.
LA  - eng
SI  - figshare/10.6084/m9.figshare.17316374
GR  - P30 ES009089/ES/NIEHS NIH HHS/United States
GR  - R01 ES019968/ES/NIEHS NIH HHS/United States
GR  - R01 ES023888/ES/NIEHS NIH HHS/United States
GR  - P42 ES010349/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20220411
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Arsenicals)
RN  - 0 (Interleukin-17)
RN  - 0 (Vitamins)
RN  - 1406-16-2 (Vitamin D)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Adult
MH  - *Arsenic/analysis
MH  - *Arsenicals
MH  - Environmental Exposure/adverse effects
MH  - Female
MH  - Humans
MH  - Interleukin-17
MH  - Leukocytes, Mononuclear/metabolism
MH  - Male
MH  - Th17 Cells/metabolism
MH  - Vitamin D/pharmacology
MH  - Vitamins
PMC - PMC9000092
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/04/12 06:00
MHDA- 2022/04/14 06:00
PMCR- 2022/04/11
CRDT- 2022/04/11 17:40
PHST- 2021/07/12 00:00 [received]
PHST- 2022/03/16 00:00 [accepted]
PHST- 2022/04/11 17:40 [entrez]
PHST- 2022/04/12 06:00 [pubmed]
PHST- 2022/04/14 06:00 [medline]
PHST- 2022/04/11 00:00 [pmc-release]
AID - PONE-D-21-22733 [pii]
AID - 10.1371/journal.pone.0266168 [doi]
PST - epublish
SO  - PLoS One. 2022 Apr 11;17(4):e0266168. doi: 10.1371/journal.pone.0266168. 
      eCollection 2022.