PMID- 35405947 OWN - NLM STAT- MEDLINE DCOM- 20220413 LR - 20220423 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 14 IP - 7 DP - 2022 Mar 23 TI - Optimal Obesity- and Lipid-Related Indices for Predicting Metabolic Syndrome in Chronic Kidney Disease Patients with and without Type 2 Diabetes Mellitus in China. LID - 10.3390/nu14071334 [doi] LID - 1334 AB - Existing obesity- and lipid-related indices are inconsistent with metabolic syndrome (MetS) in chronic kidney disease (CKD) patients. We compared seven indicators, including waist circumference (WC), body mass index (BMI), visceral fat area (VFA), subcutaneous fat area (SFA), visceral adiposity index (VAI), Chinese VAI and lipid accumulation product (LAP), to evaluate their ability to predict MetS in CKD patients with and without Type 2 diabetes mellitus (T2DM) under various criteria. Multivariate logistic regression analysis was used to investigate the independent associations between the indices and metabolic syndrome among 547 non-dialysis CKD patients, aged >/=18 years. The predictive power of these indices was assessed using receiver operating characteristic (ROC) curve analysis. After adjusting for potential confounders, the correlation between VAI and MetS was strongest based on the optimal cut-off value of 1.51 (sensitivity 86.84%, specificity 91.18%) and 2.35 (sensitivity 83.54%, specificity 86.08%), with OR values of 40.585 (8.683-189.695) and 5.076 (1.247-20.657) for males and females with CKD and T2DM. In CKD patients without T2DM, based on the optimal cut-off values of 1.806 (sensitivity 98.11%, specificity 72.73%) and 3.11 (sensitivity 84.62%, specificity 83.82%), the OR values were 7.514 (3.757-15.027) and 3.008 (1.789-5.056) for males and females, respectively. The area under ROC curve (AUC) and Youden index of VAI were the highest among the seven indexes, indicating its superiority in predicting MetS in both male and female CKD patients, especially those with T2DM. FAU - Li, Hangtian AU - Li H AD - National Clinical Research Center for Kidney Diseases, State Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, Beijing 100853, China. AD - School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. FAU - Wang, Qian AU - Wang Q AD - National Clinical Research Center for Kidney Diseases, State Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, Beijing 100853, China. FAU - Ke, Jianghua AU - Ke J AD - National Clinical Research Center for Kidney Diseases, State Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, Beijing 100853, China. AD - School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. FAU - Lin, Wenwen AU - Lin W AD - National Clinical Research Center for Kidney Diseases, State Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, Beijing 100853, China. AD - School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. FAU - Luo, Yayong AU - Luo Y AD - National Clinical Research Center for Kidney Diseases, State Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, Beijing 100853, China. AD - School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. FAU - Yao, Jin AU - Yao J AD - National Clinical Research Center for Kidney Diseases, State Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, Beijing 100853, China. AD - School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. FAU - Zhang, Weiguang AU - Zhang W AD - National Clinical Research Center for Kidney Diseases, State Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, Beijing 100853, China. FAU - Zhang, Li AU - Zhang L AD - National Clinical Research Center for Kidney Diseases, State Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, Beijing 100853, China. FAU - Duan, Shuwei AU - Duan S AD - National Clinical Research Center for Kidney Diseases, State Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, Beijing 100853, China. FAU - Dong, Zheyi AU - Dong Z AD - National Clinical Research Center for Kidney Diseases, State Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, Beijing 100853, China. FAU - Chen, Xiangmei AU - Chen X AD - National Clinical Research Center for Kidney Diseases, State Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, Beijing 100853, China. AD - School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China. LA - eng GR - D17110700280000/Science & Technology Project of Beijing/ GR - D171100002817002/Science & Technology Project of Beijing/ GR - D181100000118002/Science & Technology Project of Beijing/ GR - D181100000118004/Science & Technology Project of Beijing/ GR - 82030025/National Natural Science Foundation of China/ GR - Project No. 32141005/National Natural Science Foundation of China/ GR - No. 2018YFC1704203/National Key Research and Development Program of China/ PT - Journal Article DEP - 20220323 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Lipids) SB - IM MH - Adiposity MH - Adolescent MH - Adult MH - Body Mass Index MH - China/epidemiology MH - *Diabetes Mellitus, Type 2/complications MH - Female MH - Humans MH - Lipids MH - Male MH - *Metabolic Syndrome/complications/diagnosis MH - Obesity/complications MH - Obesity, Abdominal/complications MH - ROC Curve MH - *Renal Insufficiency, Chronic/complications/diagnosis MH - Waist Circumference PMC - PMC9002364 OTO - NOTNLM OT - chronic kidney disease OT - lipid accumulation product OT - metabolic syndrome OT - type 2 diabetes mellitus OT - visceral adiposity index OT - visceral fat area COIS- The authors declare no conflict of interest. EDAT- 2022/04/13 06:00 MHDA- 2022/04/14 06:00 PMCR- 2022/03/23 CRDT- 2022/04/12 01:02 PHST- 2022/01/28 00:00 [received] PHST- 2022/03/16 00:00 [revised] PHST- 2022/03/20 00:00 [accepted] PHST- 2022/04/12 01:02 [entrez] PHST- 2022/04/13 06:00 [pubmed] PHST- 2022/04/14 06:00 [medline] PHST- 2022/03/23 00:00 [pmc-release] AID - nu14071334 [pii] AID - nutrients-14-01334 [pii] AID - 10.3390/nu14071334 [doi] PST - epublish SO - Nutrients. 2022 Mar 23;14(7):1334. doi: 10.3390/nu14071334.