PMID- 35406088
OWN - NLM
STAT- MEDLINE
DCOM- 20220413
LR  - 20240111
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 7
DP  - 2022 Apr 1
TI  - Consumption of Cashew (Anacardium occidentale L.) Nuts Counteracts Oxidative 
      Stress and Tissue Inflammation in Mild Hyperhomocysteinemia in Rats.
LID - 10.3390/nu14071474 [doi]
LID - 1474
AB  - Hyperhomocysteinemia (HHcy) is a methionine metabolism problem that causes a 
      variety of inflammatory illnesses. Oxidative stress is among the processes 
      thought to be involved in the pathophysiology of the damage produced by HHcy. 
      HHcy is likely to involve the dysfunction of several organs, such as the kidney, 
      liver, or gut, which are currently poorly understood. Nuts are regarded as an 
      important part of a balanced diet since they include protein, good fatty acids, 
      and critical nutrients. The aim of this work was to evaluate the 
      anti-inflammatory and antioxidant effects of cashew nuts in HHcy induced by oral 
      methionine administration for 30 days, and to examine the possible pathways 
      involved. In HHcy rats, cashew nuts (100 mg/kg orally, daily) were able to 
      counteract clinical biochemical changes, oxidative and nitrosative stress, 
      reduced antioxidant enzyme levels, lipid peroxidation, proinflammatory cytokine 
      release, histological tissue injuries, and apoptosis in the kidney, colon, and 
      liver, possibly by the modulation of the antioxidant nuclear factor erythroid 
      2-related factor 2 NRF-2 and inflammatory nuclear factor NF-kB pathways. Thus, 
      the results suggest that the consumption of cashew nuts may be beneficial for the 
      treatment of inflammatory conditions associated with HHcy.
FAU - D'Amico, Ramona
AU  - D'Amico R
AUID- ORCID: 0000-0003-0389-3871
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Via F. Stagno D'Alcontres 31, 98166 Messina, Italy.
FAU - Cordaro, Marika
AU  - Cordaro M
AUID- ORCID: 0000-0002-3980-0043
AD  - Department of Biomedical, Dental and Morphological and Functional Imaging, 
      University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
FAU - Fusco, Roberta
AU  - Fusco R
AUID- ORCID: 0000-0003-0223-1403
AD  - Department of Clinical and Experimental Medicine, University of Messina, 98125 
      Messina, Italy.
FAU - Peritore, Alessio Filippo
AU  - Peritore AF
AUID- ORCID: 0000-0001-8545-990X
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Via F. Stagno D'Alcontres 31, 98166 Messina, Italy.
FAU - Genovese, Tiziana
AU  - Genovese T
AUID- ORCID: 0000-0002-3335-7327
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Via F. Stagno D'Alcontres 31, 98166 Messina, Italy.
FAU - Gugliandolo, Enrico
AU  - Gugliandolo E
AUID- ORCID: 0000-0001-6840-3154
AD  - Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
FAU - Crupi, Rosalia
AU  - Crupi R
AUID- ORCID: 0000-0002-7629-3132
AD  - Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
FAU - Mandalari, Giuseppina
AU  - Mandalari G
AUID- ORCID: 0000-0001-5663-3702
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Via F. Stagno D'Alcontres 31, 98166 Messina, Italy.
FAU - Caccamo, Daniela
AU  - Caccamo D
AD  - Department of Biomedical, Dental and Morphological and Functional Imaging, 
      University of Messina, Via Consolare Valeria, 98125 Messina, Italy.
FAU - Cuzzocrea, Salvatore
AU  - Cuzzocrea S
AUID- ORCID: 0000-0001-6131-3690
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Via F. Stagno D'Alcontres 31, 98166 Messina, Italy.
AD  - Department of Pharmacological and Physiological Science, Saint Louis University 
      School of Medicine, 1402 South Grand Blvd, St. Louis, MO 63104, USA.
FAU - Di Paola, Rosanna
AU  - Di Paola R
AUID- ORCID: 0000-0001-6725-8581
AD  - Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
FAU - Siracusa, Rosalba
AU  - Siracusa R
AUID- ORCID: 0000-0001-7868-2505
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Via F. Stagno D'Alcontres 31, 98166 Messina, Italy.
FAU - Impellizzeri, Daniela
AU  - Impellizzeri D
AUID- ORCID: 0000-0001-9492-3161
AD  - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, 
      University of Messina, Via F. Stagno D'Alcontres 31, 98166 Messina, Italy.
LA  - eng
PT  - Journal Article
DEP - 20220401
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Antioxidants)
RN  - AE28F7PNPL (Methionine)
SB  - IM
EIN - Nutrients. 2023 Dec 30;16(1):. PMID: 38202007
MH  - *Anacardium
MH  - Animals
MH  - Antioxidants/metabolism
MH  - *Hyperhomocysteinemia/pathology
MH  - Inflammation
MH  - Methionine/metabolism
MH  - Nuts/metabolism
MH  - Oxidative Stress
MH  - Rats
PMC - PMC9002620
OTO - NOTNLM
OT  - NF-kappaB
OT  - NRF-2
OT  - cashew nut
OT  - hyperhomocysteinemia
OT  - oxidative stress
COIS- The authors declare no conflict of interest.
EDAT- 2022/04/13 06:00
MHDA- 2022/04/14 06:00
PMCR- 2022/04/01
CRDT- 2022/04/12 01:03
PHST- 2022/03/07 00:00 [received]
PHST- 2022/03/28 00:00 [revised]
PHST- 2022/03/30 00:00 [accepted]
PHST- 2022/04/12 01:03 [entrez]
PHST- 2022/04/13 06:00 [pubmed]
PHST- 2022/04/14 06:00 [medline]
PHST- 2022/04/01 00:00 [pmc-release]
AID - nu14071474 [pii]
AID - nutrients-14-01474 [pii]
AID - 10.3390/nu14071474 [doi]
PST - epublish
SO  - Nutrients. 2022 Apr 1;14(7):1474. doi: 10.3390/nu14071474.