PMID- 35406495
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230918
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 14
IP  - 7
DP  - 2022 Mar 28
TI  - Overview on Molecular Biomarkers for Laryngeal Cancer: Looking for New Answers to 
      an Old Problem.
LID - 10.3390/cancers14071716 [doi]
LID - 1716
AB  - Laryngeal squamous cell cancer (LSCC) accounts for almost 25-30% of all head and 
      neck squamous cell cancers and is clustered according to the affected districts, 
      as this determines distinct tendency to recur and metastasize. A major role for 
      numerous genetic alterations in driving the onset and progression of this 
      neoplasm is emerging. However, major efforts are still required for the 
      identification of molecular markers useful for both early diagnosis and 
      prognostic definition of LSCC that is still characterized by significant 
      morbidity and mortality. Non-coding RNAs appear the most promising as they 
      circulate in all the biological fluids allowing liquid biopsy determination, as 
      well as due to their quick and characteristic modulation useful for non-invasive 
      detection and monitoring of cancer. Other critical aspects are related to recent 
      progress in circulating tumor cells and DNA detection, in metastatic status and 
      chemo-refractoriness prediction, and in the functional interaction of LSCC with 
      chronic inflammation and innate immunity. We review all these aspects taking into 
      account the progress of the technologies in the field of next generation 
      sequencing.
FAU - Falco, Michela
AU  - Falco M
AD  - Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 
      80138 Naples, Italy.
FAU - Tammaro, Chiara
AU  - Tammaro C
AD  - Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 
      80138 Naples, Italy.
FAU - Takeuchi, Takashi
AU  - Takeuchi T
AD  - Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 
      80138 Naples, Italy.
AD  - Molecular Diagnostics Division, Wakunaga Pharmaceutical Co., Ltd., Hiroshima 
      739-1195, Japan.
FAU - Cossu, Alessia Maria
AU  - Cossu AM
AUID- ORCID: 0000-0003-2646-1254
AD  - Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 
      80138 Naples, Italy.
AD  - Laboratory of Molecular and Precision Oncology, Biogem Scarl, Institute of 
      Genetic Research, 83031 Ariano Irpino, Italy.
FAU - Scafuro, Giuseppe
AU  - Scafuro G
AD  - Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 
      80138 Naples, Italy.
FAU - Zappavigna, Silvia
AU  - Zappavigna S
AUID- ORCID: 0000-0003-4787-3776
AD  - Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 
      80138 Naples, Italy.
FAU - Itro, Annalisa
AU  - Itro A
AUID- ORCID: 0000-0002-0226-7521
AD  - Department of Advanced Medical and Surgical Sciences, University of Campania 
      "Luigi Vanvitelli", 80138 Naples, Italy.
FAU - Addeo, Raffaele
AU  - Addeo R
AUID- ORCID: 0000-0001-9197-8060
AD  - Oncology Operative Unit, Hospital of Frattamaggiore, ASLNA-2NORD, 80020 Naples, 
      Italy.
FAU - Scrima, Marianna
AU  - Scrima M
AUID- ORCID: 0000-0003-4636-7695
AD  - Laboratory of Molecular and Precision Oncology, Biogem Scarl, Institute of 
      Genetic Research, 83031 Ariano Irpino, Italy.
FAU - Lombardi, Angela
AU  - Lombardi A
AD  - Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 
      80138 Naples, Italy.
FAU - Ricciardiello, Filippo
AU  - Ricciardiello F
AD  - Division of Otorhinolaryngology, "A. Cardarelli" Hospital, 80131 Naples, Italy.
FAU - Irace, Carlo
AU  - Irace C
AUID- ORCID: 0000-0002-5172-4573
AD  - Department of Pharmacy, School of Medicine and Surgery, University of Naples 
      "Federico II", 80131 Naples, Italy.
FAU - Caraglia, Michele
AU  - Caraglia M
AUID- ORCID: 0000-0003-2408-6091
AD  - Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 
      80138 Naples, Italy.
AD  - Laboratory of Molecular and Precision Oncology, Biogem Scarl, Institute of 
      Genetic Research, 83031 Ariano Irpino, Italy.
FAU - Misso, Gabriella
AU  - Misso G
AUID- ORCID: 0000-0002-7787-2531
AD  - Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 
      80138 Naples, Italy.
LA  - eng
GR  - SENSORMIRCIRCOLAR/POR Campania FESR 2014/2020/
GR  - Linea 5/11/FSN 2014-2015-2016/
PT  - Journal Article
PT  - Review
DEP - 20220328
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC8997012
OTO - NOTNLM
OT  - CTC
OT  - LSCC (laryngeal squamous cell carcinoma)
OT  - TME (tumor microenvironment)
OT  - biomarkers
OT  - ctDNA
OT  - epigenetic modifications
OT  - inflammatory markers
OT  - lncRNA
OT  - miRNA
COIS- The authors declare no conflict of interest between the company and the other 
      affiliations. Takeuchi did his Ph.D. in Biochemical and Biotechnological Sciences 
      at the University of Campania "Luigi Vanvitelli" in the Department of Precision 
      Medicine, while remaining an employee of Wakunaga Company.
EDAT- 2022/04/13 06:00
MHDA- 2022/04/13 06:01
PMCR- 2022/03/28
CRDT- 2022/04/12 01:04
PHST- 2022/01/31 00:00 [received]
PHST- 2022/03/01 00:00 [revised]
PHST- 2022/03/24 00:00 [accepted]
PHST- 2022/04/12 01:04 [entrez]
PHST- 2022/04/13 06:00 [pubmed]
PHST- 2022/04/13 06:01 [medline]
PHST- 2022/03/28 00:00 [pmc-release]
AID - cancers14071716 [pii]
AID - cancers-14-01716 [pii]
AID - 10.3390/cancers14071716 [doi]
PST - epublish
SO  - Cancers (Basel). 2022 Mar 28;14(7):1716. doi: 10.3390/cancers14071716.