PMID- 35407061
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2304-8158 (Print)
IS  - 2304-8158 (Electronic)
IS  - 2304-8158 (Linking)
VI  - 11
IP  - 7
DP  - 2022 Mar 27
TI  - Anti-Diabetic Effects of Ethanol Extract from Sanghuangporous vaninii in 
      High-Fat/Sucrose Diet and Streptozotocin-Induced Diabetic Mice by Modulating Gut 
      Microbiota.
LID - 10.3390/foods11070974 [doi]
LID - 974
AB  - Type 2 diabetes mellitus (T2DM) may lead to abnormally elevated blood glucose, 
      lipid metabolism disorder, and low-grade inflammation. Besides, the development 
      of T2DM is always accompanied by gut microbiota dysbiosis and metabolic 
      dysfunction. In this study, the T2DM mice model was established by feeding a 
      high-fat/sucrose diet combined with injecting a low dose of streptozotocin. 
      Additionally, the effects of oral administration of ethanol extract from 
      Sanghuangporous vaninii (SVE) on T2DM and its complications (including 
      hypoglycemia, hyperlipidemia, inflammation, and gut microbiota dysbiosis) were 
      investigated. The results showed SVE could improve body weight, glycolipid 
      metabolism, and inflammation-related parameters. Besides, SVE intervention 
      effectively ameliorated the diabetes-induced pancreas and jejunum injury. 
      Furthermore, SVE intervention significantly increased the relative abundances of 
      Akkermansia, Dubosiella, Bacteroides, and Parabacteroides, and decreased the 
      levels of Lactobacillus, Flavonifractor, Odoribacter, and Desulfovibrio compared 
      to the model group (LDA > 3.0, p < 0.05). Metabolic function prediction of the 
      intestinal microbiota by PICRUSt revealed that glycerolipid metabolism, insulin 
      signaling pathway, PI3K-Akt signaling pathway, and fatty acid degradation were 
      enriched in the diabetic mice treated with SVE. Moreover, the integrative 
      analysis indicated that the key intestinal microbial phylotypes in response to 
      SVE intervention were strongly correlated with glucose and lipid 
      metabolism-associated biochemical parameters. These findings demonstrated that 
      SVE has the potential to alleviate T2DM and its complications by modulating the 
      gut microbiota imbalance.
FAU - Huang, Zi-Rui
AU  - Huang ZR
AUID- ORCID: 0000-0002-0822-352X
AD  - College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 
      350002, China.
AD  - National Engineering Research Center of JUNCAO Technology, Fuzhou 350002, China.
FAU - Zhao, Li-Yuan
AU  - Zhao LY
AD  - College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 
      350002, China.
FAU - Zhu, Fu-Rong
AU  - Zhu FR
AD  - National Engineering Research Center of JUNCAO Technology, Fuzhou 350002, China.
FAU - Liu, Yun
AU  - Liu Y
AD  - College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 
      350002, China.
FAU - Xiao, Jian-Yong
AU  - Xiao JY
AD  - College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 
      350002, China.
FAU - Chen, Zhi-Chao
AU  - Chen ZC
AD  - College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 
      350002, China.
FAU - Lv, Xu-Cong
AU  - Lv XC
AUID- ORCID: 0000-0002-0594-4284
AD  - Institute of Food Science and Technology, College of Biological Science and 
      Technology, Fuzhou University, Fuzhou 350108, China.
FAU - Huang, Ying
AU  - Huang Y
AD  - College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 
      350002, China.
FAU - Liu, Bin
AU  - Liu B
AD  - National Engineering Research Center of JUNCAO Technology, Fuzhou 350002, China.
LA  - eng
GR  - 2021NZ0101/Fujian Province Science and Technology Major Special Projects/
GR  - XKJC-712021030/Interdisciplinary integration to promote the high-quality 
      development projects of Juncao science and industry/
GR  - 2014NZ2002-1/Fujian Province Science and Technology Major Special Projects/
PT  - Journal Article
DEP - 20220327
PL  - Switzerland
TA  - Foods
JT  - Foods (Basel, Switzerland)
JID - 101670569
PMC - PMC8997417
OTO - NOTNLM
OT  - Sanghuangporous vaninii
OT  - anti-diabetic effect
OT  - gut microbiota
OT  - hyperglycemia
OT  - hyperlipidemia
COIS- The authors declare no conflict of interest.
EDAT- 2022/04/13 06:00
MHDA- 2022/04/13 06:01
PMCR- 2022/03/27
CRDT- 2022/04/12 01:05
PHST- 2022/02/16 00:00 [received]
PHST- 2022/03/21 00:00 [revised]
PHST- 2022/03/24 00:00 [accepted]
PHST- 2022/04/12 01:05 [entrez]
PHST- 2022/04/13 06:00 [pubmed]
PHST- 2022/04/13 06:01 [medline]
PHST- 2022/03/27 00:00 [pmc-release]
AID - foods11070974 [pii]
AID - foods-11-00974 [pii]
AID - 10.3390/foods11070974 [doi]
PST - epublish
SO  - Foods. 2022 Mar 27;11(7):974. doi: 10.3390/foods11070974.