PMID- 35408641
OWN - NLM
STAT- MEDLINE
DCOM- 20220413
LR  - 20230308
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 27
IP  - 7
DP  - 2022 Mar 30
TI  - Comparison of Dechlorane Plus Concentrations in Sequential Blood Samples of 
      Pregnant Women in Taizhou, China.
LID - 10.3390/molecules27072242 [doi]
LID - 2242
AB  - To develop an appropriate sampling strategy to assess the intrauterine exposure 
      to dechlorane plus (DP), we investigated DP levels in sequential maternal blood 
      samples collected in three trimesters of pregnancy, respectively, from women 
      living in Taizhou. The median concentration of DPs (sum of syn-DP and anti-DP) in 
      all samples was 30.5 pg g-1 wet-weight and 5.01 ng g-1 lipid-adjusted weight, 
      respectively. The trimester-related DP concentrations were consistently strongly 
      correlated (p < 0.01), indicating that a single measurement of DP levels could 
      represent intrauterine exposure without sampling from the same female repeatedly; 
      however, the wet-weight levels significantly increased across trimesters (p < 
      0.05), while the lipid-adjusted levels did not significantly vary. Notably, 
      whether lipid-adjusted weight or wet-weight levels, the variation extent of DP 
      across trimesters was found to be less than 41%, and those for other persistent 
      organic pollutants (POPs) reported in the literature were also limited to 100%. 
      The limitation in variation extents indicated that, regardless of the time of 
      blood collection during pregnancy and how the levels were expressed, a single 
      measurement could be extended to screen for exposure risk if necessary. Our study 
      provides different strategies for sampling the maternal blood to serve the 
      requirement for assessment of in utero exposure to DP.
FAU - Li, Ji-Fang-Tong
AU  - Li JF
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing 
      Road, Haidian District, Beijing 100085, China.
AD  - University of Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, 
      Beijing 100049, China.
FAU - Li, Xing-Hong
AU  - Li XH
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing 
      Road, Haidian District, Beijing 100085, China.
AD  - University of Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, 
      Beijing 100049, China.
FAU - Wan, Yao-Yuan
AU  - Wan YY
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing 
      Road, Haidian District, Beijing 100085, China.
AD  - University of Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, 
      Beijing 100049, China.
FAU - Li, Yuan-Yuan
AU  - Li YY
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing 
      Road, Haidian District, Beijing 100085, China.
AD  - University of Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, 
      Beijing 100049, China.
FAU - Qin, Zhan-Fen
AU  - Qin ZF
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing 
      Road, Haidian District, Beijing 100085, China.
AD  - University of Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, 
      Beijing 100049, China.
LA  - eng
GR  - 21777185/National Natural Science Foundation of China/
GR  - 21976204/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20220330
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Flame Retardants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Lipids)
RN  - 0 (Polycyclic Compounds)
RN  - 0 (dechlorane plus)
SB  - IM
MH  - China
MH  - Environmental Monitoring
MH  - Female
MH  - *Flame Retardants/analysis
MH  - Humans
MH  - *Hydrocarbons, Chlorinated/analysis
MH  - Lipids
MH  - *Polycyclic Compounds
MH  - Pregnancy
MH  - Pregnant Women
PMC - PMC9000586
OTO - NOTNLM
OT  - correlation
OT  - dechlorane plus
OT  - maternal blood
OT  - sequential samples
OT  - variation
COIS- The authors declare no conflict of interest.
EDAT- 2022/04/13 06:00
MHDA- 2022/04/14 06:00
PMCR- 2022/03/30
CRDT- 2022/04/12 01:11
PHST- 2022/02/06 00:00 [received]
PHST- 2022/03/28 00:00 [revised]
PHST- 2022/03/29 00:00 [accepted]
PHST- 2022/04/12 01:11 [entrez]
PHST- 2022/04/13 06:00 [pubmed]
PHST- 2022/04/14 06:00 [medline]
PHST- 2022/03/30 00:00 [pmc-release]
AID - molecules27072242 [pii]
AID - molecules-27-02242 [pii]
AID - 10.3390/molecules27072242 [doi]
PST - epublish
SO  - Molecules. 2022 Mar 30;27(7):2242. doi: 10.3390/molecules27072242.