PMID- 35409960
OWN - NLM
STAT- MEDLINE
DCOM- 20220413
LR  - 20220509
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 19
IP  - 7
DP  - 2022 Apr 2
TI  - Myocarditis in Athletes Recovering from COVID-19: A Systematic Review and 
      Meta-Analysis.
LID - 10.3390/ijerph19074279 [doi]
LID - 4279
AB  - BACKGROUND: To assess the event rates of myocarditis detected by Cardiac Magnetic 
      Resonance (CMR) in athletes who recovered from COVID-19. METHODS: A systematic 
      literature search was performed to identify studies reporting abnormal CMR 
      findings in athletes who recovered from COVID-19. Secondary analyses were 
      performed considering increased serum high sensitivity troponin (hs-Tn) levels 
      and electrocardiographic (ECG) and echocardiographic (ECHO) abnormalities. 
      RESULTS: In total, 7988 athletes from 15 studies were included in the analysis. 
      The pooled event rate of myocarditis was 1% (CI 1-2%), reaching 4% in the 
      sub-group analysis. In addition, heterogeneity was observed (I2 43.8%). The 
      pooled event rates of elevated serum hs-Tn levels, abnormal ECG and ECHO findings 
      were 2% (CI 1-5%), 3% (CI 1-10%) and 2% (CI 1-6%), respectively. ECG, ECHO and 
      serum hs-Tn level abnormalities did not show any correlation with myocarditis. 
      CONCLUSIONS: The prevalence of COVID-19-related myocarditis in the athletic 
      population ranges from 1 to 4%. Even if the event rate is quite low, current 
      screening protocols are helpful tools for a safe return to play to properly 
      address CMR studies. TRIAL REGISTRATION: the study protocol was registered in the 
      PROSPERO database (registration number: CRD42022300819).
FAU - Modica, Gloria
AU  - Modica G
AD  - Sports Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 
      Catholic University, 00168 Rome, Italy.
FAU - Bianco, Massimiliano
AU  - Bianco M
AUID- ORCID: 0000-0002-0587-5899
AD  - Sports Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 
      Catholic University, 00168 Rome, Italy.
FAU - Sollazzo, Fabrizio
AU  - Sollazzo F
AD  - Sports Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 
      Catholic University, 00168 Rome, Italy.
FAU - Di Murro, Emanuela
AU  - Di Murro E
AD  - Sports Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 
      Catholic University, 00168 Rome, Italy.
FAU - Monti, Riccardo
AU  - Monti R
AD  - Sports Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 
      Catholic University, 00168 Rome, Italy.
FAU - Cammarano, Michela
AU  - Cammarano M
AUID- ORCID: 0000-0001-6024-3459
AD  - Sports Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 
      Catholic University, 00168 Rome, Italy.
FAU - Morra, Lorenzo
AU  - Morra L
AD  - Sports Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 
      Catholic University, 00168 Rome, Italy.
FAU - Nifosi, Francesco Maria
AU  - Nifosi FM
AD  - Sports Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 
      Catholic University, 00168 Rome, Italy.
FAU - Gervasi, Salvatore Francesco
AU  - Gervasi SF
AD  - Sports Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 
      Catholic University, 00168 Rome, Italy.
FAU - Manes Gravina, Ester
AU  - Manes Gravina E
AD  - Department of Geriatrics, Neurosciences, Orthopaedics and Head and Neck, 
      Universita Cattolica del Sacro Cuore-Fondazione Policlinico 'Agostino Gemelli' 
      IRCCS, 00168 Rome, Italy.
FAU - Zeppilli, Paolo
AU  - Zeppilli P
AD  - Sports Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 
      Catholic University, 00168 Rome, Italy.
FAU - Palmieri, Vincenzo
AU  - Palmieri V
AD  - Sports Medicine Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 
      Catholic University, 00168 Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20220402
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - Athletes
MH  - *COVID-19/epidemiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *Myocarditis/diagnostic imaging/epidemiology
MH  - SARS-CoV-2
PMC - PMC8998516
OTO - NOTNLM
OT  - COVID-19
OT  - athletes
OT  - cardiac magnetic resonance
OT  - myocarditis
OT  - physical activity
COIS- The authors declare no conflict of interest.
EDAT- 2022/04/13 06:00
MHDA- 2022/04/14 06:00
PMCR- 2022/04/02
CRDT- 2022/04/12 01:15
PHST- 2022/02/17 00:00 [received]
PHST- 2022/03/25 00:00 [revised]
PHST- 2022/04/01 00:00 [accepted]
PHST- 2022/04/12 01:15 [entrez]
PHST- 2022/04/13 06:00 [pubmed]
PHST- 2022/04/14 06:00 [medline]
PHST- 2022/04/02 00:00 [pmc-release]
AID - ijerph19074279 [pii]
AID - ijerph-19-04279 [pii]
AID - 10.3390/ijerph19074279 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2022 Apr 2;19(7):4279. doi: 
      10.3390/ijerph19074279.