PMID- 35411164 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220413 IS - 1178-7007 (Print) IS - 1178-7007 (Electronic) IS - 1178-7007 (Linking) VI - 15 DP - 2022 TI - Free Triiodothyronine Levels are Related to Executive Function and Scene Memory in Type 2 Diabetes Mellitus Patients Without Diagnosed Thyroid Diseases. PG - 1041-1050 LID - 10.2147/DMSO.S355656 [doi] AB - PURPOSE: We aim to determine the role of free triiodothyronine (FT3), the main active ingredient of thyroid hormones (THs), in type 2 diabetes mellitus (T2DM) patients with mild cognitive impairment (MCI). PATIENTS AND METHODS: A total of 255 T2DM patients without diagnosed thyroid diseases were recruited and divided into MCI group and healthy cognition group. Neuropsychological functions were observed by multidimensional cognitive function scales in including MoCA, Digit Span Test (DST), Verbal Fluency Test (VFT), Clock drawing test (CDT), Trail Making Test (TMT) A and B, Instantaneously Recalled Auditory Verbal Learning Test (AVLT-IR), Delayed Recalled Auditory Verbal Learning Test (AVLT-DR) and Logical Memory Test (LMT). Correlation and logistic regression analyses were performed to explore the association between FT3 and diabetic cognitive dysfunction. RESULTS: Compared with 147 normal cognition patients, 108 MCI patients exhibited lower FT3 and higher HOMA-IR. FT3 level was not only positively correlated with MoCA scores, but DST, VFT and LMT, while negatively associated with TMTB. Furthermore, there is a negative association between FT3 and HOMA-IR. Logistic regression showed that decreased FT3 is a risk factor of MCI in T2DM patients. Although FT3 is not the risk factor of MCI after homeostasis model assessment of insulin resistance (HOMA-IR) was entered as an independent variable, lower FT3 is associated with VFT and LMT adjusted by age, education, BMI, DM duration, HBP duration, smoking, HbA1c and HOMA-IR. CONCLUSION: Lower FT3 levels may involve in MCI, especially for executive function and scene memory in T2DM patients without diagnosed thyroid diseases. CI - (c) 2022 Zhang et al. FAU - Zhang, Haoqiang AU - Zhang H AUID- ORCID: 0000-0001-6937-4252 AD - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, Nanjing, People's Republic of China. AD - School of Medicine, Southeast University, Nanjing, People's Republic of China. AD - Department of Endocrinology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, People's Republic of China. FAU - Yang, Shufang AU - Yang S AD - School of Medicine, Southeast University, Nanjing, People's Republic of China. AD - Department of Endocrinology, Taizhou People's Hospital, Taizhou, People's Republic of China. FAU - Zhu, Wenwen AU - Zhu W AD - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, Nanjing, People's Republic of China. AD - School of Medicine, Southeast University, Nanjing, People's Republic of China. FAU - Niu, Tong AU - Niu T AD - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, Nanjing, People's Republic of China. AD - School of Medicine, Southeast University, Nanjing, People's Republic of China. FAU - Wang, Zheng AU - Wang Z AD - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, Nanjing, People's Republic of China. AD - School of Medicine, Southeast University, Nanjing, People's Republic of China. FAU - An, Ke AU - An K AD - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, Nanjing, People's Republic of China. AD - School of Medicine, Southeast University, Nanjing, People's Republic of China. FAU - Xie, Zuoling AU - Xie Z AD - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, Nanjing, People's Republic of China. AD - School of Medicine, Southeast University, Nanjing, People's Republic of China. FAU - Wang, Pin AU - Wang P AD - School of Medicine, Southeast University, Nanjing, People's Republic of China. FAU - Huang, Xi AU - Huang X AD - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, Nanjing, People's Republic of China. AD - School of Medicine, Southeast University, Nanjing, People's Republic of China. FAU - Wang, Chenchen AU - Wang C AD - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, Nanjing, People's Republic of China. AD - School of Medicine, Southeast University, Nanjing, People's Republic of China. FAU - Shangguan, Haiyan AU - Shangguan H AD - School of Medicine, Southeast University, Nanjing, People's Republic of China. FAU - Yuan, Yang AU - Yuan Y AD - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, Nanjing, People's Republic of China. FAU - Wang, Shaohua AU - Wang S AD - Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, Nanjing, People's Republic of China. LA - eng PT - Journal Article DEP - 20220405 PL - New Zealand TA - Diabetes Metab Syndr Obes JT - Diabetes, metabolic syndrome and obesity : targets and therapy JID - 101515585 PMC - PMC8994555 OTO - NOTNLM OT - free triiodothyronine OT - insulin resistance OT - mild cognitive impairment OT - type 2 diabetes mellitus COIS- The authors report no conflicts of interest in this work. EDAT- 2022/04/13 06:00 MHDA- 2022/04/13 06:01 PMCR- 2022/04/05 CRDT- 2022/04/12 05:30 PHST- 2021/12/24 00:00 [received] PHST- 2022/03/15 00:00 [accepted] PHST- 2022/04/12 05:30 [entrez] PHST- 2022/04/13 06:00 [pubmed] PHST- 2022/04/13 06:01 [medline] PHST- 2022/04/05 00:00 [pmc-release] AID - 355656 [pii] AID - 10.2147/DMSO.S355656 [doi] PST - epublish SO - Diabetes Metab Syndr Obes. 2022 Apr 5;15:1041-1050. doi: 10.2147/DMSO.S355656. eCollection 2022.