PMID- 35411517
OWN - NLM
STAT- MEDLINE
DCOM- 20220913
LR  - 20220913
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 29
IP  - 41
DP  - 2022 Sep
TI  - Environmental thallium exposure and the risk of early embryonic arrest among 
      women undergoing in vitro fertilization: thallium exposure and polymorphisms of 
      mtDNA gene interaction and potential cause exploring.
PG  - 62648-62661
LID - 10.1007/s11356-022-19978-2 [doi]
AB  - Early embryonic arrest (EEA) leads to cancelation of fresh cycles among infertile 
      women undergoing in vitro fertilization (IVF), bringing a great challenge for 
      IVF. Whether exposure to thallium (Tl) is associated with an increased risk of 
      EEA, especially its interaction with polymorphisms of mitochondria DNA (mtDNA) 
      gene, is worthy of study. A case-control design was performed, including 74 EEA 
      cases with 123 IVF cycles and 157 age and BMI-matched controls with 180 IVF 
      cycles. Levels of Tl and other toxic metals (lead (Pb), (mercury) Hg, and 
      (arsenci) As) were assessed by measuring them in blood samples collected on the 
      day of oocyte retrieval; PCR amplification and sequencing were performed to 
      screen the polymorphic sites of mtDNA gene in D-loop region. Bayesian kernel 
      machine regression (BKMR) was used to confirm that Tl played a leading role in 
      the situation of combined exposure; generalized estimating equation (GEE) models 
      were used to evaluate the associations of Tl concentrations, polymorphisms of 
      mtDNA gene, and their interactions with the risk of EEA. The impact of Tl 
      exposure or polymorphisms of mtDNA gene on the oogenesis and embryonic 
      development was also evaluated. BKMR analysis revealed that PIP (posterior 
      inclusion probability) value of T1 was 0.9096, indicating that it played a 
      leading role in the situation of combined exposure. Compared to the first 
      quartile of Tl, the adjusted ORs (95% CIs) of EEA risk were 0.66 (0.26, 1.70), 
      1.18 (0.52, 2.64), and 4.53 (2.11, 9.69) for the second, third, and fourth 
      quartile, respectively (p trend < 0.001). Compared to the wild type of mtDNA 
      16,519 gene (T 16,519 T), the adjusted OR (95% CI) of EEA risk for the variant 
      type (T 16,519 C) was 3.11 (1.70, 5.72), and the variant types of the other sites 
      with a minor allele frequency > 10% were not significantly related with the risk 
      of EEA after FDR (False Discovery Rate) correction. With respect to interaction, 
      compared to women at low Tl exposure level & wild type of mtDNA 16,519 gene 
      group, the adjusted OR (95% CI) of EEA risk for women at high Tl exposure level & 
      variant type of mtDNA 16,519 gene group was 9.28 (3.33, 25.81). Additionally, Tl 
      exposure and polymorphisms of mtDNA 16,519 gene are inversely associated with the 
      outcomes of oogenesis and embryonic development significantly. Our study 
      indicated that high Tl exposure level was associated with the increased risk of 
      EEA and Tl played a leading role in the situation of combined exposure; the 
      strength of association was much higher when Tl exposure interacted with 
      polymorphism of 16,519 mtDNA gene. These relationships might originate from the 
      impact of Tl exposure or polymorphism of 16,519 mtDNA gene on the oogenesis and 
      early embryonic development in vitro. Infertile women should keep high vigilant 
      against Tl exposure especially those with variant type of mtDNA 16,519 gene.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Liang, Chunmei
AU  - Liang C
AUID- ORCID: 0000-0003-1639-7543
AD  - Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui 
      Medical University, No 218 Jixi Road, Hefei, 230022, Anhui, China. 
      liang_chun_mei@126.com.
AD  - NHC Key Laboratory of Study On Abnormal Gametes and Reproductive Tract (Anhui 
      Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China. 
      liang_chun_mei@126.com.
AD  - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), 
      Ministry of Education of the People's Republic of China, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China. liang_chun_mei@126.com.
AD  - Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan 
      Road, Hefei, 230032, Anhui, China. liang_chun_mei@126.com.
AD  - Biopreservation and Artificial Organs, Anhui Provincial Engineering Research 
      Center, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, 
      China. liang_chun_mei@126.com.
AD  - Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, 
      230032, Anhui, China. liang_chun_mei@126.com.
FAU - Luo, Guiying
AU  - Luo G
AD  - Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui 
      Medical University, No 218 Jixi Road, Hefei, 230022, Anhui, China.
AD  - NHC Key Laboratory of Study On Abnormal Gametes and Reproductive Tract (Anhui 
      Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.
AD  - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), 
      Ministry of Education of the People's Republic of China, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China.
AD  - Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan 
      Road, Hefei, 230032, Anhui, China.
AD  - Biopreservation and Artificial Organs, Anhui Provincial Engineering Research 
      Center, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, 
      China.
AD  - Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Cao, Yu
AU  - Cao Y
AD  - Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui 
      Medical University, No 218 Jixi Road, Hefei, 230022, Anhui, China.
AD  - NHC Key Laboratory of Study On Abnormal Gametes and Reproductive Tract (Anhui 
      Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.
AD  - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), 
      Ministry of Education of the People's Republic of China, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China.
AD  - Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan 
      Road, Hefei, 230032, Anhui, China.
AD  - Biopreservation and Artificial Organs, Anhui Provincial Engineering Research 
      Center, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, 
      China.
AD  - Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Li, Danyang
AU  - Li D
AD  - Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui 
      Medical University, No 218 Jixi Road, Hefei, 230022, Anhui, China.
AD  - NHC Key Laboratory of Study On Abnormal Gametes and Reproductive Tract (Anhui 
      Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.
AD  - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), 
      Ministry of Education of the People's Republic of China, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China.
AD  - Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan 
      Road, Hefei, 230032, Anhui, China.
AD  - Biopreservation and Artificial Organs, Anhui Provincial Engineering Research 
      Center, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, 
      China.
AD  - Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Shen, Lingchao
AU  - Shen L
AD  - Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui 
      Medical University, No 218 Jixi Road, Hefei, 230022, Anhui, China.
AD  - NHC Key Laboratory of Study On Abnormal Gametes and Reproductive Tract (Anhui 
      Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.
AD  - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), 
      Ministry of Education of the People's Republic of China, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China.
AD  - Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan 
      Road, Hefei, 230032, Anhui, China.
AD  - Biopreservation and Artificial Organs, Anhui Provincial Engineering Research 
      Center, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, 
      China.
AD  - Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Zhang, Zhikang
AU  - Zhang Z
AD  - Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui 
      Medical University, No 218 Jixi Road, Hefei, 230022, Anhui, China.
AD  - NHC Key Laboratory of Study On Abnormal Gametes and Reproductive Tract (Anhui 
      Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.
AD  - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), 
      Ministry of Education of the People's Republic of China, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China.
AD  - Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan 
      Road, Hefei, 230032, Anhui, China.
AD  - Biopreservation and Artificial Organs, Anhui Provincial Engineering Research 
      Center, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, 
      China.
AD  - Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Jiang, Tingting
AU  - Jiang T
AD  - School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Zong, Kai
AU  - Zong K
AD  - Technical Center of Hefei Customs District, No 329 Tunxi Road, Hefei, 230022, 
      Anhui, China.
FAU - Liang, Dan
AU  - Liang D
AD  - Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui 
      Medical University, No 218 Jixi Road, Hefei, 230022, Anhui, China.
AD  - NHC Key Laboratory of Study On Abnormal Gametes and Reproductive Tract (Anhui 
      Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.
AD  - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), 
      Ministry of Education of the People's Republic of China, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China.
AD  - Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan 
      Road, Hefei, 230032, Anhui, China.
AD  - Biopreservation and Artificial Organs, Anhui Provincial Engineering Research 
      Center, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, 
      China.
AD  - Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Zou, Weiwei
AU  - Zou W
AD  - Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui 
      Medical University, No 218 Jixi Road, Hefei, 230022, Anhui, China.
AD  - NHC Key Laboratory of Study On Abnormal Gametes and Reproductive Tract (Anhui 
      Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.
AD  - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), 
      Ministry of Education of the People's Republic of China, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China.
AD  - Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan 
      Road, Hefei, 230032, Anhui, China.
AD  - Biopreservation and Artificial Organs, Anhui Provincial Engineering Research 
      Center, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, 
      China.
AD  - Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Xu, Xiaofeng
AU  - Xu X
AD  - Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui 
      Medical University, No 218 Jixi Road, Hefei, 230022, Anhui, China.
AD  - NHC Key Laboratory of Study On Abnormal Gametes and Reproductive Tract (Anhui 
      Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.
AD  - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), 
      Ministry of Education of the People's Republic of China, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China.
AD  - Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan 
      Road, Hefei, 230032, Anhui, China.
AD  - Biopreservation and Artificial Organs, Anhui Provincial Engineering Research 
      Center, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, 
      China.
AD  - Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Liu, Yajing
AU  - Liu Y
AD  - Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui 
      Medical University, No 218 Jixi Road, Hefei, 230022, Anhui, China.
AD  - NHC Key Laboratory of Study On Abnormal Gametes and Reproductive Tract (Anhui 
      Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.
AD  - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), 
      Ministry of Education of the People's Republic of China, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China.
AD  - Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan 
      Road, Hefei, 230032, Anhui, China.
AD  - Biopreservation and Artificial Organs, Anhui Provincial Engineering Research 
      Center, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, 
      China.
AD  - Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Ji, Dongmei
AU  - Ji D
AD  - Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui 
      Medical University, No 218 Jixi Road, Hefei, 230022, Anhui, China.
AD  - NHC Key Laboratory of Study On Abnormal Gametes and Reproductive Tract (Anhui 
      Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.
AD  - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), 
      Ministry of Education of the People's Republic of China, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China.
AD  - Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan 
      Road, Hefei, 230032, Anhui, China.
AD  - Biopreservation and Artificial Organs, Anhui Provincial Engineering Research 
      Center, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, 
      China.
AD  - Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
FAU - Cao, Yunxia
AU  - Cao Y
AD  - Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui 
      Medical University, No 218 Jixi Road, Hefei, 230022, Anhui, China.
AD  - NHC Key Laboratory of Study On Abnormal Gametes and Reproductive Tract (Anhui 
      Medical University), No 81 Meishan Road, Hefei, 230032, Anhui, China.
AD  - Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), 
      Ministry of Education of the People's Republic of China, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China.
AD  - Anhui Province Key Laboratory of Reproductive Health and Genetics, No 81 Meishan 
      Road, Hefei, 230032, Anhui, China.
AD  - Biopreservation and Artificial Organs, Anhui Provincial Engineering Research 
      Center, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, 
      China.
AD  - Anhui Provincial Institute of Translational Medicine, No 81 Meishan Road, Hefei, 
      230032, Anhui, China.
LA  - eng
GR  - NSFC-U20A20350/National Natural Science Foundation of China/
GR  - NSFC-81871216/National Natural Science Foundation of China/
GR  - NSFC-81971455/National Natural Science Foundation of China/
GR  - NSFC-82173532/National Natural Science Foundation of China/
GR  - NSFC-81601345/National Natural Science Foundation of China/
GR  - 2021YFC2700600/Key Technologies Research and Development Program/
GR  - KJ2020A0203/University Natural Science Research Project of Anhui Province/
GR  - gxyq2021173/Excellent Young Talents Fund Program of Higher Education Institutions 
      of Anhui Province/
GR  - 2021M700181/Postdoctoral Research Foundation of China/
PT  - Journal Article
DEP - 20220411
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (DNA, Mitochondrial)
RN  - AD84R52XLF (Thallium)
SB  - IM
MH  - Bayes Theorem
MH  - DNA, Mitochondrial
MH  - Female
MH  - Fertilization in Vitro
MH  - Humans
MH  - *Infertility, Female
MH  - Mitochondria
MH  - Pregnancy
MH  - *Thallium/toxicity
OTO - NOTNLM
OT  - Early embryonic arrest
OT  - Exposure
OT  - Interaction
OT  - Mitochondrion
OT  - Thallium
EDAT- 2022/04/13 06:00
MHDA- 2022/09/14 06:00
CRDT- 2022/04/12 05:32
PHST- 2021/12/06 00:00 [received]
PHST- 2022/03/25 00:00 [accepted]
PHST- 2022/04/13 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
PHST- 2022/04/12 05:32 [entrez]
AID - 10.1007/s11356-022-19978-2 [pii]
AID - 10.1007/s11356-022-19978-2 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2022 Sep;29(41):62648-62661. doi: 
      10.1007/s11356-022-19978-2. Epub 2022 Apr 11.