PMID- 35415238
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 2391-5412 (Electronic)
IS  - 2391-5412 (Linking)
VI  - 17
IP  - 1
DP  - 2022
TI  - Intravenous infusion of the exosomes derived from human umbilical cord 
      mesenchymal stem cells enhance neurological recovery after traumatic brain injury 
      via suppressing the NF-kappaB pathway.
PG  - 189-201
LID - 10.1515/biol-2022-0022 [doi]
AB  - Traumatic brain injury (TBI) is a predominant cause of death and permanent 
      disability globally. In recent years, much emphasis has been laid on treatments 
      for TBI. Increasing evidence suggests that human umbilical cord mesenchymal stem 
      cells (HUCMSCs) can improve neurological repair after TBI. However, the clinical 
      use of HUCMSCs transplantation in TBI has been limited by immunological 
      rejection, ethical issues, and the risk of tumorigenicity. Many studies have 
      shown that HUCMSCs-derived exosomes may be an alternative approach for HUCMSCs 
      transplantation. We hypothesized that exosomes derived from HUCMSCs could inhibit 
      apoptosis after TBI, reduce neuroinflammation, and promote neurogenesis. A rat 
      model of TBI was established to investigate the efficiency of neurological 
      recovery with exosome therapy. We found that exosomes derived from HUCMSCs 
      significantly ameliorated sensorimotor function and spatial learning in rats 
      after TBI. Moreover, HUCMSCs-derived exosomes significantly reduced 
      proinflammatory cytokine expression by suppressing the NF-kappaB signaling pathway. 
      Furthermore, we found that HUCMSC-derived exosomes inhibited neuronal apoptosis, 
      reduced inflammation, and promoted neuron regeneration in the injured cortex of 
      rats after TBI. These results indicate that HUCMSCs-derived exosomes may be a 
      promising therapeutic strategy for TBI.
CI  - (c) 2022 Zhen-Wen Zhang et al., published by De Gruyter.
FAU - Zhang, Zhen-Wen
AU  - Zhang ZW
AD  - Department of Encephalopathy, Affiliated Hospital of Gansu University of Chinese 
      Medicine, Lanzhou 730000, Gansu, China.
AD  - Tianjin Key Laboratory of Neurotrauma Repair, Pingjin Hospital Brain Center, 
      Characteristic Medical Center of PAPF, Tianjin 300162, China.
AD  - College of Integrated Traditional Chinese and Western Medicine, Gansu University 
      of Chinese Medicine, Lanzhou 730000, Gansu, China.
FAU - Wei, Pan
AU  - Wei P
AD  - Department of Neurosurgery, The First People's Hospital of Long Quan Yi District, 
      Cheng Du 610000, Si Chuan, China.
FAU - Zhang, Gui-Jun
AU  - Zhang GJ
AD  - Department of Neurosurgery, West China Medical School, West China Hospital, 
      Sichuan University, Chengdu 610041, Sichuan, China.
FAU - Yan, Jing-Xing
AU  - Yan JX
AD  - Department of Encephalopathy, Affiliated Hospital of Gansu University of Chinese 
      Medicine, Lanzhou 730000, Gansu, China.
AD  - College of Integrated Traditional Chinese and Western Medicine, Gansu University 
      of Chinese Medicine, Lanzhou 730000, Gansu, China.
FAU - Zhang, Sai
AU  - Zhang S
AD  - Tianjin Key Laboratory of Neurotrauma Repair, Pingjin Hospital Brain Center, 
      Characteristic Medical Center of PAPF, Tianjin 300162, China.
FAU - Liang, Jin
AU  - Liang J
AD  - Tianjin Key Laboratory of Neurotrauma Repair, Pingjin Hospital Brain Center, 
      Characteristic Medical Center of PAPF, Tianjin 300162, China.
FAU - Wang, Xiao-Li
AU  - Wang XL
AD  - Tianjin Key Laboratory of Neurotrauma Repair, Pingjin Hospital Brain Center, 
      Characteristic Medical Center of PAPF, Tianjin 300162, China.
LA  - eng
PT  - Journal Article
DEP - 20220317
PL  - Poland
TA  - Open Life Sci
JT  - Open life sciences
JID - 101669614
PMC - PMC8932398
OTO - NOTNLM
OT  - NF-kappaB
OT  - exosomes
OT  - human umbilical cord mesenchymal stem cells
OT  - neurological recovery
OT  - traumatic brain injury
COIS- Conflict of interest: Authors state no conflict of interest.
EDAT- 2022/04/14 06:00
MHDA- 2022/04/14 06:01
PMCR- 2022/03/17
CRDT- 2022/04/13 05:36
PHST- 2021/08/01 00:00 [received]
PHST- 2021/12/13 00:00 [revised]
PHST- 2022/01/03 00:00 [accepted]
PHST- 2022/04/13 05:36 [entrez]
PHST- 2022/04/14 06:00 [pubmed]
PHST- 2022/04/14 06:01 [medline]
PHST- 2022/03/17 00:00 [pmc-release]
AID - biol-2022-0022 [pii]
AID - 10.1515/biol-2022-0022 [doi]
PST - epublish
SO  - Open Life Sci. 2022 Mar 17;17(1):189-201. doi: 10.1515/biol-2022-0022. 
      eCollection 2022.