PMID- 35415307
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220414
IS  - 2452-199X (Electronic)
IS  - 2452-199X (Linking)
VI  - 18
DP  - 2022 Dec
TI  - Reducing relapse and accelerating osteogenesis in rapid maxillary expansion using 
      an injectable mesoporous bioactive glass/fibrin glue composite hydrogel.
PG  - 507-525
LID - 10.1016/j.bioactmat.2022.03.001 [doi]
AB  - Rapid maxillary expansion (RME), as a common treatment for craniomaxillofacial 
      deformity, faces the challenge of high relapse rates and unsatisfactory 
      therapeutic effects. In this study, a standardized Sprague-Dawley (SD) rat RME 
      model was first established with a modified expander as well as retainer design 
      and optimized anterior maxillary expanding force of 100 g which exerted the most 
      synchronized mobility of mid-palatal suture and incisors. Via the standardized 
      model, the high relapse rate was proven to be attributed to insufficient 
      osteogenesis in expanded suture, requiring long-term retainer wearing in clinical 
      situations. To reduce the relapse rate, mesoporous bioactive glass/fibrin glue 
      (MBG/FG) composite hydrogels were developed for an in situ minimal invasive 
      injection that enhance osteogenesis in the expanded palate. The component of 
      1 wt% MBG was adopted for enhanced mechanical strength, matched degradation rate 
      and ion dissolution, excellent in vitro biocompatibility and osteoinductivity. 
      Effects of 1%MBG/FG composite hydrogel on osteogenesis in expanded mid-palatal 
      sutures with/without retention were evaluated in the standardized model. The 
      results demonstrated that injection of 1%MBG/FG composite hydrogel significantly 
      promoted bone formation within the expanded mid-palatal suture, inhibited 
      osteoclastogenesis and benefited the balance of bone remodeling towards 
      osteogenesis. Combination of retainer and injectable biomaterial was demonstrated 
      as a promising treatment to reduce relapse rate and enhance osteogenesis after 
      RME. The model establishment and the composite hydrogel development in this 
      article might provide new insight to other craniomaxillofacial deformity 
      treatment and design of bone-repairing biomaterials with higher regenerative 
      efficiency.
CI  - (c) 2022 The Authors.
FAU - Zhao, Hanjiang
AU  - Zhao H
AD  - Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine, College of 
      Stomatology, Shanghai Jiao Tong University, National Clinical Research Center for 
      Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research 
      Institute of Stomatology, Shanghai, 200011, PR China.
FAU - Wang, Xiangyu
AU  - Wang X
AD  - Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine, College of 
      Stomatology, Shanghai Jiao Tong University, National Clinical Research Center for 
      Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research 
      Institute of Stomatology, Shanghai, 200011, PR China.
FAU - Jin, Anting
AU  - Jin A
AD  - Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine, College of 
      Stomatology, Shanghai Jiao Tong University, National Clinical Research Center for 
      Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research 
      Institute of Stomatology, Shanghai, 200011, PR China.
FAU - Wang, Minjiao
AU  - Wang M
AD  - Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine, College of 
      Stomatology, Shanghai Jiao Tong University, National Clinical Research Center for 
      Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research 
      Institute of Stomatology, Shanghai, 200011, PR China.
FAU - Wang, Zeying
AU  - Wang Z
AD  - Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine, College of 
      Stomatology, Shanghai Jiao Tong University, National Clinical Research Center for 
      Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research 
      Institute of Stomatology, Shanghai, 200011, PR China.
FAU - Huang, Xingtai
AU  - Huang X
AD  - Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine, College of 
      Stomatology, Shanghai Jiao Tong University, National Clinical Research Center for 
      Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research 
      Institute of Stomatology, Shanghai, 200011, PR China.
FAU - Dai, Jiewen
AU  - Dai J
AD  - Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine, College of 
      Stomatology, Shanghai Jiao Tong University, National Clinical Research Center for 
      Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research 
      Institute of Stomatology, Shanghai, 200011, PR China.
FAU - Wang, Xudong
AU  - Wang X
AD  - Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine, College of 
      Stomatology, Shanghai Jiao Tong University, National Clinical Research Center for 
      Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research 
      Institute of Stomatology, Shanghai, 200011, PR China.
FAU - Lin, Dan
AU  - Lin D
AD  - Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine, College of 
      Stomatology, Shanghai Jiao Tong University, National Clinical Research Center for 
      Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research 
      Institute of Stomatology, Shanghai, 200011, PR China.
AD  - Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China.
FAU - Shen, Steve Gf
AU  - Shen SG
AD  - Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's 
      Hospital, Shanghai Jiao Tong University School of Medicine, College of 
      Stomatology, Shanghai Jiao Tong University, National Clinical Research Center for 
      Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research 
      Institute of Stomatology, Shanghai, 200011, PR China.
AD  - Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China.
LA  - eng
PT  - Journal Article
DEP - 20220330
PL  - China
TA  - Bioact Mater
JT  - Bioactive materials
JID - 101685294
PMC - PMC8976096
OTO - NOTNLM
OT  - Bone regeneration
OT  - Injectable hydrogel
OT  - Mesoporous bioactive glass
OT  - Rapid maxillary expansion
OT  - Sutural distraction osteogenesis
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2022/04/14 06:00
MHDA- 2022/04/14 06:01
PMCR- 2022/03/30
CRDT- 2022/04/13 05:36
PHST- 2021/07/07 00:00 [received]
PHST- 2022/02/24 00:00 [revised]
PHST- 2022/03/01 00:00 [accepted]
PHST- 2022/04/13 05:36 [entrez]
PHST- 2022/04/14 06:00 [pubmed]
PHST- 2022/04/14 06:01 [medline]
PHST- 2022/03/30 00:00 [pmc-release]
AID - S2452-199X(22)00107-4 [pii]
AID - 10.1016/j.bioactmat.2022.03.001 [doi]
PST - epublish
SO  - Bioact Mater. 2022 Mar 30;18:507-525. doi: 10.1016/j.bioactmat.2022.03.001. 
      eCollection 2022 Dec.