PMID- 35415816
OWN - NLM
STAT- MEDLINE
DCOM- 20220706
LR  - 20230802
IS  - 1534-4681 (Electronic)
IS  - 1068-9265 (Print)
IS  - 1068-9265 (Linking)
VI  - 29
IP  - 8
DP  - 2022 Aug
TI  - BREAST-Q REACT: Clinical Reference Values for the BREAST-Q in Post-mastectomy 
      Breast Reconstruction Patients.
PG  - 5280-5293
LID - 10.1245/s10434-022-11521-4 [doi]
AB  - BACKGROUND: The BREAST-Q is the most commonly used patient-reported outcome 
      measure (PROM) for breast reconstruction research. However, clinical 
      implementation of this PROM has been impeded by a lack of context for score 
      interpretation. The aim of this study was to define reference values for the 
      BREAST-Q at discrete timepoints following surgery, generating a tool for 
      real-time score interpretation. METHODS: BREAST-Q scores were prospectively 
      obtained in women who underwent implant or autologous post-mastectomy breast 
      reconstruction preoperatively and for 2 years following surgery at Memorial Sloan 
      Kettering Cancer Center (MSK). Descriptive statistics were used to create 
      reference values for BREAST-Q satisfaction and quality-of-life subscales. 
      Reference values were externally validated by comparing patient characteristics 
      and BREAST-Q scores between the MSK and the Mastectomy Reconstruction Outcomes 
      Consortium (MROC) study cohorts. RESULTS: Overall, 3268 MSK patients and 2814 
      MROC patients were included for analysis. When MSK and MROC cohorts were compared 
      for validation, there were some statistical differences in BREAST-Q scores; 
      however, most of these differences did not meet the minimal clinically important 
      difference of 4 points. Reference values were used to create the BREAST-Q 
      Real-time Engagement and Communication Tool (REACT). CONCLUSIONS: Using a large 
      cohort of patients, we have defined BREAST-Q reference values for post-mastectomy 
      breast reconstruction patients for use in clinical practice. The BREAST-Q REACT 
      will help breast reconstruction providers gauge patient wellbeing and 
      satisfaction relative to the "average" breast reconstruction patient and 
      determine which patients may benefit from additional intervention.
CI  - (c) 2022. Society of Surgical Oncology.
FAU - Nelson, Jonas A
AU  - Nelson JA
AD  - Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan 
      Kettering Cancer Center, New York, NY, USA. Nelsonj1@mskcc.org.
FAU - Chu, Jacqueline J
AU  - Chu JJ
AD  - Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan 
      Kettering Cancer Center, New York, NY, USA. Nelsonj1@mskcc.org.
FAU - McCarthy, Colleen M
AU  - McCarthy CM
AD  - Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan 
      Kettering Cancer Center, New York, NY, USA.
FAU - Stern, Carrie S
AU  - Stern CS
AD  - Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan 
      Kettering Cancer Center, New York, NY, USA.
FAU - Shamsunder, Meghana G
AU  - Shamsunder MG
AD  - Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan 
      Kettering Cancer Center, New York, NY, USA.
FAU - Pusic, Andrea L
AU  - Pusic AL
AD  - Division of Plastic Surgery, Brigham and Women's Hospital, Boston, MA, USA.
FAU - Mehrara, Babak J
AU  - Mehrara BJ
AD  - Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan 
      Kettering Cancer Center, New York, NY, USA.
LA  - eng
GR  - P30 CA008748/CA/NCI NIH HHS/United States
GR  - P30CA008748/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20220412
PL  - United States
TA  - Ann Surg Oncol
JT  - Annals of surgical oncology
JID - 9420840
SB  - IM
CIN - Ann Surg Oncol. 2022 Aug;29(8):5294-5295. PMID: 35303179
MH  - *Breast Implants
MH  - *Breast Neoplasms/surgery
MH  - Communication
MH  - Female
MH  - Humans
MH  - *Mammaplasty
MH  - Mastectomy
MH  - Patient Reported Outcome Measures
MH  - Patient Satisfaction
MH  - Quality of Life
MH  - Reference Values
PMC - PMC10337694
MID - NIHMS1905941
OTO - NOTNLM
OT  - Autologous reconstruction
OT  - BREAST-Q
OT  - Breast reconstruction
OT  - Implant Reconstruction
OT  - Patient reported outcomes
OT  - Reference values
COIS- Declaration of Interest: Andrea Pusic is a codeveloper of the BREAST-Q, which is 
      owned by Memorial Sloan Kettering Cancer Center. She receives a portion of the 
      licensing fees (royalty payments) when the BREAST-Q is used in industry-sponsored 
      clinical trials. Babak Mehrara is a consultant for PureTech Corporation. The 
      remaining authors declare no conflicts of interest
EDAT- 2022/04/14 06:00
MHDA- 2022/07/07 06:00
PMCR- 2023/08/01
CRDT- 2022/04/13 05:38
PHST- 2021/10/25 00:00 [received]
PHST- 2022/01/08 00:00 [accepted]
PHST- 2022/04/14 06:00 [pubmed]
PHST- 2022/07/07 06:00 [medline]
PHST- 2022/04/13 05:38 [entrez]
PHST- 2023/08/01 00:00 [pmc-release]
AID - 10.1245/s10434-022-11521-4 [pii]
AID - 10.1245/s10434-022-11521-4 [doi]
PST - ppublish
SO  - Ann Surg Oncol. 2022 Aug;29(8):5280-5293. doi: 10.1245/s10434-022-11521-4. Epub 
      2022 Apr 12.