PMID- 35419355
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220415
IS  - 2296-4185 (Print)
IS  - 2296-4185 (Electronic)
IS  - 2296-4185 (Linking)
VI  - 10
DP  - 2022
TI  - Prediction of Femoral Strength Based on Bone Density and Biochemical Markers in 
      Elderly Men With Type 2 Diabetes Mellitus.
PG  - 855364
LID - 10.3389/fbioe.2022.855364 [doi]
LID - 855364
AB  - Purpose: Effects of bone density, bone turnover and advanced glycation end 
      products (AGEs) on femoral strength (FS) are still unclear in patients with type 
      2 diabetes mellitus (T2DM). This study aims to assess and predict femoral 
      strength and its influencing factors in elderly men with T2DM. Methods: T2DM 
      patients (n = 10, mean age, 66.98 years) and age-matched controls (n = 8, mean 
      age, 60.38 years) were recruited. Femoral bone mineral density (BMD) and serum 
      biochemical indices of all subjects were measured. FS was evaluated through 
      finite element analysis based on quantitative computed tomography. Multiple 
      linear regression was performed to obtain the best predictive models of FS and to 
      analyze the ability of predictors of FS in both groups. Results: FS (p = 0.034), 
      HbA1c (p = 0.000) and fasting blood glucose (p = 0.000) levels of T2DM group were 
      significantly higher than those of control group; however, the P1NP level (p = 
      0.034) was significantly lower. FS was positively correlated with femoral neck T 
      score (FNTS) (r = 0.794, p < 0.01; r = 0.881, p < 0.01) in both groups. FS was 
      correlated with age (r = -0.750, p < 0.05) and pentosidine (r = -0.673, p < 0.05) 
      in T2DM group. According to multiple linear regression, FNTS and P1NP both 
      contributed to FS in two groups. P1NP significantly improved the prediction of FS 
      in both groups, but significant effect of FNTS on predicting FS was only 
      presented in control group. Furthermore, pentosidine, age and HbA1c all played 
      significant roles in predicting FS of T2DM. Conclusion: Femoral strength was 
      higher in elderly men with T2DM, which might be caused by higher BMD and lower 
      bone turnover rate. Moreover, besides BMD and bone formation level, AGEs, blood 
      glucose and age might significantly impact the prediction of femoral strength in 
      T2DM.
CI  - Copyright (c) 2022 Jia, Gong, Zhang, Liu, Cen, Zhang and Fan.
FAU - Jia, Shaowei
AU  - Jia S
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Center for Biomedical Engineering, School of 
      Biological Science and Medical Engineering, Beihang University, Beijing, China.
FAU - Gong, He
AU  - Gong H
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Center for Biomedical Engineering, School of 
      Biological Science and Medical Engineering, Beihang University, Beijing, China.
FAU - Zhang, Yingying
AU  - Zhang Y
AD  - Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, 
      National Research Center for Rehabilitation Technical Aids, Beijing, China.
FAU - Liu, Hongmei
AU  - Liu H
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Center for Biomedical Engineering, School of 
      Biological Science and Medical Engineering, Beihang University, Beijing, China.
AD  - Rehabilitation Hospital, National Research Center for Rehabilitation Technical 
      Aids, Beijing, China.
FAU - Cen, Haipeng
AU  - Cen H
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Center for Biomedical Engineering, School of 
      Biological Science and Medical Engineering, Beihang University, Beijing, China.
FAU - Zhang, Rui
AU  - Zhang R
AD  - Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, 
      National Research Center for Rehabilitation Technical Aids, Beijing, China.
FAU - Fan, Yubo
AU  - Fan Y
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Center for Biomedical Engineering, School of 
      Biological Science and Medical Engineering, Beihang University, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20220328
PL  - Switzerland
TA  - Front Bioeng Biotechnol
JT  - Frontiers in bioengineering and biotechnology
JID - 101632513
PMC - PMC8995504
OTO - NOTNLM
OT  - bone turnover
OT  - femoral strength
OT  - finite element analysis
OT  - quantitative computed tomography
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/04/15 06:00
MHDA- 2022/04/15 06:01
PMCR- 2022/01/01
CRDT- 2022/04/14 05:22
PHST- 2022/01/15 00:00 [received]
PHST- 2022/03/03 00:00 [accepted]
PHST- 2022/04/14 05:22 [entrez]
PHST- 2022/04/15 06:00 [pubmed]
PHST- 2022/04/15 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 855364 [pii]
AID - 10.3389/fbioe.2022.855364 [doi]
PST - epublish
SO  - Front Bioeng Biotechnol. 2022 Mar 28;10:855364. doi: 10.3389/fbioe.2022.855364. 
      eCollection 2022.