PMID- 35420715
OWN - NLM
STAT- MEDLINE
DCOM- 20220712
LR  - 20230407
IS  - 1863-2378 (Electronic)
IS  - 1863-1959 (Print)
IS  - 1863-1959 (Linking)
VI  - 69
IP  - 5
DP  - 2022 Aug
TI  - Risk factors for antimicrobial resistance among Staphylococcus isolated from pets 
      living with a patient diagnosed with methicillin-resistant Staphylococcus aureus 
      infection.
PG  - 550-559
LID - 10.1111/zph.12946 [doi]
AB  - It has been suggested that pets play a critical role in the maintenance of 
      methicillin-resistant (MR) and multidrug-resistant (MDR) Staphylococcus spp. in 
      the household. We examined risk factors for carriage of antimicrobial-resistant 
      coagulase-positive staphylococci, with particular attention to Staphylococcus 
      aureus and Staphylococcus pseudintermedius isolated from pets living in 
      households of people diagnosed with methicillin-resistant S. aureus (MRSA) skin 
      or soft-tissue infection. We analyzed data collected cross-sectionally from a 
      study conducted in 2012 that evaluated the transmission of MRSA and other 
      staphylococci from humans, their pets and the environment (Pets and Environmental 
      Transmission of Staphylococci [PETS] study). We used unadjusted and adjusted 
      stratified logistic regression analyses with household-clustered standard errors 
      to evaluate the association between demographic, healthcare-related, 
      contact-related and environmental risk factors and MDR Staphylococcus spp. 
      isolated from dogs and cats. Staphylococcal isolates obtained from dogs (n = 63) 
      and cats (n = 47) were included in these analyses. The use of oral or injectable 
      antimicrobials by the pets during the prior year was the main risk factor of 
      interest. Based on our results, 50% (12/24) of S. aureus, 3.3% (1/30) of 
      S. pseudintermedius and 25% (14/56) of other coagulase-positive staphylococci 
      (CPS) were determined to be MDR. S. aureus isolates were more likely to be MDR 
      compared with S. pseudintermedius. We did not find a significant statistical 
      association between the use of oral or injectable antimicrobials in the prior 
      year and the presence of MDR bacteria. The results suggest that drivers of 
      antimicrobial resistance in household staphylococci may vary by bacterial 
      species, which could have implications for one health intervention strategies for 
      staphylococci and inform the investigation of other reverse zoonoses, such as 
      COVID-19.
CI  - (c) 2022 The Authors. Zoonoses and Public Health published by Wiley-VCH GmbH.
FAU - Ferradas, Cusi
AU  - Ferradas C
AUID- ORCID: 0000-0002-4315-7900
AD  - Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, 
      USA.
AD  - Emerging Diseases and Climate Change Research Unit, School of Public Health and 
      Administration, Universidad Peruana Cayetano Heredia (UPCH), San Martin de 
      Porres, Peru.
AD  - School of Veterinary Medicine, Universidad Peruana Cayetano Heredia (UPCH), San 
      Martin de Porres, Peru.
FAU - Cotter, Caitlin
AU  - Cotter C
AD  - Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, 
      USA.
FAU - Shahbazian, Jonathan H
AU  - Shahbazian JH
AD  - Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, 
      USA.
FAU - Iverson, Sally Ann
AU  - Iverson SA
AD  - Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, 
      USA.
FAU - Baron, Patrick
AU  - Baron P
AD  - Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, 
      USA.
AD  - Department of Health and Human Values, Davidson College, Davidson, North 
      Carolina, USA.
FAU - Misic, Ana M
AU  - Misic AM
AD  - Perelman School of Medicine, University of Pennsylvania, Philadelphia, 
      Pennsylvania, USA.
FAU - Brazil, Amy M
AU  - Brazil AM
AD  - Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, 
      USA.
FAU - Rankin, Shelley C
AU  - Rankin SC
AD  - School of Veterinary Medicine, University of Pennsylvania, Philadelphia, 
      Pennsylvania, USA.
FAU - Nachamkin, Irving
AU  - Nachamkin I
AD  - Perelman School of Medicine, University of Pennsylvania, Philadelphia, 
      Pennsylvania, USA.
FAU - Ferguson, Jacqueline M
AU  - Ferguson JM
AD  - Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, 
      USA.
FAU - Peng, Roger D
AU  - Peng RD
AD  - Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, 
      USA.
FAU - Bilker, Warren B
AU  - Bilker WB
AD  - Perelman School of Medicine, University of Pennsylvania, Philadelphia, 
      Pennsylvania, USA.
FAU - Lautenbach, Ebbing
AU  - Lautenbach E
AD  - Perelman School of Medicine, University of Pennsylvania, Philadelphia, 
      Pennsylvania, USA.
FAU - Morris, Daniel O
AU  - Morris DO
AD  - School of Veterinary Medicine, University of Pennsylvania, Philadelphia, 
      Pennsylvania, USA.
FAU - Lescano, Andres G
AU  - Lescano AG
AD  - Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, 
      USA.
AD  - Emerging Diseases and Climate Change Research Unit, School of Public Health and 
      Administration, Universidad Peruana Cayetano Heredia (UPCH), San Martin de 
      Porres, Peru.
FAU - Davis, Meghan F
AU  - Davis MF
AUID- ORCID: 0000-0002-3475-4578
AD  - Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, 
      USA.
LA  - eng
GR  - D43 TW007393/TW/FIC NIH HHS/United States
GR  - D43 TW009343/TW/FIC NIH HHS/United States
GR  - K01 OD019918/OD/NIH HHS/United States
GR  - K24 AI080942/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20220414
PL  - Germany
TA  - Zoonoses Public Health
JT  - Zoonoses and public health
JID - 101300786
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Coagulase)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/pharmacology
MH  - *Anti-Infective Agents
MH  - *COVID-19/veterinary
MH  - *Cat Diseases/microbiology
MH  - Cats
MH  - Coagulase
MH  - *Dog Diseases/epidemiology/microbiology
MH  - Dogs
MH  - Drug Resistance, Bacterial
MH  - Humans
MH  - *Methicillin-Resistant Staphylococcus aureus
MH  - Pets/microbiology
MH  - Risk Factors
MH  - *Staphylococcal Infections/epidemiology/microbiology/veterinary
MH  - Staphylococcus
MH  - Staphylococcus aureus
PMC - PMC9543542
OTO - NOTNLM
OT  - Staphylococcus
OT  - antimicrobial resistance
OT  - domestic animals
OT  - multidrug resistance
COIS- All the authors declare no conflict of interest.
EDAT- 2022/04/15 06:00
MHDA- 2022/07/14 06:00
PMCR- 2022/10/07
CRDT- 2022/04/14 12:09
PHST- 2022/01/04 00:00 [revised]
PHST- 2021/11/09 00:00 [received]
PHST- 2022/03/23 00:00 [accepted]
PHST- 2022/04/15 06:00 [pubmed]
PHST- 2022/07/14 06:00 [medline]
PHST- 2022/04/14 12:09 [entrez]
PHST- 2022/10/07 00:00 [pmc-release]
AID - ZPH12946 [pii]
AID - 10.1111/zph.12946 [doi]
PST - ppublish
SO  - Zoonoses Public Health. 2022 Aug;69(5):550-559. doi: 10.1111/zph.12946. Epub 2022 
      Apr 14.