PMID- 35421867 OWN - NLM STAT- MEDLINE DCOM- 20220614 LR - 20220802 IS - 1728-7731 (Electronic) IS - 1726-4901 (Linking) VI - 85 IP - 6 DP - 2022 Jun 1 TI - Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on low-grade appendiceal mucinous neoplasm: A single tertiary hospital experience. PG - 693-698 LID - 10.1097/JCMA.0000000000000730 [doi] AB - BACKGROUND: Low-grade appendiceal mucinous neoplasm (LAMN) is a rare disease, which prognostic factors were difficult to evaluate. Inflammation markers, like neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), were used as prognosticators for various cancers. This study aimed to investigate the prognostic value of pretreatment NLR and PLR on LAMN. METHODS: From January 2000 to September 2018, there were 57 patients diagnosed with LAMN in Taipei Veterans General Hospital. Patients diagnosed with mucinous cystadenoma, mucinous tumor with uncertain malignant potential before 2010 were also included based on previous classification. Clinical and pathological data were collected. Patients were separated into high-NLR (NLR-H) and low-NLR (NLR-L) groups according to cutoff value of 3. Similarly, they were separated into high-PLR (PLR-H), and low-PLR (PLR-L) groups with cutoff value of 300. Overall survival (OS) and recurrence-free survival (RFS) were analyzed. RESULTS: Among all patients, the median follow-up time was 42 months. Age, gender, clinical manifestations, type of surgery, and T stage were similar in different NLR and PLR groups. Both NLR-H and PLR-H groups had higher rate of M1 stage of diseases (22.7% vs 9.4%, p = 0.04; 57.1% vs 8.8%, p < 0.01, respectively). PLR-H group had more presence of pseudomyxoma peritonei (PMP) (57.1% vs 15.2%, p = 0.03). In univariate analysis, factors such as age, gender, tumor perforation, and operation did not have impact on OS nor RFS. On the other hand, M1b stage is the only significantly poor prognostic factor on RFS (hazard ratio, 57.96, 95% CI, 5.16-651.23, p < 0.01). CONCLUSION: Both NLR-H and PLR-H had more M1 stage of diseases, but they were not correlated to OS nor RFS. PLR-H group had higher rate of presence PMP. Nevertheless, patients with LAMN and cellular PMP (M1b stage) had a higher rate of recurrence, and other factors showed no statistical difference in OS nor RFS. CI - Copyright (c) 2022, the Chinese Medical Association. FAU - Kuan, Tai-Chuan AU - Kuan TC AD - Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. AD - Division of Colon & Rectal Surgery, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan, ROC. AD - Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC. FAU - Liang, Wen-Yi AU - Liang WY AD - Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC. AD - Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. FAU - Lin, Chun-Chi AU - Lin CC AD - Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. AD - Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC. FAU - Lin, Hung-Hsin AU - Lin HH AD - Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. AD - Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC. FAU - Huang, Sheng-Chieh AU - Huang SC AD - Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. AD - Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC. FAU - Cheng, Ho-Shuan AU - Cheng HS AD - Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. AD - Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC. FAU - Chang, Shih-Ching AU - Chang SC AD - Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. AD - Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC. FAU - Jiang, Jeng-Kai AU - Jiang JK AD - Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. AD - Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC. FAU - Lan, Yuan-Tzu AU - Lan YT AD - Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC. AD - Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC. LA - eng PT - Journal Article DEP - 20220414 PL - Netherlands TA - J Chin Med Assoc JT - Journal of the Chinese Medical Association : JCMA JID - 101174817 SB - IM MH - Blood Platelets MH - Humans MH - Lymphocytes MH - *Neoplasms, Glandular and Epithelial MH - *Neutrophils MH - Prognosis MH - Retrospective Studies MH - Tertiary Care Centers COIS- Conflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article. EDAT- 2022/04/15 06:00 MHDA- 2022/06/15 06:00 CRDT- 2022/04/14 20:17 PHST- 2022/04/15 06:00 [pubmed] PHST- 2022/06/15 06:00 [medline] PHST- 2022/04/14 20:17 [entrez] AID - 02118582-202206000-00007 [pii] AID - 10.1097/JCMA.0000000000000730 [doi] PST - ppublish SO - J Chin Med Assoc. 2022 Jun 1;85(6):693-698. doi: 10.1097/JCMA.0000000000000730. Epub 2022 Apr 14.