PMID- 35421887
OWN - NLM
STAT- MEDLINE
DCOM- 20220511
LR  - 20220511
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 13
IP  - 9
DP  - 2022 May 10
TI  - Effects of red raspberry polyphenols and metabolites on the biomarkers of 
      inflammation and insulin resistance in type 2 diabetes: a pilot study.
PG  - 5166-5176
LID - 10.1039/d1fo02090k [doi]
AB  - Berry fruits are rich in polyphenolic compounds (PCs) and may promote health 
      benefits. Anthocyanin (ACN) concentrations of red raspberry (RR) (Rubus idaeus) 
      extracts were 887.6 +/- 262.8 mug g(-1), consisting mainly of cyanidin-3-sophoroside 
      (C3S) equivalents. To test the efficacy of RR in diabetes treatment, seven 
      patients with type 2 diabetes mellitus (T2DM) were given one oral RR serving (123 
      g per day) for two weeks. Blood samples were drawn at the baseline (BSL) and 
      post-feeding (PF) periods for phenolic metabolite, inflammation and insulin 
      resistance (IR) biomarker analysis. Two urolithin conjugates, urolithin A 
      glucuronide (Uro-A glur) and urolithin A sulphate (Uro-A sulf) were identified in 
      the PF period in 5 of the 7 patients in nanomolar concentrations (1.6 +/- 0.7-63.2 
      +/- 31.2 nM). ACN-derived metabolites such as protocatechuic acid (PCA) and 
      3,4-dihydroxyphenylacetic acid (DOPAC) were at micromolar levels and were higher 
      during the PF period for diabetics and the levels were as follows: BSL: PCA = 0.6 
      +/- 0.4, DOPAC = 1.2 +/- 0.5; PF: PCA = 0.6 +/- 0.4, DOPAC = 1.1 +/- 0.6. The results 
      revealed significant reductions in high sensitivity C-reactive protein, hsCRP (p 
      = 0.01) and there was a downward trend in IR measured by the homeostatic model 
      assessment of insulin resistance (HOMA-IR, p = 0.0584) in T2DM patients. DOPAC 
      (1-100 muM) failed to stimulate insulin secretion in pancreatic beta-cells. The 
      multiplex assay showed variations in the cytokine levels between patients, but 
      differences were not significant. This study demonstrates a potential use of RR 
      in the treatment of inflammation and possibly IR as well in patients with type 2 
      diabetes.
FAU - Moreno Ucles, Reynaldo
AU  - Moreno Ucles R
AUID- ORCID: 0000-0002-7038-1860
AD  - Chronic Degenerative Disease Prevention Laboratory, School of Nutrition and Food 
      Sciences, Louisiana State University AgCenter, USA. jlosso@agcenter.lsu.edu.
FAU - Gonzalez-Sarrias, Antonio
AU  - Gonzalez-Sarrias A
AUID- ORCID: 0000-0002-3407-0678
AD  - Food and Technology Department, CEBAS-CSIC, Espinardo, Murcia, Spain.
FAU - Espin, Juan Carlos
AU  - Espin JC
AUID- ORCID: 0000-0002-1068-8692
AD  - Food and Technology Department, CEBAS-CSIC, Espinardo, Murcia, Spain.
FAU - Tomas-Barberan, Francisco A
AU  - Tomas-Barberan FA
AUID- ORCID: 0000-0002-0790-1739
AD  - Food and Technology Department, CEBAS-CSIC, Espinardo, Murcia, Spain.
FAU - Janes, Marlene
AU  - Janes M
AD  - Chronic Degenerative Disease Prevention Laboratory, School of Nutrition and Food 
      Sciences, Louisiana State University AgCenter, USA. jlosso@agcenter.lsu.edu.
FAU - Cheng, Henrique
AU  - Cheng H
AD  - Department of Comparative Biomedical Sciences, School of Veterinary Medicine, 
      Louisiana State University, Baton Rouge, LA, 70803, USA.
FAU - Finley, John
AU  - Finley J
AD  - Chronic Degenerative Disease Prevention Laboratory, School of Nutrition and Food 
      Sciences, Louisiana State University AgCenter, USA. jlosso@agcenter.lsu.edu.
FAU - Greenway, Frank
AU  - Greenway F
AUID- ORCID: 0000-0002-1766-6111
AD  - Pennington Biomedical Research Centre, Baton Rouge, LA 70808, USA.
FAU - Losso, Jack N
AU  - Losso JN
AUID- ORCID: 0000-0002-8187-7757
AD  - Chronic Degenerative Disease Prevention Laboratory, School of Nutrition and Food 
      Sciences, Louisiana State University AgCenter, USA. jlosso@agcenter.lsu.edu.
LA  - eng
PT  - Journal Article
DEP - 20220510
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Biomarkers)
RN  - 0 (Insulin)
RN  - 0 (Polyphenols)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid
MH  - Biomarkers
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Health Promotion
MH  - Humans
MH  - Inflammation/drug therapy
MH  - Insulin
MH  - *Insulin Resistance
MH  - Pilot Projects
MH  - Polyphenols/pharmacology
MH  - *Rubus
EDAT- 2022/04/15 06:00
MHDA- 2022/05/12 06:00
CRDT- 2022/04/14 20:17
PHST- 2022/04/15 06:00 [pubmed]
PHST- 2022/05/12 06:00 [medline]
PHST- 2022/04/14 20:17 [entrez]
AID - 10.1039/d1fo02090k [doi]
PST - epublish
SO  - Food Funct. 2022 May 10;13(9):5166-5176. doi: 10.1039/d1fo02090k.