PMID- 35422938
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 14
IP  - 3
DP  - 2022
TI  - Effects of low molecular weight heparin combined with hyperbaric oxygen on 
      neurologic function and coagulation factors in patients with intracranial venous 
      thrombosis.
PG  - 2101-2108
AB  - OBJECTIVE: To investigate the effects of low molecular weight heparin (LMWH) 
      combined with hyperbaric oxygen (HBO) on the neurologic function and coagulation 
      factors of patients with intracranial venous thrombosis (ICVT). METHODS: The 
      clinical data of 80 patients with ICVT admitted to the No. 2 Hospital of Baoding 
      from February 2020 to January 2021 were retrospectively analyzed. Patients were 
      assigned to a control group (n=32) and a research group (n=48) according to 
      different treatment methods. The neurological function score, and the levels of 
      D-dimer (D-D), fibrinogen (FIB), tumor necrosis factor-alpha (TNF-alpha), and C-reactive 
      protein (CRP) were compared between the two groups. The two groups were also 
      compared regarding the curative effect, toxic and side effects, as well as 
      quality of life (QoL). RESULTS: After treatment, the National Institutes of 
      Health Stroke Scale (NIHSS) score was significantly lower in the research group 
      compared to the control group. At 1, 2 and 3 weeks after treatment, the levels of 
      D-D and FIB, as well as inflammatory factors TNF-alpha and CRP were lower in the 
      research group compared to the control group. The overall response rate was 
      significantly higher in the research group compared to the control group, while 
      there was no significant difference in the total incidence of toxic and adverse 
      effects between the two groups. After treatment, the QoL of patients assessed by 
      the Generic Quality of Life Inventory-74 (GQOLI-74) from the domains of physical, 
      social, and psychological function as well as material life status was 
      significantly better in the research group. CONCLUSIONS: LMWH combined with HBO 
      can effectively improve the clinical efficacy and neurologic function of patients 
      with ICVT and reduce the levels of coagulation factors and inflammatory factors.
CI  - AJTR Copyright (c) 2022.
FAU - Liu, Bo-Feng
AU  - Liu BF
AD  - Department of Neurosurgery, The No. 2 Hospital of Baoding Baoding 071051, Hebei, 
      China.
FAU - Liu, Xiao-Hui
AU  - Liu XH
AD  - Operating Room of Qingyuan District People's Hospital Baoding 071100, Hebei, 
      China.
FAU - Dong, Xiao-Hui
AU  - Dong XH
AD  - Department of Neurosurgery, The No. 2 Hospital of Baoding Baoding 071051, Hebei, 
      China.
FAU - Ma, Ning
AU  - Ma N
AD  - Department of Neurosurgery, The No. 2 Hospital of Baoding Baoding 071051, Hebei, 
      China.
FAU - Zhang, Hui-Ping
AU  - Zhang HP
AD  - Department of Neurosurgery, The No. 2 Hospital of Baoding Baoding 071051, Hebei, 
      China.
FAU - Jiang, Li-Li
AU  - Jiang LL
AD  - Department of Neurosurgery, The No. 2 Hospital of Baoding Baoding 071051, Hebei, 
      China.
FAU - Liu, Yan-Qing
AU  - Liu YQ
AD  - Department of Neurosurgery, The No. 2 Hospital of Baoding Baoding 071051, Hebei, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20220315
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC8991144
OTO - NOTNLM
OT  - Low molecular weight heparin
OT  - coagulation factor
OT  - hyperbaric oxygen
OT  - intracranial venous thrombosis
OT  - neurological function
COIS- None.
EDAT- 2022/04/16 06:00
MHDA- 2022/04/16 06:01
PMCR- 2022/03/15
CRDT- 2022/04/15 05:24
PHST- 2021/12/27 00:00 [received]
PHST- 2022/02/21 00:00 [accepted]
PHST- 2022/04/15 05:24 [entrez]
PHST- 2022/04/16 06:00 [pubmed]
PHST- 2022/04/16 06:01 [medline]
PHST- 2022/03/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2022 Mar 15;14(3):2101-2108. eCollection 2022.