PMID- 35424505
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220416
IS  - 2046-2069 (Electronic)
IS  - 2046-2069 (Linking)
VI  - 12
IP  - 1
DP  - 2021 Dec 20
TI  - Synthetic strategy and structure-activity relationship (SAR) studies of 
      3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1, Lificiguat): a review.
PG  - 251-264
LID - 10.1039/d1ra08120a [doi]
AB  - Since 1994, YC-1 (Lificiguat, 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole) has 
      been synthesized, and many targets for special bioactivities have been explored, 
      such as stimulation of platelet-soluble guanylate cyclase, indirect elevation of 
      platelet cGMP levels, and inhibition of hypoxia-inducible factor-1 (HIF-1) and 
      NF-kappaB. Recently, Riociguat(R), the first soluble guanylate cyclase (sGC) stimulator 
      drug used to treat pulmonary hypertension and pulmonary arterial hypertension, 
      was derived from the YC-1 structure. In this review, we aim to highlight the 
      synthesis and structure-activity relationships in the development of YC-1 analogs 
      and their possible indications.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Yu, Ko-Hua
AU  - Yu KH
AD  - School of Pharmacy College of Medicine, National Cheng Kung University Tainan 701 
      Taiwan z10308005@email.ncku.edu.tw.
FAU - Hung, Hsin-Yi
AU  - Hung HY
AUID- ORCID: 0000-0001-7666-2420
AD  - School of Pharmacy College of Medicine, National Cheng Kung University Tainan 701 
      Taiwan z10308005@email.ncku.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211220
PL  - England
TA  - RSC Adv
JT  - RSC advances
JID - 101581657
PMC - PMC8978903
COIS- There are no conflicts to declare.
EDAT- 2022/04/16 06:00
MHDA- 2022/04/16 06:01
PMCR- 2021/12/20
CRDT- 2022/04/15 05:28
PHST- 2021/11/05 00:00 [received]
PHST- 2021/12/14 00:00 [accepted]
PHST- 2022/04/15 05:28 [entrez]
PHST- 2022/04/16 06:00 [pubmed]
PHST- 2022/04/16 06:01 [medline]
PHST- 2021/12/20 00:00 [pmc-release]
AID - d1ra08120a [pii]
AID - 10.1039/d1ra08120a [doi]
PST - epublish
SO  - RSC Adv. 2021 Dec 20;12(1):251-264. doi: 10.1039/d1ra08120a. eCollection 2021 Dec 
      20.