PMID- 35425843
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220429
IS  - 2325-9671 (Print)
IS  - 2325-9671 (Electronic)
IS  - 2325-9671 (Linking)
VI  - 10
IP  - 4
DP  - 2022 Apr
TI  - Effectiveness of Platelet-Rich Plasma for Lateral Epicondylitis: A Systematic 
      Review and Meta-analysis Based on Achievement of Minimal Clinically Important 
      Difference.
PG  - 23259671221086920
LID - 10.1177/23259671221086920 [doi]
LID - 23259671221086920
AB  - BACKGROUND: The effectiveness of platelet-rich plasma (PRP) injection in the 
      treatment of lateral epicondylitis remains debatable. PURPOSE: To evaluate the 
      effectiveness of PRP in lateral epicondylitis treatment using minimal clinically 
      important difference (MCID) values as a reference and to investigate if leukocyte 
      content can influence the effectiveness of the therapy. STUDY DESIGN: Systematic 
      review; Level of evidence, 4. METHODS: Following the PRISMA (Preferred Reporting 
      Items for Systematic Reviews and Meta-Analyses) guidelines, the authors searched 
      the Medline and Scopus databases for studies on lateral epicondylitis and PRP 
      therapy that used the following patient-reported outcome measures (PROMs): visual 
      analog scale (VAS) for pain; Disabilities of the Arm, Shoulder and Hand (DASH); 
      Patient-Rated Tennis Elbow Evaluation (PRTEE); and Mayo Clinic Performance Index 
      (MAYO). The weighted arithmetic means for the PROMs were calculated at baseline 
      (week 0) and follow-up weeks 4, 8, 12, 24, 52, and 104. The mean differences in 
      outcomes (DeltaVAS, DeltaDASH, DeltaPRTEE, and DeltaMAYO) were compared with the MCID values at 
      each follow-up point. In addition, the effectiveness of leukocyte-rich PRP 
      (LR-PRP) versus leukocyte-poor PRP (LP-PRP) was also compared. The Student t test 
      was used in all analyses. RESULTS: A total of 26 studies were included in the 
      analysis. After PRP injection, all PROM scores improved with time. The scores 
      improved significantly from baseline to each follow-up time (P < .0001), with the 
      exception of the PRTEE (no significant difference at follow-up weeks 12 and 52). 
      The mean difference in scores from baseline exceeded the respective MCIDs from 
      weeks 4 to 104 for the VAS and DASH, from weeks 4 to 52 for the MAYO, and from 
      weeks 8 to 52 for the PRTEE. The MCID for each of the PROMs was exceeded at 
      almost every observation period in both the LR-PRP and the LP-PRP systems. 
      CONCLUSION: Based on comparisons with the MCID values of commonly used outcome 
      scores, PRP seems to be an effective form of treatment for lateral epicondylitis. 
      Both the LR- PRP and the LP- PRP systems were effective in the context of meeting 
      the MCID.
CI  - (c) The Author(s) 2022.
FAU - Niemiec, Pawel
AU  - Niemiec P
AD  - Department of Biochemistry and Medical Genetics, School of Health Sciences in 
      Katowice, Medical University of Silesia in Katowice, Katowice, Poland.
FAU - Szyluk, Karol
AU  - Szyluk K
AD  - District Hospital of Orthopaedics and Trauma Surgery, Piekary Slaskie, Poland.
AD  - Department of Physiotherapy, Faculty of Health Sciences in Katowice, Medical 
      University of Silesia in Katowice, Katowice, Poland.
FAU - Jarosz, Alicja
AU  - Jarosz A
AD  - Department of Biochemistry and Medical Genetics, School of Health Sciences in 
      Katowice, Medical University of Silesia in Katowice, Katowice, Poland.
FAU - Iwanicki, Tomasz
AU  - Iwanicki T
AD  - Department of Biochemistry and Medical Genetics, School of Health Sciences in 
      Katowice, Medical University of Silesia in Katowice, Katowice, Poland.
FAU - Balcerzyk, Anna
AU  - Balcerzyk A
AD  - Department of Biochemistry and Medical Genetics, School of Health Sciences in 
      Katowice, Medical University of Silesia in Katowice, Katowice, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220408
PL  - United States
TA  - Orthop J Sports Med
JT  - Orthopaedic journal of sports medicine
JID - 101620522
PMC - PMC9003647
OTO - NOTNLM
OT  - lateral epicondylitis
OT  - minimal clinically important difference
OT  - platelet-rich plasma
OT  - tennis elbow
COIS- One or more of the authors has declared the following potential conflict of 
      interest or source of funding: This study was funded by Medical University of 
      Silesia in Katowice, Poland (grant No. KNW-1-008/N/7/K). AOSSM checks author 
      disclosures against the Open Payments Database (OPD). AOSSM has not conducted an 
      independent investigation on the OPD and disclaims any liability or 
      responsibility relating thereto.
EDAT- 2022/04/16 06:00
MHDA- 2022/04/16 06:01
PMCR- 2022/04/08
CRDT- 2022/04/15 05:32
PHST- 2021/12/01 00:00 [received]
PHST- 2022/01/10 00:00 [accepted]
PHST- 2022/04/15 05:32 [entrez]
PHST- 2022/04/16 06:00 [pubmed]
PHST- 2022/04/16 06:01 [medline]
PHST- 2022/04/08 00:00 [pmc-release]
AID - 10.1177_23259671221086920 [pii]
AID - 10.1177/23259671221086920 [doi]
PST - epublish
SO  - Orthop J Sports Med. 2022 Apr 8;10(4):23259671221086920. doi: 
      10.1177/23259671221086920. eCollection 2022 Apr.