PMID- 35426103
OWN - NLM
STAT- MEDLINE
DCOM- 20220722
LR  - 20221207
IS  - 1439-3999 (Electronic)
IS  - 0023-2165 (Linking)
VI  - 239
IP  - 7
DP  - 2022 Jul
TI  - A Pediatric COVID-19 Study: Retinal Nerve Fiber Layer, Ganglion Cell Layer, and 
      Alterations in Choroidal Thickness in Swept-Source OCT Measurements.
PG  - 916-922
LID - 10.1055/a-1785-3863 [doi]
AB  - PURPOSE: To investigate early covid measurements of central macular thickness 
      (CMT), retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) thickness, and 
      choroidal thickness (ChT) in children recovered from coronavirus disease 2019 
      (COVID-19). METHODS: This cross-sectional study was carried out 4 weeks after 
      completed COVID-19 treatment. The diagnosis of the Alpha variant COVID-19 was 
      made by the polymerase chain reaction test after prediagnosis with clinical, 
      laboratory, and radiological findings. A total of 46 children were included in 
      the study. Pediatric patients who received COVID-19 treatment comprised the 
      COVID-19 group (24 children), and healthy children were enrolled in the control 
      group (22 children). Only the right eyes of the participants were enrolled in the 
      study. All pediatric patients in the COVID-19 group required hospitalization 
      without the need for intubation. Swept-source optical coherence tomography 
      (SS-OCT) was used to measure CMT, RNFL, and GCL thickness, and ChT measurements. 
      RESULTS: The COVID-19 and control groups had similar mean values of visual 
      acuity, intraocular pressure, spherical equivalent, axial length, and CMT 
      (p > 0.05 for all). RNFL thickening, GCL, and choroidal thinning were observed in 
      all SS-OCT measurements of COVID-19 children. However, RNFL thickening was 
      significant only in the global and nasal peripapillary quadrants. GCL thinning 
      was significant in the nasal/inferior sector (p < 0.002 for all). Some 
      significant correlations were observed between the mean levels of inflammatory 
      markers and OCT measurements (p < 0.002). CONCLUSION: This study may be among the 
      first reports of SS-OCT examination of COVID-19 children. OCT measurements showed 
      changes in retinal and ChT in the COVID-19 children as in adult patients.
CI  - Thieme. All rights reserved.
FAU - Akpolat, Cetin
AU  - Akpolat C
AUID- ORCID: 0000-0002-7443-6902
AD  - Ophthalmology, Sisli Hamidiye Etfal Egitim ve Arastirma Hastanesi, Halaskargazi 
      cd. Etfal sok., Istanbul, Turkey.
FAU - Cetinkaya, Tugba
AU  - Cetinkaya T
AD  - Ophthalmology, Samsun Education and Research Hospital, Samsun, Turkey.
FAU - Kurt, Muhammed M
AU  - Kurt MM
AD  - Ophthalmology, Samsun Education and Research Hospital, Samsun, Turkey.
LA  - eng
PT  - Journal Article
TT  - Eine padiatrische COVID-19-Studie: Veranderungen der Netzhautnervenfaserschicht, 
      Ganglienzellschicht und Aderhautdicke bei Swept-Source-OCT-Messungen.
DEP - 20220414
PL  - Germany
TA  - Klin Monbl Augenheilkd
JT  - Klinische Monatsblatter fur Augenheilkunde
JID - 0014133
RN  - SARS-CoV-2 variants
SB  - IM
MH  - Adult
MH  - Child
MH  - Cross-Sectional Studies
MH  - Humans
MH  - *Nerve Fibers
MH  - Retinal Ganglion Cells
MH  - SARS-CoV-2
MH  - Tomography, Optical Coherence/methods
MH  - *COVID-19 Drug Treatment
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/04/16 06:00
MHDA- 2022/07/23 06:00
CRDT- 2022/04/15 05:33
PHST- 2022/04/16 06:00 [pubmed]
PHST- 2022/07/23 06:00 [medline]
PHST- 2022/04/15 05:33 [entrez]
AID - 10.1055/a-1785-3863 [doi]
PST - ppublish
SO  - Klin Monbl Augenheilkd. 2022 Jul;239(7):916-922. doi: 10.1055/a-1785-3863. Epub 
      2022 Apr 14.