PMID- 35426222
OWN - NLM
STAT- MEDLINE
DCOM- 20220714
LR  - 20221205
IS  - 1529-8019 (Electronic)
IS  - 1396-0296 (Linking)
VI  - 35
IP  - 7
DP  - 2022 Jul
TI  - Laser therapy and light sources for labial lentigines in patients with 
      Peutz-Jeghers syndrome.
PG  - e15519
LID - 10.1111/dth.15519 [doi]
AB  - Labial lentigines associated with Peutz-Jeghers syndrome are challenging and 
      represent a cosmetic problem. Laser and intense-pulsed light sources (IPLS) can 
      be used to treat these macules. However, there are few guidelines regarding the 
      different types of protocols found in the literature. Thus, the purpose of this 
      study was to review the pertinent literature on lasers and IPLS as therapy for 
      labial lentigines in patients with Peutz-Jeghers syndrome. A detailed literature 
      search was conducted in seven databases (Cochrane Library, Embase, Lilacs, 
      PubMed, SciELO, Scopus and Web of Science) to November 2020. Data were extracted 
      and analyzed from selected studies including study design, sample size, 
      participants' skin color, age, and gender, parameters of the laser or IPLS used, 
      interval and total sessions of laser application, results obtained, follow-up 
      time and side effects. Thirteen out of 124 published studies met our eligibility 
      criteria, covering 81 patients. Ten types of lasers and IPLS were used, and most 
      of the sample (n = 57) was treated with Q-switch Alexandrite Laser (QSAL). The 
      total number of sessions ranged from 1 to 12 and the interval between sessions 
      ranged from 2 to 16 weeks. All studies have shown satisfactory results, with no 
      further complications. The follow-up ranged from 2 to 97 months. Laser therapy 
      and IPLS are effective in the treatment of lentigines associated with PJS. 
      Although QSAL was used in 70.3% of the sample, different types of lasers showed 
      comparable satisfactory results.
CI  - (c) 2022 Wiley Periodicals LLC.
FAU - Medeiros, Yuri de Lima
AU  - Medeiros YL
AUID- ORCID: 0000-0002-4013-7752
AD  - School of Dentistry, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.
FAU - Faria, Luan Viana
AU  - Faria LV
AD  - School of Dentistry, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.
FAU - Chandretti, Paula Carolina de Souza
AU  - Chandretti PCS
AD  - School of Dentistry, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.
FAU - Mainenti, Pietro
AU  - Mainenti P
AD  - Department of Pathology, School of Medicine, Universidade Presidente Antonio 
      Carlos, Juiz de Fora, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220420
PL  - United States
TA  - Dermatol Ther
JT  - Dermatologic therapy
JID - 9700070
SB  - IM
MH  - Humans
MH  - *Laser Therapy
MH  - *Lentigo/radiotherapy
MH  - *Lip Diseases
MH  - *Low-Level Light Therapy/adverse effects/methods
MH  - *Melanosis
MH  - *Peutz-Jeghers Syndrome/complications/diagnosis/radiotherapy
OTO - NOTNLM
OT  - Lentigo
OT  - Peutz-Jeghers syndrome
OT  - laser therapy
OT  - lasers
OT  - lips
EDAT- 2022/04/16 06:00
MHDA- 2022/07/15 06:00
CRDT- 2022/04/15 05:34
PHST- 2022/03/25 00:00 [revised]
PHST- 2021/03/31 00:00 [received]
PHST- 2022/04/12 00:00 [accepted]
PHST- 2022/04/16 06:00 [pubmed]
PHST- 2022/07/15 06:00 [medline]
PHST- 2022/04/15 05:34 [entrez]
AID - 10.1111/dth.15519 [doi]
PST - ppublish
SO  - Dermatol Ther. 2022 Jul;35(7):e15519. doi: 10.1111/dth.15519. Epub 2022 Apr 20.