PMID- 35427812
OWN - NLM
STAT- MEDLINE
DCOM- 20220608
LR  - 20220705
IS  - 1532-8430 (Electronic)
IS  - 0022-0736 (Linking)
VI  - 72
DP  - 2022 May-Jun
TI  - Prognostic significance of addition of electrocardiographic findings to the 
      MAGGIC heart failure risk score.
PG  - 102-108
LID - S0022-0736(22)00045-0 [pii]
LID - 10.1016/j.jelectrocard.2022.03.003 [doi]
AB  - BACKGROUND: The Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) is a 
      scoring system that is easy to use in outpatient or inpatient settings and was 
      developed to predict the survival of heart failure (HF) patients after 
      hospitalization. AIM: This study aims to determine the prognostic significance of 
      MAGGIC risk score combined with electrocardiography (ECG) parameters in 
      decompensated patients with heart failure with reduced left ventricular ejection 
      fraction (HFrEF) who were hospitalized for worsening HF. METHODS: A total of 562 
      HF patients with New York Heart Association (NYHA) II-IV functional class who 
      were discharged after hospitalization for decompensated HF between 2013 and 2018 
      in a single center were included. MAGGIC risk scores of all participating 
      patients were calculated according to baseline characteristics gathered using 
      data from the initial hospitalization for HF. In addition, electrocardiographic 
      findings of all patients were examined. RESULTS: During the follow-up period (4.5 
      +/- 1.2 years) 177 patients died. MAGGIC scores were observed to be higher in 
      non-survivors compared to surviving patients (28.69 +/- 7.01 vs. 22.82 +/- 6.05, p < 
      0.001). After a multivariate analysis, MAGGIC score (OR:1.090, p < 0.001), 
      development of cardio-renal syndrome (OR:2.035, p < 0.001), presence of left 
      bundle branch block (LBBB) (OR:1.931, p < 0.001), atrial fibrillation (AF) 
      (OR:1.817, p < 0.001), and fragmented QRS (fQRS) (OR:1.671, p = 0.002) on ECG 
      were found to be independent predictors of mortality. While the MAGGIC score was 
      shown to predict mortality (AUC = 0.739), its predictive power was improved when 
      combined with AF (AUC = 0.752), LBBB (AUC = 0.745), and fQRS (AUC = 0.757) 
      respectively, as well as in the combined final model (MAGGIC score, AF, LBBB, 
      fQRS) (AUC = 0.787). CONCLUSIONS: Our findings showed that addition of 
      electrocardiographic findings to the MAGGIC heart failure risk score has 
      prognostic significance in decompensated patients with HFrEF.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Ikitimur, Baris
AU  - Ikitimur B
AD  - Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Department of 
      Cardiology, Istanbul, Turkey.
FAU - Barman, Hasan Ali
AU  - Barman HA
AD  - Istanbul University-Cerrahpasa, Institute of Cardiology, Department of 
      Cardiology, Istanbul, Turkey.
FAU - Dogan, Omer
AU  - Dogan O
AD  - Istanbul University-Cerrahpasa, Institute of Cardiology, Department of 
      Cardiology, Istanbul, Turkey. Electronic address: omrdgn123@gmail.com.
FAU - Atici, Adem
AU  - Atici A
AD  - Istanbul Medeniyet University, Faculty of Medicine, Goztepe Training and Research 
      Hospital, Department of Cardiology, Istanbul, Turkey.
FAU - Meric, Bengisu Keskin
AU  - Meric BK
AD  - Istanbul University-Cerrahpasa, Institute of Cardiology, Department of 
      Cardiology, Istanbul, Turkey.
FAU - Dogan, Sait Mesut
AU  - Dogan SM
AD  - Istanbul University-Cerrahpasa, Institute of Cardiology, Department of 
      Cardiology, Istanbul, Turkey.
FAU - Enar, Rasim
AU  - Enar R
AD  - Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Department of 
      Cardiology, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20220318
PL  - United States
TA  - J Electrocardiol
JT  - Journal of electrocardiology
JID - 0153605
SB  - IM
MH  - *Atrial Fibrillation
MH  - Chronic Disease
MH  - Electrocardiography
MH  - *Heart Failure
MH  - Humans
MH  - Prognosis
MH  - Risk Factors
MH  - Stroke Volume
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Electrocardiogram
OT  - MAGGIC risk score
OT  - Prognosis
EDAT- 2022/04/16 06:00
MHDA- 2022/06/09 06:00
CRDT- 2022/04/15 20:11
PHST- 2022/01/03 00:00 [received]
PHST- 2022/02/17 00:00 [revised]
PHST- 2022/03/09 00:00 [accepted]
PHST- 2022/04/16 06:00 [pubmed]
PHST- 2022/06/09 06:00 [medline]
PHST- 2022/04/15 20:11 [entrez]
AID - S0022-0736(22)00045-0 [pii]
AID - 10.1016/j.jelectrocard.2022.03.003 [doi]
PST - ppublish
SO  - J Electrocardiol. 2022 May-Jun;72:102-108. doi: 
      10.1016/j.jelectrocard.2022.03.003. Epub 2022 Mar 18.