PMID- 35427914
OWN - NLM
STAT- MEDLINE
DCOM- 20220503
LR  - 20221207
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 16
IP  - 4
DP  - 2022 Apr
TI  - Positive association of branched-chain amino acids with triglyceride and glycated 
      haemoglobin in Indian patients with type 2 diabetes mellitus.
PG  - 102481
LID - S1871-4021(22)00095-9 [pii]
LID - 10.1016/j.dsx.2022.102481 [doi]
AB  - BACKGROUND AND AIMS: Over the past few years, branched-chain amino acids (BCAAs) 
      are increasingly being linked to insulin resistance and type 2 diabetes mellitus 
      (T2DM), but their relevance for metabolic dyslipidaemia in T2DM is unclear. This 
      study aims to determine the plasma and urinary BCAAs and their association with 
      insulin resistance, lipid profile and glycated haemoglobin in patients with T2DM 
      among Indian adults. METHODS: In this analytical cross-sectional study, a total 
      of eighty subjects were recruited, 40 T2DM cases and 40 healthy controls. Blood 
      samples collected were subjected to fasting blood sugar (FBS), lipid profile, 
      HbA1c, insulin and BCAAs analysis and urine samples were assessed for BCAAs. All 
      associations were assessed using Spearman Rank Correlation. RESULTS: The plasma 
      levels of BCAAs were significantly higher (p < 0.05) in subjects with T2DM than 
      in control subjects. Spearman Rank Correlation analyses revealed a 
      non-significant (p = 0.21) but positive association between BCAAs and homeostasis 
      model assessment of insulin resistance (HOMA-IR) in patients with T2DM (Rho: 
      0.27). Among lipid profile parameters, only triglycerides had a significant 
      positive correlation to plasma BCAAs in cases (Rho: 0.5971) but not in control 
      subjects. Findings also revealed a significant positive (p < 0.05) association 
      between plasma BCAAs and HbA1c in patients with T2DM (Rho: 0.5325). Urinary BCAAs 
      levels had a non-significant increase in T2DM subjects and did not show any 
      significant correlation with other parameters assessed. CONCLUSION: Elevated 
      levels of plasma BCAAs are positively associated with triglyceride and HbA1c. 
      They could serve as an effective marker for the assessment of metabolic 
      dyslipidaemia in subjects with T2DM. Further, large scale studies are needed for 
      confirmation of the same.
CI  - Copyright (c) 2022 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Sankanagoudar, Shrimanjunath
AU  - Sankanagoudar S
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 
      Rajasthan, India. Electronic address: doc_manjunath@yahoo.co.in.
FAU - Shukla, Ravindra
AU  - Shukla R
AD  - Department of Endocrinology and Metabolism, All India Institute of Medical 
      Sciences, Jodhpur, Rajasthan, India.
FAU - Shukla, Kamla Kant
AU  - Shukla KK
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 
      Rajasthan, India.
FAU - Sharma, Praveen
AU  - Sharma P
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 
      Rajasthan, India.
LA  - eng
PT  - Journal Article
DEP - 20220408
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Amino Acids, Branched-Chain)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Amino Acids, Branched-Chain/metabolism
MH  - Blood Glucose/analysis
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2
MH  - *Dyslipidemias
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - *Insulin Resistance
MH  - Triglycerides
OTO - NOTNLM
OT  - Branched-chain amino acids
OT  - Glycated haemoglobin
OT  - Insulin resistance
OT  - Metabolic dyslipidaemia
OT  - Triglyceride
OT  - Type 2 diabetes mellitus
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/04/16 06:00
MHDA- 2022/05/04 06:00
CRDT- 2022/04/15 20:14
PHST- 2021/10/12 00:00 [received]
PHST- 2022/01/27 00:00 [revised]
PHST- 2022/04/05 00:00 [accepted]
PHST- 2022/04/16 06:00 [pubmed]
PHST- 2022/05/04 06:00 [medline]
PHST- 2022/04/15 20:14 [entrez]
AID - S1871-4021(22)00095-9 [pii]
AID - 10.1016/j.dsx.2022.102481 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2022 Apr;16(4):102481. doi: 10.1016/j.dsx.2022.102481. Epub 
      2022 Apr 8.