PMID- 35428520 OWN - NLM STAT- MEDLINE DCOM- 20220711 LR - 20220715 IS - 1879-1476 (Electronic) IS - 0385-8146 (Linking) VI - 49 IP - 6 DP - 2022 Dec TI - The characteristics of dysphagia and the incidence of pneumonia in Myotonic dystrophy type 1 patients especially concerning swallowing function evaluated by endoscopy. PG - 1003-1008 LID - S0385-8146(22)00099-2 [pii] LID - 10.1016/j.anl.2022.04.003 [doi] AB - OBJECTIVE: The objectives of the study were to clarify the characteristics of dysphagia and the incidence of pneumonia in Myotonic dystrophy type 1 (DM1) patients, and to investigate the relationship between the development of pneumonia and the DM1 patient's background, especially concerning swallowing function evaluated by endoscopy. METHODS: The subjects were 88 DM1 patients who underwent swallowing function evaluation. The severity of disease in DM1patients was assessed based on the muscular impairment rating scale (MIRS), and the number of CTG repeats. Patients were divided into two groups; those who developed aspiration pneumonia within two years after swallowing assessment and those who did not develop aspiration pneumonia. Swallowing function was assessed using the food intake level scale (FILS), repetitive saliva swallowing test (RSST), the modified water swallowing test (MWST), and the Hyodo score. RESULTS: Onset of pneumonia within two years of assessment was observed in 22 cases (25%). Age, FILS, and Hyodo score were significantly different between pneumonia and non-pneumonia groups. There was a significant difference in swallowing function tests such as FILS, RSST, and Hyodo score between males and females. The Hyodo score cutoff value for predicting pneumonia within two years was determined by ROC analysis. A cutoff value of 6 was found to have a sensitivity of 0.545 and a specificity of 0.833 (area under the curve=0.722). CONCLUSION: It is important to evaluate the swallowing function of DM1 patients by endoscopy to prevent aspiration pneumonia. In addition, male patients are more likely to deteriorate in swallowing function and should be carefully monitored. CI - Copyright (c) 2022. Published by Elsevier B.V. FAU - Kambayashi, Tomonori AU - Kambayashi T AD - Department of Otolaryngology and Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan. FAU - Hirano-Kawamoto, Ai AU - Hirano-Kawamoto A AD - Department of Otolaryngology and Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan. FAU - Takahashi, Toshiaki AU - Takahashi T AD - Department of Neurology, National Hospital Organization Sendai-Nishitaga Hospital, Japan. FAU - Taniguchi, Sayaka AU - Taniguchi S AD - Department of Neurology, National Hospital Organization Sendai-Nishitaga Hospital, Japan. FAU - Yoshioka, Masaru AU - Yoshioka M AD - Department of Neurology, National Hospital Organization Sendai-Nishitaga Hospital, Japan. FAU - Tanaka, Hiroyasu AU - Tanaka H AD - Department of Neurology, National Hospital Organization Sendai-Nishitaga Hospital, Japan. FAU - Oizumi, Hideki AU - Oizumi H AD - Department of Neurology, National Hospital Organization Sendai-Nishitaga Hospital, Japan. FAU - Totsune, Tomoko AU - Totsune T AD - Department of Neurology, National Hospital Organization Sendai-Nishitaga Hospital, Japan. FAU - Oshiro, Saki AU - Oshiro S AD - Department of Neurology, National Hospital Organization Sendai-Nishitaga Hospital, Japan. FAU - Baba, Toru AU - Baba T AD - Department of Neurology, National Hospital Organization Sendai-Nishitaga Hospital, Japan. FAU - Takeda, Atsushi AU - Takeda A AD - Department of Neurology, National Hospital Organization Sendai-Nishitaga Hospital, Japan. FAU - Hisaoka, Takuma AU - Hisaoka T AD - Department of Otolaryngology and Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan. FAU - Ohta, Jun AU - Ohta J AD - Department of Otolaryngology and Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan. FAU - Ikeda, Ryoukichi AU - Ikeda R AD - Department of Otolaryngology and Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan. Electronic address: ryoukich@hotmail.com. FAU - Suzuki, Jun AU - Suzuki J AD - Department of Otolaryngology and Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan. FAU - Kato, Kengo AU - Kato K AD - Department of Otolaryngology and Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan. FAU - Katori, Yukio AU - Katori Y AD - Department of Otolaryngology and Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan. LA - eng PT - Journal Article DEP - 20220413 PL - Netherlands TA - Auris Nasus Larynx JT - Auris, nasus, larynx JID - 7708170 SB - IM MH - Case-Control Studies MH - Deglutition/*physiology MH - Deglutition Disorders/complications/diagnosis/*epidemiology MH - Endoscopy, Gastrointestinal MH - Female MH - Humans MH - Incidence MH - Male MH - Myotonic Dystrophy/*complications/epidemiology MH - Pneumonia, Aspiration/complications/*epidemiology/etiology MH - Sensitivity and Specificity OTO - NOTNLM OT - Food intake level Scale OT - Hyodo score OT - Repetitive saliva swallowing test OT - The modified water swallowing test COIS- Declaration of Competing Interest The authors declare no financial relationships or conflict of interest. EDAT- 2022/04/17 06:00 MHDA- 2022/07/12 06:00 CRDT- 2022/04/16 05:19 PHST- 2021/10/31 00:00 [received] PHST- 2022/03/10 00:00 [revised] PHST- 2022/04/04 00:00 [accepted] PHST- 2022/04/17 06:00 [pubmed] PHST- 2022/07/12 06:00 [medline] PHST- 2022/04/16 05:19 [entrez] AID - S0385-8146(22)00099-2 [pii] AID - 10.1016/j.anl.2022.04.003 [doi] PST - ppublish SO - Auris Nasus Larynx. 2022 Dec;49(6):1003-1008. doi: 10.1016/j.anl.2022.04.003. Epub 2022 Apr 13.