PMID- 35429917 OWN - NLM STAT- MEDLINE DCOM- 20220426 LR - 20220624 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 163 DP - 2022 May TI - Do urinary metals associate with the homeostasis of inflammatory mediators? Results from the perspective of inflammatory signaling in middle-aged and older adults. PG - 107237 LID - S0160-4120(22)00163-5 [pii] LID - 10.1016/j.envint.2022.107237 [doi] AB - OBJECTIVE: We aimed to investigate whether urinary metal mixtures are associated with the homeostasis of inflammatory mediators in middle-aged and older adults. METHODS: A four-visit repeated-measures study was conducted with 98 middle-aged and older adults from five communities in Beijing, China. Only one person was lost to follow-up at the third visit. Ultimately, 391 observations were included in the analysis. The urinary concentrations of 10 metals were measured at each visit using inductively coupled plasma mass spectrometry (ICP-MS) with a limit of detection (LOD) ranging from 0.002 to 0.173 microg/L, and the detection rates were all above 84%. Similarly, 14 serum inflammatory mediators were measured using a Beckman Coulter analyzer and the Bio-Plex MAGPIX system. A linear mixed model (LMM), LMM with least absolute shrinkage and selection operator regularization (LMMLASSO), and Bayesian kernel machine regression (BKMR) were adopted to explore the effects of urinary metal mixtures on inflammatory mediators. RESULTS: In LMM, a two-fold increase in urinary cesium (Cs) and chromium (Cr) was statistically associated with -35.22% (95% confidence interval [CI]: -53.17, -10.40) changes in interleukin 6 (IL-6) and -11.13% (95 %CI: -20.67, -0.44) in IL-8. Urinary copper (Cu) and selenium (Se) was statistically associated with IL-6 (88.10%, 95%CI: 34.92, 162.24) and tumor necrosis factor-alpha (TNF-alpha) (22.32%, 95%CI: 3.28, 44.12), respectively. Similar results were observed for the LMMLASSO and BKMR. Furthermore, Cr, Cs, Cu, and Se were significantly associated with other inflammatory regulatory network mediators. For example, urinary Cs was statistically associated with endothelin-1, and Cr was statistically associated with endothelin-1 and intercellular adhesion molecule 1 (ICAM-1). Finally, the interaction effects of Cu with various metals on inflammatory mediators were observed. CONCLUSION: Our findings suggest that Cr, Cs, Cu, and Se may disrupt the homeostasis of inflammatory mediators, providing insight into the potential pathophysiological mechanisms of metal mixtures and chronic diseases. CI - Copyright (c) 2022. Published by Elsevier Ltd. FAU - Li, Ang AU - Li A AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China. FAU - Mei, Yayuan AU - Mei Y AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China. FAU - Zhao, Meiduo AU - Zhao M AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China. FAU - Xu, Jing AU - Xu J AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China. FAU - Zhao, Jiaxin AU - Zhao J AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China. FAU - Zhou, Quan AU - Zhou Q AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China. FAU - Ge, Xiaoyu AU - Ge X AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China. FAU - Xu, Qun AU - Xu Q AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China. Electronic address: xuqun@ibms.cams.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220409 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Endothelin-1) RN - 0 (Inflammation Mediators) RN - 0 (Interleukin-6) RN - 0 (Metals) RN - 0R0008Q3JB (Chromium) RN - H6241UJ22B (Selenium) SB - IM MH - Aged MH - Bayes Theorem MH - Chromium MH - Endothelin-1 MH - Homeostasis MH - Humans MH - *Inflammation Mediators MH - Interleukin-6 MH - Metals/toxicity MH - Middle Aged MH - *Selenium OTO - NOTNLM OT - Bayesian kernel machine regression OT - Mediator homeostasis OT - Middle-aged and older adults OT - Repeated measurement OT - Urinary metal mixtures EDAT- 2022/04/17 06:00 MHDA- 2022/04/27 06:00 CRDT- 2022/04/16 20:15 PHST- 2021/08/06 00:00 [received] PHST- 2022/03/30 00:00 [revised] PHST- 2022/04/07 00:00 [accepted] PHST- 2022/04/17 06:00 [pubmed] PHST- 2022/04/27 06:00 [medline] PHST- 2022/04/16 20:15 [entrez] AID - S0160-4120(22)00163-5 [pii] AID - 10.1016/j.envint.2022.107237 [doi] PST - ppublish SO - Environ Int. 2022 May;163:107237. doi: 10.1016/j.envint.2022.107237. Epub 2022 Apr 9.