PMID- 35430166
OWN - NLM
STAT- MEDLINE
DCOM- 20220614
LR  - 20220724
IS  - 1532-8392 (Electronic)
IS  - 0046-8177 (Linking)
VI  - 125
DP  - 2022 Jul
TI  - Unique membranous gastrin receptor expression of parietal cells and its 
      distribution pattern in the gastric oxyntic mucosa and fundic gland polyps.
PG  - 23-34
LID - S0046-8177(22)00080-6 [pii]
LID - 10.1016/j.humpath.2022.04.001 [doi]
AB  - The aim of this study was to clarify the correlation between gastrin receptor 
      (GR) expression in the gastric oxyntic mucosa and fundic gland polyps (FGPs) and 
      the histological and immunohistochemical findings of the mucosa as well as the 
      history of proton pump inhibitor (PPI) administration. The unique membranous 
      linear positivity of GR in parietal cells was reproducibly observed by 
      immunohistochemistry, which was also validated by immunofluorescence. Further 
      histological and immunohistochemical examination of 34 oxyntic mucosae and 43 
      FGPs revealed the following: 1) parietal cells (PCs) with membranous linear GR 
      expression (mGR) were observed to be limited to the isthmus-neck region in the 
      normal state; 2) appearance of PCs with mGR in the deep oxyntic gland regions was 
      significantly related to the PPI medication history; 3) PCs with mGR were more 
      frequently observed in the deep oxyntic gland regions when the oxyntic mucosa 
      showed derangement of mucosal component cell compartmentalization revealed by 
      MUC5AC and MUC6 immunohistochemistry, which was also significantly related to the 
      PPI use; and 4) PCs with intense membranous linear positivity of GR were observed 
      to be diffusely distributed in all of the cases of FGPs. In conclusion, the 
      distribution of unique GR membranous linear expression in PCs of the oxyntic 
      mucosa under PPI medication and FGPs could reflect the pathologic mucosal state 
      characterized by derangement of the compartmentalization of mucosal component 
      cells, which could be another basis for evaluating physiologic and/or 
      pathophysiologic conditions of the gastric mucosa.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Sato, Yoko
AU  - Sato Y
AD  - Department of Pathology, Dokkyo Medical University Saitama Medical Center, 2-1-50 
      Minami-Koshigaya, Koshigaya, Saitama 343-8555, Japan. Electronic address: 
      yokosato@dokkyomed.ac.jp.
FAU - Ban, Shinichi
AU  - Ban S
AD  - Department of Pathology, Dokkyo Medical University Saitama Medical Center, 2-1-50 
      Minami-Koshigaya, Koshigaya, Saitama 343-8555, Japan. Electronic address: 
      shinba@dokkyomed.ac.jp.
FAU - Katayama, Yasumi
AU  - Katayama Y
AD  - Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, 
      2-1-50 Minami-Koshigaya, Koshigaya, Saitama 343-8555, Japan. Electronic address: 
      yasumi@dokkyomed.ac.jp.
FAU - Mitsui, Takashi
AU  - Mitsui T
AD  - Department of Surgery, Dokkyo Medical University Saitama Medical Center, 2-1-50 
      Minami-Koshigaya, Koshigaya, Saitama 343-8555, Japan. Electronic address: 
      mitsui@dokkyomed.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20220414
PL  - United States
TA  - Hum Pathol
JT  - Human pathology
JID - 9421547
RN  - 0 (Gastrins)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Receptor, Cholecystokinin B)
RN  - Polyposis Of Gastric Fundus Without Polyposis Coli
RN  - Polyposis, Gastric
SB  - IM
MH  - Adenomatous Polyps
MH  - Gastric Mucosa/pathology
MH  - Gastrins
MH  - Humans
MH  - Parietal Cells, Gastric/pathology
MH  - *Polyps/pathology
MH  - Proton Pump Inhibitors
MH  - *Receptor, Cholecystokinin B/metabolism
MH  - *Stomach Neoplasms/pathology
OTO - NOTNLM
OT  - Fundic gland polyp
OT  - Gastrin receptor
OT  - Immunohistochemistry
OT  - Oxyntic mucosa
OT  - Proton pump inhibitor
EDAT- 2022/04/18 06:00
MHDA- 2022/06/15 06:00
CRDT- 2022/04/17 20:17
PHST- 2021/12/31 00:00 [received]
PHST- 2022/04/03 00:00 [revised]
PHST- 2022/04/04 00:00 [accepted]
PHST- 2022/04/18 06:00 [pubmed]
PHST- 2022/06/15 06:00 [medline]
PHST- 2022/04/17 20:17 [entrez]
AID - S0046-8177(22)00080-6 [pii]
AID - 10.1016/j.humpath.2022.04.001 [doi]
PST - ppublish
SO  - Hum Pathol. 2022 Jul;125:23-34. doi: 10.1016/j.humpath.2022.04.001. Epub 2022 Apr 
      14.