PMID- 3543146
OWN - NLM
STAT- MEDLINE
DCOM- 19870311
LR  - 20190510
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 155
IP  - 2
DP  - 1987 Feb
TI  - Parenteral chloroquine for treating falciparum malaria.
PG  - 192-201
AB  - There is no information and therefore no consensus on how chloroquine should be 
      administered to persons with severe malaria. Although widely considered 
      dangerous, parenteral chloroquine is extensively used. We studied the acute 
      disposition and toxicity of intravenous (iv), intramuscular (im), subcutaneous 
      (sc), and oral chloroquine in 60 adult Zambian patients hospitalized with 
      falciparum malaria. Plasma concentration profiles after parenteral administration 
      were characterized by wide fluctuations between peak and trough values. 
      Absorption of im and sc chloroquine was rapid, with a median time to peak 
      concentration of 30 min and a peak plasma concentration five times higher than 
      after oral administration. The pharmacokinetic data suggest that the acute 
      toxicity of parenteral chloroquine is related to transiently high concentrations 
      in blood and result from incomplete distribution out of a relatively small 
      central compartment. Parenteral chloroquine may be administered safely by simply 
      giving smaller, more-frequent doses than are currently used or, in the case of iv 
      administration, by using continuous infusion.
FAU - White, N J
AU  - White NJ
FAU - Watt, G
AU  - Watt G
FAU - Bergqvist, Y
AU  - Bergqvist Y
FAU - Njelesani, E K
AU  - Njelesani EK
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 886U3H6UFF (Chloroquine)
SB  - IM
MH  - Administration, Oral
MH  - Adolescent
MH  - Adult
MH  - Brain Diseases/drug therapy/etiology
MH  - Chloroquine/*administration & dosage/adverse effects/metabolism/therapeutic use
MH  - Female
MH  - Humans
MH  - Infusions, Intravenous
MH  - Injections, Intramuscular
MH  - Injections, Subcutaneous
MH  - Kinetics
MH  - Malaria/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Plasmodium falciparum
EDAT- 1987/02/01 00:00
MHDA- 1987/02/01 00:01
CRDT- 1987/02/01 00:00
PHST- 1987/02/01 00:00 [pubmed]
PHST- 1987/02/01 00:01 [medline]
PHST- 1987/02/01 00:00 [entrez]
AID - 10.1093/infdis/155.2.192 [doi]
PST - ppublish
SO  - J Infect Dis. 1987 Feb;155(2):192-201. doi: 10.1093/infdis/155.2.192.