PMID- 35431594
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1319-562X (Print)
IS  - 2213-7106 (Electronic)
IS  - 2213-7106 (Linking)
VI  - 29
IP  - 6
DP  - 2022 Jun
TI  - Endotoxemia, vitamin D and premature biological ageing in Arab adults with 
      different metabolic states.
PG  - 103276
LID - 10.1016/j.sjbs.2022.03.026 [doi]
LID - 103276
AB  - There are limited studies on the association of endotoxin, a potent mediator of 
      gut-derived inflammation and telomere length (TL). We investigated (1) the 
      influence of adiposity on endotoxin and TL amongst Saudi adults according to type 
      2 diabetes mellitus (T2DM) status and (2) the influence vitamin D may have on TL 
      attrition. Anthropometric data and fasting blood samples were taken from 775 
      Saudi adults visiting different primary care centers in Riyadh [387 T2DM and 388 
      non-T2DM]. TL, derived from peripheral blood mononuclear cells, was analyzed by 
      Quantitative real-time polymerase chain reaction and circulating endotoxin levels 
      by Limulus Amebocyte Lysate assay. Subjects were stratified based on obesity and 
      T2DM status. A significant lower TL was observed in the non-obese T2DM group as 
      compared with their non-obese, non-T2DM counterparts (p = 0.002). Significant 
      inverse associations between TL, endotoxin and endotoxin activity were observed 
      in the cohort with obesity. Regression analysis showed that endotoxin was a 
      significant predictor for TL in all subjects and even after stratification 
      according to subgroups; with variances perceived in circulating TL stronger among 
      non-T2DM obese (10%; p = 0.003) than non-T2DM non-obese (12%; p = 0.007). Also, 
      in the non-T2DM group, TL and HDL-cholesterol predicted 29% of the variances 
      perceived in 25(OH)D (p < 0.001). Taken together these findings show that 
      circulating endotoxin and 25(OH)D are associated with premature biological ageing 
      influenced by adiposity and metabolic state; suggesting future intervention 
      studies to manipulate gut microbiome and or vitamin D levels may offer ways to 
      mitigate premature TL attrition.
CI  - (c) 2022 The Author(s).
FAU - Al-Daghri, Nasser M
AU  - Al-Daghri NM
AD  - Biochemistry Department, Chair for Biomarkers of Chronic Diseases, King Saud 
      University, Riyadh 11451, Saudi Arabia.
FAU - Sabico, Shaun
AU  - Sabico S
AD  - Biochemistry Department, Chair for Biomarkers of Chronic Diseases, King Saud 
      University, Riyadh 11451, Saudi Arabia.
FAU - Ansari, Mohammed G A
AU  - Ansari MGA
AD  - Biochemistry Department, Chair for Biomarkers of Chronic Diseases, King Saud 
      University, Riyadh 11451, Saudi Arabia.
FAU - Abdi, Saba
AU  - Abdi S
AD  - Biochemistry Department, Chair for Biomarkers of Chronic Diseases, King Saud 
      University, Riyadh 11451, Saudi Arabia.
FAU - Tripathi, Gyanendra
AU  - Tripathi G
AD  - Human Sciences Research Centre, School of Human Sciences, University of Derby, 
      Derby, DE122 1GB, UK.
FAU - Chrousos, George P
AU  - Chrousos GP
AD  - University Research Institute of Maternal and Child Health and Precision 
      Medicine, UNESCO Chair on Adolescent Health Care, National and Kapodistrian 
      University of Athens, 11527 Athens, Greece, Greece.
FAU - McTernan, Philip G
AU  - McTernan PG
AD  - Department of Biosciences, School of Science and Technology, Nottingham Trent 
      University, Nottingham, NG1 8NS, UK.
LA  - eng
PT  - Journal Article
DEP - 20220331
PL  - Saudi Arabia
TA  - Saudi J Biol Sci
JT  - Saudi journal of biological sciences
JID - 101543796
PMC - PMC9011112
OTO - NOTNLM
OT  - Age
OT  - Endotoxin
OT  - Endotoxin/HDL-Cholesterol ratio
OT  - Oxidative stress
OT  - Systemic inflammation
OT  - Telomere length
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2022/04/19 06:00
MHDA- 2022/04/19 06:01
PMCR- 2022/03/31
CRDT- 2022/04/18 06:31
PHST- 2022/02/08 00:00 [received]
PHST- 2022/02/15 00:00 [revised]
PHST- 2022/03/19 00:00 [accepted]
PHST- 2022/04/18 06:31 [entrez]
PHST- 2022/04/19 06:00 [pubmed]
PHST- 2022/04/19 06:01 [medline]
PHST- 2022/03/31 00:00 [pmc-release]
AID - S1319-562X(22)00184-X [pii]
AID - 103276 [pii]
AID - 10.1016/j.sjbs.2022.03.026 [doi]
PST - ppublish
SO  - Saudi J Biol Sci. 2022 Jun;29(6):103276. doi: 10.1016/j.sjbs.2022.03.026. Epub 
      2022 Mar 31.