PMID- 35431890
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 14
DP  - 2022
TI  - Resting-State Functional Network Topology Alterations of the Occipital Lobe 
      Associated With Attention Impairment in Isolated Rapid Eye Movement Behavior 
      Disorder.
PG  - 844483
LID - 10.3389/fnagi.2022.844483 [doi]
LID - 844483
AB  - PURPOSE: This study investigates the topological properties of brain functional 
      networks in patients with isolated rapid eye movement sleep behavior disorder 
      (iRBD). PARTICIPANTS AND METHODS: A total of 21 patients with iRBD (iRBD group) 
      and 22 healthy controls (HCs) were evaluated using resting-state functional MRI 
      (rs-fMRI) and neuropsychological measures in cognitive and motor function. Data 
      from rs-fMRI were analyzed using graph theory, which included small-world 
      properties, network efficiency, network local efficiency, nodal shortest path, 
      node efficiency, and network connectivity, as well as the relationship between 
      behavioral characteristics and altered brain topological features. RESULTS: 
      Rey-Osterrieth complex figure test (ROCFT-copy), symbol digital modalities test 
      (SDMT), auditory verbal learning test (AVLT)-N1, AVLT-N2, AVLT-N3, and AVLT-N1-3 
      scores were significantly lower in patients with iRBD than in HC (P < 0.05), 
      while trail making test A (TMT-A), TMT-B, and Unified Parkinson's Disease Rating 
      Scale Part-III (UPDRS-III) scores were higher in patients with iRBD (P < 0.05). 
      Compared with the HCs, patients with iRBD had no difference in the small-world 
      attributes (P > 0.05). However, there was a significant decrease in network 
      global efficiency (P = 0.0052) and network local efficiency (P = 0.0146), while 
      an increase in characteristic path length (P = 0.0071). There was lower nodal 
      efficiency in occipital gyrus and nodal shortest path in frontal, parietal, 
      temporal lobe, and cingulate gyrus. Functional connectivities were decreased 
      between the nodes of occipital with the regions where they had declined nodal 
      shortest path. There was a positive correlation between TMT-A scores and the 
      nodal efficiency of the right middle occipital gyrus (R = 0.602, P = 0.014). 
      CONCLUSION: These results suggest that abnormal behaviors may be associated with 
      disrupted brain network topology and functional connectivity in patients with 
      iRBD and also provide novel insights to understand pathophysiological mechanisms 
      in iRBD.
CI  - Copyright (c) 2022 Geng, Wang, Li, Xu, Bai, Zhou, Zhang, Li, Zhang and Zhang.
FAU - Geng, Chaofan
AU  - Geng C
AD  - Henan University People's Hospital, Henan Provincial People's Hospital, 
      Zhengzhou, China.
FAU - Wang, Shenghui
AU  - Wang S
AD  - Department of Neurology, Zhengzhou University People's Hospital, Henan Provincial 
      People's Hospital, Zhengzhou, China.
FAU - Li, Zhonglin
AU  - Li Z
AD  - Department of Radiology, Zhengzhou University People's Hospital, Zhengzhou, 
      China.
FAU - Xu, Pengfei
AU  - Xu P
AD  - Henan University People's Hospital, Henan Provincial People's Hospital, 
      Zhengzhou, China.
FAU - Bai, Yingying
AU  - Bai Y
AD  - Department of Neurology, Zhengzhou University People's Hospital, Henan Provincial 
      People's Hospital, Zhengzhou, China.
FAU - Zhou, Yao
AU  - Zhou Y
AD  - Department of Neurology, Zhengzhou University People's Hospital, Henan Provincial 
      People's Hospital, Zhengzhou, China.
FAU - Zhang, Xinyu
AU  - Zhang X
AD  - Department of Neurology, Henan Provincial People's Hospital Affiliated to 
      Xinxiang Medical University, Zhengzhou, China.
FAU - Li, Yongli
AU  - Li Y
AD  - Department of Functional Imaging, Henan Key Laboratory for Medical Imaging of 
      Neurological Diseases, Zhengzhou, China.
FAU - Zhang, Jiewen
AU  - Zhang J
AD  - Department of Neurology, Zhengzhou University People's Hospital, Henan Provincial 
      People's Hospital, Zhengzhou, China.
FAU - Zhang, Hongju
AU  - Zhang H
AD  - Henan University People's Hospital, Henan Provincial People's Hospital, 
      Zhengzhou, China.
AD  - Department of Neurology, Zhengzhou University People's Hospital, Henan Provincial 
      People's Hospital, Zhengzhou, China.
AD  - Department of Neurology, Henan Provincial People's Hospital Affiliated to 
      Xinxiang Medical University, Zhengzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20220401
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC9012114
OTO - NOTNLM
OT  - functional disorders
OT  - graph theory
OT  - idiopathic rapid eye movement sleep behavior disorder
OT  - network topology
OT  - resting-state functional magnetic resonance imaging
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/04/19 06:00
MHDA- 2022/04/19 06:01
PMCR- 2022/01/01
CRDT- 2022/04/18 06:32
PHST- 2021/12/28 00:00 [received]
PHST- 2022/02/11 00:00 [accepted]
PHST- 2022/04/18 06:32 [entrez]
PHST- 2022/04/19 06:00 [pubmed]
PHST- 2022/04/19 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2022.844483 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2022 Apr 1;14:844483. doi: 10.3389/fnagi.2022.844483. 
      eCollection 2022.