PMID- 35432291
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220512
IS  - 1664-302X (Print)
IS  - 1664-302X (Electronic)
IS  - 1664-302X (Linking)
VI  - 13
DP  - 2022
TI  - Observation of the Gut Microbiota Profile in BALB/c Mice Induced by Plasmodium 
      yoelii 17XL Infection.
PG  - 858897
LID - 10.3389/fmicb.2022.858897 [doi]
LID - 858897
AB  - Rodent malaria caused by Plasmodium yoelii 17XL (Py 17XL) is an ideal animal 
      model for human malaria studies. Although the gut microbiota plays an important 
      role in the occurrence and development of infectious diseases, the gut microbiota 
      associated with Py 17XL infection remains unclear. In the current study, the gut 
      microbiota composition of infected BALB/c mice was surveyed. Mouse fecal samples 
      were collected at 0, 2, 5 days post-infection (dpi), and the gut microbiota was 
      characterized by 16S rRNA sequencing. Operational taxonomic units (OTUs) were 634 
      +/- 26 on average. Firmicutes and Bacteroidetes were typically predominant in the 
      gut microbiota composition at the phylum level. Compared with the Ctrl, 
      Firmicutes was significantly decreased after infection, while Bacteroidetes was 
      notably increased. The most dominant family was Lactobacillaceae in all samples. 
      The alpha diversity index showed that compared with that of the Ctrl, the 
      observed OTU number was decreased at 2 dpi and then slightly increased at 5 dpi. 
      LEfSe analysis revealed several bacterial taxa were notably related to 
      Py-infected mice at the phylogenetic level. Several bacterial genera, such as 
      Lactobacillus, were overrepresented in the Py-infected fecal microbiota at 2 dpi, 
      while Muribaculaceae was overrepresented at 5 dpi. Moreover, Alistipes and 
      Helicobacter were overrepresented at 5 dpi compared with 2 dpi. The results 
      indicated Py infection could alter the gut microbiota composition of mice. 
      Besides, biomarkers could serve as direct targets to elucidate their roles in the 
      progression and pathogenesis of malaria and provide insights into studies of 
      antimalarial drugs and malaria vaccines.
CI  - Copyright (c) 2022 Guan, Song, Yang, Zhu, Li and Li.
FAU - Guan, Wei
AU  - Guan W
AD  - Department of Human Parasitology, School of Basic Medicine Science, Hubei 
      University of Medicine, Shiyan, China.
FAU - Song, Xiaonan
AU  - Song X
AD  - Department of Human Parasitology, School of Basic Medicine Science, Hubei 
      University of Medicine, Shiyan, China.
FAU - Yang, Shuguo
AU  - Yang S
AD  - Department of Human Parasitology, School of Basic Medicine Science, Hubei 
      University of Medicine, Shiyan, China.
FAU - Zhu, Huiyin
AU  - Zhu H
AD  - Department of Human Parasitology, School of Basic Medicine Science, Hubei 
      University of Medicine, Shiyan, China.
FAU - Li, Fang
AU  - Li F
AD  - Department of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, 
      Shiyan, China.
FAU - Li, Jian
AU  - Li J
AD  - Department of Human Parasitology, School of Basic Medicine Science, Hubei 
      University of Medicine, Shiyan, China.
LA  - eng
PT  - Journal Article
DEP - 20220331
PL  - Switzerland
TA  - Front Microbiol
JT  - Frontiers in microbiology
JID - 101548977
PMC - PMC9009211
OTO - NOTNLM
OT  - 16S rRNA
OT  - Plasmodium yoelii
OT  - biomarker
OT  - gut microbiota
OT  - malaria
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/04/19 06:00
MHDA- 2022/04/19 06:01
PMCR- 2022/03/31
CRDT- 2022/04/18 06:33
PHST- 2022/01/20 00:00 [received]
PHST- 2022/02/22 00:00 [accepted]
PHST- 2022/04/18 06:33 [entrez]
PHST- 2022/04/19 06:00 [pubmed]
PHST- 2022/04/19 06:01 [medline]
PHST- 2022/03/31 00:00 [pmc-release]
AID - 10.3389/fmicb.2022.858897 [doi]
PST - epublish
SO  - Front Microbiol. 2022 Mar 31;13:858897. doi: 10.3389/fmicb.2022.858897. 
      eCollection 2022.