PMID- 35432407
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230306
IS  - 1664-462X (Print)
IS  - 1664-462X (Electronic)
IS  - 1664-462X (Linking)
VI  - 13
DP  - 2022
TI  - Phytochromes A and B Mediate Light Stabilization of BIN2 to Regulate 
      Brassinosteroid Signaling and Photomorphogenesis in Arabidopsis.
PG  - 865019
LID - 10.3389/fpls.2022.865019 [doi]
LID - 865019
AB  - Phytochromes A and B (phyA and phyB) are the far-red and red lights 
      photoreceptors mediating many light responses in Arabidopsis thaliana. 
      Brassinosteroid (BR) is a pivotal phytohormone regulating a variety of plant 
      developmental processes including photomorphogenesis. It is known that phyB 
      interacts with BES1 to inhibit its DNA-binding activity and repress BR signaling. 
      Here, we show that far-red and red lights modulate BR signaling through phyA and 
      phyB regulation of the stability of BIN2, a glycogen synthase kinase 3 
      (GSK3)-like kinase that phosphorylates BES1/BZR1 to inhibit BR signaling. The 
      BIN2 gain-of-function mutant bin2-1 displays an enhanced photomorphogenic 
      phenotype in both far-red and red lights. phyA-enhanced accumulation of BIN2 
      promotes the phosphorylation of BES1 in far-red light. BIN2 acts genetically 
      downstream from PHYA to regulate photomorphogenesis under far-red light. Both 
      phyA and phyB interact directly with BIN2, which may promote the interaction of 
      BIN2 with BES1 and induce the phosphorylation of BES1. Our results suggest that 
      far-red and red lights inhibit BR signaling through phyA and phyB stabilization 
      of BIN2 and promotion of BES1 phosphorylation, which defines a new layer of the 
      regulatory mechanism that allows plants to coordinate light and BR signaling 
      pathways to optimize photomorphogenesis.
CI  - Copyright (c) 2022 Zhao, Yang, Jiang, Zhang, Miao, Xu, Chen, Chen, Mao, Guo, Kou, 
      Yang and Wang.
FAU - Zhao, Jiachen
AU  - Zhao J
AD  - Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, 
      Shanghai Normal University, Shanghai, China.
FAU - Yang, Guangqiong
AU  - Yang G
AD  - Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, 
      Shanghai Normal University, Shanghai, China.
FAU - Jiang, Lu
AU  - Jiang L
AD  - Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, 
      Shanghai Normal University, Shanghai, China.
FAU - Zhang, Shilong
AU  - Zhang S
AD  - Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, 
      Shanghai Normal University, Shanghai, China.
FAU - Miao, Langxi
AU  - Miao L
AD  - School of Life Sciences, Fudan University, Shanghai, China.
FAU - Xu, Peng
AU  - Xu P
AD  - School of Life Sciences, Fudan University, Shanghai, China.
FAU - Chen, Huiru
AU  - Chen H
AD  - Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, 
      Shanghai Normal University, Shanghai, China.
FAU - Chen, Li
AU  - Chen L
AD  - Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, 
      Shanghai Normal University, Shanghai, China.
FAU - Mao, Zhilei
AU  - Mao Z
AD  - Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, 
      Shanghai Normal University, Shanghai, China.
FAU - Guo, Tongtong
AU  - Guo T
AD  - Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, 
      Shanghai Normal University, Shanghai, China.
FAU - Kou, Shuang
AU  - Kou S
AD  - Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, 
      Shanghai Normal University, Shanghai, China.
FAU - Yang, Hong-Quan
AU  - Yang HQ
AD  - Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, 
      Shanghai Normal University, Shanghai, China.
FAU - Wang, Wenxiu
AU  - Wang W
AD  - Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, 
      Shanghai Normal University, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20220330
PL  - Switzerland
TA  - Front Plant Sci
JT  - Frontiers in plant science
JID - 101568200
EIN - Front Plant Sci. 2023 Feb 17;13:1118271. PMID: 36874913
PMC - PMC9005995
OTO - NOTNLM
OT  - Arabidopsis
OT  - BRASSINOSTEROID-INSENSITIVE 2 (BIN2)
OT  - BRI1-EMS SUPPRESSOR 1 (BES1)
OT  - brassinosteroid (BR)
OT  - photomorphogenesis
OT  - phytochrome A (phyA)
OT  - phytochrome B (phyB)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/04/19 06:00
MHDA- 2022/04/19 06:01
PMCR- 2022/01/01
CRDT- 2022/04/18 06:34
PHST- 2022/01/29 00:00 [received]
PHST- 2022/03/07 00:00 [accepted]
PHST- 2022/04/18 06:34 [entrez]
PHST- 2022/04/19 06:00 [pubmed]
PHST- 2022/04/19 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fpls.2022.865019 [doi]
PST - epublish
SO  - Front Plant Sci. 2022 Mar 30;13:865019. doi: 10.3389/fpls.2022.865019. 
      eCollection 2022.