PMID- 35432712
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220419
IS  - 1939-4551 (Print)
IS  - 1939-4551 (Electronic)
IS  - 1939-4551 (Linking)
VI  - 15
IP  - 4
DP  - 2022 Apr
TI  - Cord blood 25(OH)D(3), cord blood total immunoglobulin E levels, and food 
      allergies in infancy: A birth cohort study in Chongqing, China.
PG  - 100645
LID - 10.1016/j.waojou.2022.100645 [doi]
LID - 100645
AB  - BACKGROUND: Food allergy (FA) in infants has become a common disease worldwide. 
      There are many controversies surrounding the relationships among levels of cord 
      blood 25-hydroxy vitamin D(3) [25(OH)D(3)], total immunoglobulin E (IgE), and FA. 
      METHODS: In this study, we recruited pregnant women in the third trimester 
      undergoing obstetric examination in Chongqing City, Western China. Healthy 
      full-term singleton births between May to August 2018 and November 2018 to 
      January 2019 were included in the summer-birth and winter-birth cohorts, 
      respectively. Questionnaires on vitamin D status in pregnancy and family 
      allergies were used to investigate the pregnant women. The levels of <12 ng/mL, 
      12～20 ng/mL, and >20 ng/mL 25(OH)D(3) in cord blood detected by liquid 
      chromatography tandem mass spectrometry were considered deficient, insufficient, 
      and sufficient, respectively. The electrochemiluminescence method was used to 
      detect the total lgE levels in cord blood, classified into low-IgE (<0.35 IU/mL) 
      and high-IgE (>/=0.35 IU/mL) levels, respectively. Within postnatal 6 months, 
      allergic symptoms in infants were investigated using questionnaire during the 
      infants' monthly physical examinations. Suspected cases of FA underwent a history 
      inquiry, skin prick test, food elimination test, and open-food challenge for 
      diagnosis of FA. Multivariate logistic regression was used to analyze the risk 
      factors of FA in infants. RESULTS: In this study, we recruited 741 pairs of 
      pregnant women and infants, including 343 infants in the summer-birth cohort and 
      398 infants in the winter-birth cohort. The incidence of FA within postnatal 6 
      months was 6.88%, showing significantly higher incidence of FA in the 
      winter-birth cohorts than in the summer-birth cohorts (10.3% vs. 2.9%, 
      chi2 = 15.682, P = 0.000). Among the 741 infants, 47.1%, 27.5%, and 13.8% of 
      infants had deficient, insufficient, and sufficient 25(OH)D(3), respectively, in 
      the cord blood; 81.5% and 18.5% of infants had total low-IgE and total high-IgE 
      levels, respectively, in the cord blood. No significant correlation was found 
      between the 25(OH)D(3) and IgE levels (r = -0.038, P = 0.300). Logistic 
      regression analysis showed that winter birth [odds ratio (OR) 95% confidence 
      interval (CI): 4.292 (2.003～8.359)] compared with infants in summer birth group, 
      and sufficient (>20 ng/mL) 25(OH)D(3) levels in cord blood [OR (95% CI): 2.355 
      (1.129～4.911) compared with infants in the deficient group (<12 ng/mL) and 3.782 
      (1.680～8.514) compared with infants in the insufficient group (12～20 ng/mL)] were 
      independent risk factors for FA in infants within postnatal 6 months. 
      CONCLUSIONS: Winter birth and sufficient 25(OH)D(3) levels in infant cord blood 
      were independent risk factors for FA in infants. 25(OH)D(3) and total IgE levels 
      in cord blood cannot be used as predictors of FA in early infancy.
CI  - (c) 2022 The Authors.
FAU - Wang, Nian-Rong
AU  - Wang NR
AD  - Department of Children Healthcare, Chongqing Health Center for Women and 
      Children, 120 Longshan Road, Yubei District, Chongqing, 400021, PR China.
FAU - Liu, Shi-Jian
AU  - Liu SJ
AD  - Department of Clinical Epidemiology and Biostatistics, Children Health Advocacy 
      Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University 
      School of Medicine, 1678 Dongfang Road, Pudong New District, Shanghai, 200127, PR 
      China.
FAU - Xiao, Gui-Yuan
AU  - Xiao GY
AD  - Department of Children Healthcare, Chongqing Health Center for Women and 
      Children, 120 Longshan Road, Yubei District, Chongqing, 400021, PR China.
FAU - Zhang, Hua
AU  - Zhang H
AD  - Department of Children Healthcare, Chongqing Health Center for Women and 
      Children, 120 Longshan Road, Yubei District, Chongqing, 400021, PR China.
FAU - Huang, Yu-Jie
AU  - Huang YJ
AD  - Department of Children Healthcare, Chongqing Health Center for Women and 
      Children, 120 Longshan Road, Yubei District, Chongqing, 400021, PR China.
FAU - Wang, Li
AU  - Wang L
AD  - Department of Children Healthcare, Chongqing Health Center for Women and 
      Children, 120 Longshan Road, Yubei District, Chongqing, 400021, PR China.
FAU - He, Chun-Yan
AU  - He CY
AD  - Department of Children Healthcare, Chongqing Health Center for Women and 
      Children, 120 Longshan Road, Yubei District, Chongqing, 400021, PR China.
LA  - eng
PT  - Journal Article
DEP - 20220401
PL  - United States
TA  - World Allergy Organ J
JT  - The World Allergy Organization journal
JID - 101481283
PMC - PMC8980958
OTO - NOTNLM
OT  - 25-Hydroxy vitamin D3
OT  - Cord blood
OT  - Food allergy
OT  - Immunoglobulin E
EDAT- 2022/04/19 06:00
MHDA- 2022/04/19 06:01
PMCR- 2022/04/01
CRDT- 2022/04/18 06:35
PHST- 2021/05/07 00:00 [received]
PHST- 2022/03/10 00:00 [revised]
PHST- 2022/03/14 00:00 [accepted]
PHST- 2022/04/18 06:35 [entrez]
PHST- 2022/04/19 06:00 [pubmed]
PHST- 2022/04/19 06:01 [medline]
PHST- 2022/04/01 00:00 [pmc-release]
AID - S1939-4551(22)00021-7 [pii]
AID - 100645 [pii]
AID - 10.1016/j.waojou.2022.100645 [doi]
PST - epublish
SO  - World Allergy Organ J. 2022 Apr 1;15(4):100645. doi: 
      10.1016/j.waojou.2022.100645. eCollection 2022 Apr.