PMID- 35432804
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220419
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 24
IP  - 12
DP  - 2021 Dec
TI  - Voluntary exercise could reduce sperm malformations by improving 
      hypothalamus-hypophysis-gonadal axis and kisspeptin/leptin signaling in type 2 
      diabetic rats.
PG  - 1624-1631
LID - 10.22038/IJBMS.2021.58740.13048 [doi]
AB  - OBJECTIVES: Most male patients with type 2 diabetes mellitus (T2DM) experience 
      infertility. It is well established that regular physical activity could 
      alleviate diabetic infertility symptoms. This study was designed to determine the 
      effect of voluntary exercise on sperm malformation. MATERIALS AND METHODS: 
      Thirty-two male Wistar rats were randomly divided into control (C), diabetic (D), 
      voluntary exercise (Ex), and diabetic-voluntary exercise (D-Ex) groups. Diabetes 
      was induced by an intraperitoneal injection of streptozotocin (35 mg/kg) followed 
      by a high-fat diet for four weeks. Voluntary exercise was performed by placing 
      the animals in the rotary wheel cages for ten weeks. Sperm malformations were 
      analyzed. Moreover, the hypothalamic leptin, kisspeptin, kisspeptin receptors 
      (KissR), as well as plasma LH, FSH, testosterone, and leptin levels were 
      evaluated. RESULTS: Results showed that induction of T2DM caused increased sperm 
      malformation, plasma, and hypothalamic leptin as well as decreased hypothalamic 
      kisspeptin, KissR, and plasma LH levels compared with the C group (P<0.001 to 
      P<0.01). Voluntary exercise in the Ex group increased hypothalamic KissR, plasma 
      FSH, LH, and testosterone levels compared with the C group; however, it decreased 
      sperm malformation and hypothalamic leptin levels (P<0.001 to P<0.05). Voluntary 
      exercise in the D-Ex group reduced sperm malformation, hypothalamic leptin, and 
      plasma testosterone while elevated hypothalamic kisspeptin and KissR protein 
      levels compared with the D group (P<0.001 to P<0.01). CONCLUSION: The results 
      illustrated voluntary exercise reduces sperm malformations by improving the HHG 
      axis and kisspeptin/leptin signaling in rats with T2DM.
FAU - Kharazi, Uldouz
AU  - Kharazi U
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
AD  - Department of Physiology, Faculty of Medicine, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Keyhanmanesh, Rana
AU  - Keyhanmanesh R
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
AD  - Medical Education Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
AD  - Department of Physiology, Faculty of Medicine, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Hamidian, Gholam Reza
AU  - Hamidian GR
AD  - Department of Basic Sciences, Faculty of Veterinary Medicine, University of 
      Tabriz, Tabriz, Iran.
FAU - Ghaderpour, Saber
AU  - Ghaderpour S
AD  - Department of Physiology, Faculty of Medicine, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Ghiasi, Rafighe
AU  - Ghiasi R
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
AD  - Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
AD  - Department of Physiology, Faculty of Medicine, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC8976912
OTO - NOTNLM
OT  - Diabetes
OT  - Hypophysis
OT  - Hypothalamus
OT  - Kisspeptin
OT  - Leptin
OT  - Sperm malformations
OT  - Voluntary exercise
EDAT- 2022/04/19 06:00
MHDA- 2022/04/19 06:01
PMCR- 2021/12/01
CRDT- 2022/04/18 06:35
PHST- 2021/07/03 00:00 [received]
PHST- 2021/11/20 00:00 [accepted]
PHST- 2022/04/18 06:35 [entrez]
PHST- 2022/04/19 06:00 [pubmed]
PHST- 2022/04/19 06:01 [medline]
PHST- 2021/12/01 00:00 [pmc-release]
AID - 10.22038/IJBMS.2021.58740.13048 [doi]
PST - ppublish
SO  - Iran J Basic Med Sci. 2021 Dec;24(12):1624-1631. doi: 
      10.22038/IJBMS.2021.58740.13048.