PMID- 35433259
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220419
IS  - 2213-8803 (Electronic)
IS  - 2213-879X (Print)
IS  - 2213-879X (Linking)
VI  - 10
IP  - 1
DP  - 2022 Jan-Mar
TI  - Diagnosis of Idiopathic Granulomatous Mastitis in a Sudanese Woman.
PG  - 33-35
LID - 10.4103/JMAU.JMAU_51_20 [doi]
AB  - Idiopathic granulomatous mastitis (IGM) is a relatively rare specific chronic 
      inflammatory process of unknown etiology, that diagnostically overlaps with 
      common breast pathologies in Sudan, namely breast cancer (BC) and tuberculous 
      mastitis (TBM). We report the case of a 34-year-old female who presented with a 
      1-month history of a painful lump in the lower outer quadrant of her left breast. 
      A tru-cut biopsy showed features of granulomatous inflammation suggestive of IGM. 
      Four months later, she presented with similar features and fine-needle aspiration 
      cytology (FNAC) confirmed the presence of IGM and excluded the presence of both, 
      BC and TBM. Histology once again confirmed the diagnosis of granulomatous 
      mastitis with no evidence of breast cancer. Grocott's Methenamine Silver, 
      Ziehl-Neelsen stain, and polymerase chain reaction were negative and accordingly 
      the possibility of fungal infection and TBM were excluded. To our knowledge, this 
      is the first case report of IGM in Sudan. FNAC helped in correct diagnosis of our 
      case and importantly, conditions such as BC and TBM were both excluded as common 
      mimickers of IGM. Although breast biopsy is the main golden approach in the 
      diagnosis of IGM in addition to the usefulness of adjunct ancillary 
      microbiological techniques, still further research is needed to establish whether 
      FNAC can be a reliable tool in the diagnosis of IGM with the common practice of 
      this diagnostic tool in Sudan.
CI  - Copyright: (c) 2021 Journal of Microscopy and Ultrastructure.
FAU - Almobarak, Ahmed O
AU  - Almobarak AO
AD  - Department of Pathology, Faculty of Medicine, University of Medical Sciences and 
      Technology, Khartoum, Sudan.
AD  - Research and Training Centre, Alsharg Ahlia College, Kassala, Sudan.
FAU - Siddig, Samar B
AU  - Siddig SB
AD  - Research and Training Centre, Alsharg Ahlia College, Kassala, Sudan.
FAU - Hassan, Ahmed
AU  - Hassan A
AD  - National Public Health Laboratory, Federal Ministry of Health, Khartoum, Sudan.
FAU - Ahmed, Mohamed H
AU  - Ahmed MH
AD  - Department of Medicine and HIV Metabolic Clinic, Milton Keynes University 
      Hospital, NHS Foundation Trust, Eaglestone, Milton Keynes, UK.
LA  - eng
PT  - Case Reports
DEP - 20211202
PL  - India
TA  - J Microsc Ultrastruct
JT  - Journal of microscopy and ultrastructure
JID - 101709862
PMC - PMC9012406
OTO - NOTNLM
OT  - Breast cancer
OT  - idiopathic granulomatous mastitis
OT  - tuberculous mastitis
COIS- There are no conflicts of interest.
EDAT- 2022/04/19 06:00
MHDA- 2022/04/19 06:01
PMCR- 2021/12/02
CRDT- 2022/04/18 06:37
PHST- 2020/06/14 00:00 [received]
PHST- 2020/10/03 00:00 [revised]
PHST- 2020/11/29 00:00 [accepted]
PHST- 2022/04/18 06:37 [entrez]
PHST- 2022/04/19 06:00 [pubmed]
PHST- 2022/04/19 06:01 [medline]
PHST- 2021/12/02 00:00 [pmc-release]
AID - JMAU-10-33 [pii]
AID - 10.4103/JMAU.JMAU_51_20 [doi]
PST - epublish
SO  - J Microsc Ultrastruct. 2021 Dec 2;10(1):33-35. doi: 10.4103/JMAU.JMAU_51_20. 
      eCollection 2022 Jan-Mar.