PMID- 35433578 OWN - NLM STAT- MEDLINE DCOM- 20220419 LR - 20220720 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 10 DP - 2022 TI - Association of Metals and Metalloids With Urinary Albumin/Creatinine Ratio: Evidence From a Cross-Sectional Study Among Elderly in Beijing. PG - 832079 LID - 10.3389/fpubh.2022.832079 [doi] LID - 832079 AB - BACKGROUND: Environmental exposure to toxic elements contributes to the pathogenesis of chronic kidney disease (CKD). Few studies focus on the association of urinary metals and metalloids concentrations with the urinary albumin/creatinine ratio (UACR) among elderly, especially in areas and seasons with severe air pollution. OBJECTIVE: We aimed to evaluate the associations of urinary metals and metalloids concentration with UACR, which is an early and sensitive indicator of CKD. METHOD: We conducted a cross-sectional study among 275 elderly people in Beijing from November to December 2016, which has experienced the most severe air pollution in China. We measured 15 urinary metals and metalloids concentration and estimated their association with UACR using a generalized linear model (GLM). Bayesian kernel machine regression (BKMR) and quantile g-computation (qgcomp) models were also conducted to evaluate the combined effect of metal and metalloid mixtures concentration. RESULTS: Of the 275 elderly people included in the analysis, we found that higher urinary Cu concentration was positively associated with UACR using GLM (beta = 0.36, 95% CI: 0.25, 0.46). Using the BKMR model, we found that the change in UACR was positively associated with a change in urinary Cu concentration from its 25th to 75th percentile value with all other metals and metalloids concentration fixed at their 25th, 50th, or 75th percentile levels. Urinary Cu concentration had the most significant positive contribution (59.15%) in the qgcomp model. Our finding was largely robust in three mixture modeling approaches: GLM, qgcomp, and BKMR. CONCLUSION: This finding suggests that urinary Cu concentration was strongly positively associated with UACR. Further analyses in cohort studies are required to corroborate this finding. CI - Copyright (c) 2022 Li, Zhao, Liu, Mei, Zhou, Zhao, Xu, Ge and Xu. FAU - Li, Ang AU - Li A AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China. AD - Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Zhao, Jiaxin AU - Zhao J AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China. AD - Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Liu, Liu AU - Liu L AD - Chaoyang District Center for Disease Control and Prevention, Beijing, China. FAU - Mei, Yayuan AU - Mei Y AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China. AD - Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Zhou, Quan AU - Zhou Q AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China. AD - Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Zhao, Meiduo AU - Zhao M AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China. AD - Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Xu, Jing AU - Xu J AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China. AD - Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Ge, Xiaoyu AU - Ge X AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China. AD - Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. FAU - Xu, Qun AU - Xu Q AD - Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China. AD - Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220331 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 0 (Albumins) RN - 0 (Metalloids) RN - AYI8EX34EU (Creatinine) SB - IM MH - Aged MH - Albumins MH - Bayes Theorem MH - Beijing MH - Creatinine MH - Cross-Sectional Studies MH - Female MH - Humans MH - Male MH - *Metalloids MH - *Renal Insufficiency, Chronic PMC - PMC9008350 OTO - NOTNLM OT - BKMR OT - UACR OT - elderly OT - kidney function OT - quantile g-computation OT - urinary Cu COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/04/19 06:00 MHDA- 2022/04/20 06:00 PMCR- 2022/03/31 CRDT- 2022/04/18 06:38 PHST- 2021/12/09 00:00 [received] PHST- 2022/03/07 00:00 [accepted] PHST- 2022/04/18 06:38 [entrez] PHST- 2022/04/19 06:00 [pubmed] PHST- 2022/04/20 06:00 [medline] PHST- 2022/03/31 00:00 [pmc-release] AID - 10.3389/fpubh.2022.832079 [doi] PST - epublish SO - Front Public Health. 2022 Mar 31;10:832079. doi: 10.3389/fpubh.2022.832079. eCollection 2022.