PMID- 35433864
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220419
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Co-existing Hypertension and Hyperhomocysteinemia Increases the Risk of Carotid 
      Vulnerable Plaque and Subsequent Vascular Event: An MR Vessel Wall Imaging Study.
PG  - 858066
LID - 10.3389/fcvm.2022.858066 [doi]
LID - 858066
AB  - PURPOSE: This study sought to determine the associations of co-existing 
      hypertension and hyperhomocysteinemia (H-Hcy) with carotid vulnerable plaque 
      features and subsequent vascular events. METHODS: Symptomatic patients with 
      carotid atherosclerosis were enrolled and underwent carotid magnetic resonance 
      (MR) vessel wall imaging. The patients were divided into the following groups: 
      co-existing hypertension and H-Hcy group; isolated hypertension group; isolated 
      H-Hcy group; and control group. The morphological and compositional 
      characteristics of carotid plaques were assessed on MR images and compared among 
      different groups. Univariate and multivariate cox regressions were used to 
      calculate the hazard ratio (HR) and corresponding 95% confidence interval (CI) of 
      co-existing hypertension and H-Hcy in predicting subsequent vascular events after 
      at least 1-year followed-up. RESULTS: In total, 217 patients (mean age, 59.4 +/- 
      11.9 years; 154 males) were recruited. Patients in co-existing hypertension and 
      H-Hcy group had a significantly higher prevalence of carotid lipid-rich necrotic 
      core (LRNC) than isolated H-Hcy and control group (73.2 vs. 43.3 vs. 50%, p = 
      0.015). During the median follow-up time of 12.2 +/- 4.3 months, 61 (39.8%) 
      patients experienced vascular events. After adjusting for baseline confounding 
      factors, co-existing hypertension and H-Hcy (HR, 1.82; 95% CI, 1.01-3.27; p = 
      0.044), presence of carotid LRNC (HR, 2.25; 95% CI, 1.09-4.65; p = 0.029), and 
      combination of co-existing hypertension and H-Hcy and carotid LRNC (HR, 2.39; 95% 
      CI, 1.26-4.43; p = 0.007) were significantly associated with subsequent vascular 
      events. CONCLUSIONS: Co-existing hypertension and H-Hcy are associated with 
      carotid vulnerable plaque features, such as LRNC. Combining co-existing 
      hypertension and H-Hcy with carotid vulnerable plaque features has a stronger 
      predictive value for subsequent vascular events than each measurement alone.
CI  - Copyright (c) 2022 Li, Qiao, Yang, Li, Dai, Chen, Shen and Zhao.
FAU - Li, Dongye
AU  - Li D
AD  - Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      Guangzhou, China.
FAU - Qiao, Huiyu
AU  - Qiao H
AD  - Department of Biomedical Engineering, Center for Biomedical Imaging Research, 
      Tsinghua University School of Medicine, Beijing, China.
FAU - Yang, Xieqing
AU  - Yang X
AD  - Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      Guangzhou, China.
FAU - Li, Jin
AU  - Li J
AD  - Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, 
      Beijing, China.
FAU - Dai, Wei
AU  - Dai W
AD  - Department of Neurology, Chinese People's Liberation Army (PLA) General Hospital, 
      Beijing, China.
FAU - Chen, Xiaoyi
AU  - Chen X
AD  - Department of Radiology, Beijing Geriatric Hospital, Beijing, China.
FAU - Shen, Jun
AU  - Shen J
AD  - Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 
      Guangzhou, China.
FAU - Zhao, Xihai
AU  - Zhao X
AD  - Department of Biomedical Engineering, Center for Biomedical Imaging Research, 
      Tsinghua University School of Medicine, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20220330
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9005821
OTO - NOTNLM
OT  - atherosclerosis
OT  - homocysteine
OT  - hypertension
OT  - stroke
OT  - vulnerable plaque
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. The handling editor YZ declared a shared affiliation with 
      several of the authors DL, XY, and JS at the time of review.
EDAT- 2022/04/19 06:00
MHDA- 2022/04/19 06:01
PMCR- 2022/01/01
CRDT- 2022/04/18 06:39
PHST- 2022/01/20 00:00 [received]
PHST- 2022/03/07 00:00 [accepted]
PHST- 2022/04/18 06:39 [entrez]
PHST- 2022/04/19 06:00 [pubmed]
PHST- 2022/04/19 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.858066 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Mar 30;9:858066. doi: 10.3389/fcvm.2022.858066. 
      eCollection 2022.