PMID- 35435376
OWN - NLM
STAT- MEDLINE
DCOM- 20220419
LR  - 20220531
IS  - 0974-5130 (Electronic)
IS  - 0377-4929 (Linking)
VI  - 65
IP  - 2
DP  - 2022 Apr-Jun
TI  - Neuroblastoma: Application of International Neuroblastoma Pathology 
      Classification on fine needle aspiration cytology smears.
PG  - 387-391
LID - 10.4103/IJPM.IJPM_767_20 [doi]
AB  - BACKGROUND: Neuroblastoma (NB) is the fourth most common tumor of childhood. 
      There is a paucity of literature on its subtyping of cytology and prognostic 
      utility. AIMS: We aimed to study the cytopathological features of NB on the 
      aspirated material, subtype it, and assess the role of International 
      Neuroblastoma Pathology Classification (INPC) classification on cytology smears 
      in the preoperative prognosis of NB. MATERIALS AND METHODS: Fifteen cases of NB 
      reported on fine-needle aspiration cytology (FNAC) in the past 3 years were 
      included. Detailed clinical, radiological, and cytological features were noted. 
      Smears were assessed for characteristics such as cellularity, neuroblasts 
      (cytoplasmic, nuclear details), rosettes, neuropil, Schwann cells, fibroblasts, 
      calcification, and necrosis. Afterward, cases were categorized as 
      undifferentiated (UD), poorly differentiated (PD), and differentiating (D) 
      subtypes. Mitotic-karyorrhectic index (MKI) was calculated and correlated with 
      histopathology. Follow-up was done to date. RESULTS: The age ranged from 19 days 
      to 10 years with an M: F ratio of 3:1. Twelve cases were retroperitoneal, two 
      cervical, and one mediastinal. Metastatic disease was seen in six cases, one to 
      the cervical, four to the bone marrow, and two to the scalp. The International 
      Neuroblastoma Risk Group (INRG) staging system was available in all cases, out of 
      which three were in stage L1, six in stage L2, four in stage M, and two in stage 
      Ms. On cytology, four cases were differentiating NB, five PD NB, and six UD NB. 
      The MKI was high (>4%) in 80% of UD, intermediate (2-4%) in 100% of PD, and low 
      (<2%) in 75% of D cases. MKI corroborated in both histology and cytology, except 
      in one case. CONCLUSION: NB can be subtyped on cytology on the basis of 
      characteristics of neuroblasts, presence of neutrophils, rosettes, and necrosis. 
      UD NB has a high MKI and is associated with a poor prognosis. A preoperative 
      comprehensive reporting of NB on cytology can be very useful in guiding 
      appropriate chemotherapy with some increment in survival. However, larger studies 
      are needed to validate the calculation of MKI on FNA smears.
FAU - Rastogi, Kanika
AU  - Rastogi K
AD  - Department of Pathology, Chacha Nehru Bal Chikitsalaya, Delhi, India.
FAU - Mahajan, Nidhi
AU  - Mahajan N
AD  - Department of Pathology, Chacha Nehru Bal Chikitsalaya, Delhi, India.
FAU - Khatri, Arti
AU  - Khatri A
AD  - Department of Pathology, Chacha Nehru Bal Chikitsalaya, Delhi, India.
FAU - Khan, Niyaz A
AU  - Khan NA
AD  - Department of Pediatric Surgery, Chacha Nehru Bal Chikitsalaya, Delhi, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Pathol Microbiol
JT  - Indian journal of pathology & microbiology
JID - 7605904
SB  - IM
MH  - Biopsy, Fine-Needle
MH  - Child
MH  - Child, Preschool
MH  - Cytodiagnosis
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Necrosis
MH  - *Neuroblastoma/diagnosis
MH  - Prognosis
OTO - NOTNLM
OT  - Cytology
OT  - MKI
OT  - neuroblastic tumors
OT  - prognosis
OT  - round cell tumor
COIS- None
EDAT- 2022/04/19 06:00
MHDA- 2022/04/20 06:00
CRDT- 2022/04/18 08:42
PHST- 2022/04/18 08:42 [entrez]
PHST- 2022/04/19 06:00 [pubmed]
PHST- 2022/04/20 06:00 [medline]
AID - IndianJPatholMicrobiol_2022_65_2_387_343203 [pii]
AID - 10.4103/IJPM.IJPM_767_20 [doi]
PST - ppublish
SO  - Indian J Pathol Microbiol. 2022 Apr-Jun;65(2):387-391. doi: 
      10.4103/IJPM.IJPM_767_20.